GABA release in the dorsal raphe nucleus: role in the control of REM sleep.

TitleGABA release in the dorsal raphe nucleus: role in the control of REM sleep.
Publication TypeJournal Article
Year of Publication1997
AuthorsNitz D, Siegel J
JournalAm J Physiol
Issue1 Pt 2
Date Published1997 Jul
KeywordsAnalysis of Variance, Animals, Brain Mapping, Cats, gamma-Aminobutyric Acid, Glutamic Acid, Glycine, Homeostasis, Microdialysis, Microinjections, Muscimol, Perfusion, Picrotoxin, Raphe Nuclei, Sleep, Sleep, REM, Time Factors, Wakefulness

The cessation of firing of serotonergic dorsal raphe neurons is a key controlling event of rapid eye movement (REM) sleep. We tested the hypothesis that this cessation of activity is due to gamma-aminobutyric acid (GABA) release using the in vivo microdialysis technique. We found that REM sleep is accompanied by a selective increase in GABA release, but not by a change in glutamate or glycine release in the dorsal raphe nucleus. Microinjection of the GABA agonist muscimol into the dorsal raphe increased REM sleep, although microperfusion of the GABA antagonist picrotoxin blocked REM sleep. These results implicate GABA release as a critical element in the production of the REM sleep state and in the control of discharge in serotonergic neurons across the sleep/wake cycle.

Alternate JournalAm J Physiol
PubMed ID9249585
Grant ListHL-41370 / HL / NHLBI NIH HHS / United States
NS-14610 / NS / NINDS NIH HHS / United States
NS-23724 / NS / NINDS NIH HHS / United States