A brief history of hypocretin/orexin and narcolepsy.

TitleA brief history of hypocretin/orexin and narcolepsy.
Publication TypeJournal Article
Year of Publication2001
AuthorsSiegel JM, Moore R, Thannickal T, Nienhuis R
JournalNeuropsychopharmacology
Volume25
Issue5 Suppl
PaginationS14-20
Date Published2001 Nov
ISSN0893-133X
KeywordsAnimals, Carrier Proteins, History, 20th Century, Humans, Intracellular Signaling Peptides and Proteins, Narcolepsy, Neuropeptides, Orexins
Abstract

The hypothalamic peptides named the orexins, or hypocretins, were discovered in 1998. In 1999 it was established that genetic narcolepsy could be caused by mutations in the genes synthesizing these peptides or their receptors. In September of 2000 it was found that most human narcolepsy is caused by loss of hypocretin cells, most likely as a result of a degenerative process. This paper reviews these events and their implications for our understanding of brain arousal and motor control systems.

DOI10.1016/S0893-133X(01)00317-7
Alternate JournalNeuropsychopharmacology
PubMed ID11682268
PubMed Central IDPMC8788648
Grant ListHL60296 / HL / NHLBI NIH HHS / United States
R01 NS014610 / NS / NINDS NIH HHS / United States
NS14610 / NS / NINDS NIH HHS / United States
P50 HL060296 / HL / NHLBI NIH HHS / United States
R01 MH064109 / MH / NIMH NIH HHS / United States
R37 NS014610 / NS / NINDS NIH HHS / United States
MH64109 / MH / NIMH NIH HHS / United States