A brief history of hypocretin/orexin and narcolepsy.
| Title | A brief history of hypocretin/orexin and narcolepsy. |
| Publication Type | Journal Article |
| Year of Publication | 2001 |
| Authors | Siegel JM, Moore R, Thannickal T, Nienhuis R |
| Journal | Neuropsychopharmacology |
| Volume | 25 |
| Issue | 5 Suppl |
| Pagination | S14-20 |
| Date Published | 2001 Nov |
| ISSN | 0893-133X |
| Keywords | Animals, Carrier Proteins, History, 20th Century, Humans, Intracellular Signaling Peptides and Proteins, Narcolepsy, Neuropeptides, Orexins |
| Abstract | The hypothalamic peptides named the orexins, or hypocretins, were discovered in 1998. In 1999 it was established that genetic narcolepsy could be caused by mutations in the genes synthesizing these peptides or their receptors. In September of 2000 it was found that most human narcolepsy is caused by loss of hypocretin cells, most likely as a result of a degenerative process. This paper reviews these events and their implications for our understanding of brain arousal and motor control systems. |
| DOI | 10.1016/S0893-133X(01)00317-7 |
| Alternate Journal | Neuropsychopharmacology |
| PubMed ID | 11682268 |
| PubMed Central ID | PMC8788648 |
| Grant List | HL60296 / HL / NHLBI NIH HHS / United States R01 NS014610 / NS / NINDS NIH HHS / United States NS14610 / NS / NINDS NIH HHS / United States P50 HL060296 / HL / NHLBI NIH HHS / United States R01 MH064109 / MH / NIMH NIH HHS / United States R37 NS014610 / NS / NINDS NIH HHS / United States MH64109 / MH / NIMH NIH HHS / United States |
