"Effects of sodium oxybate on hypocretin/orexin and locus coeruleus neurons"
"Opiate anticipation,opiate induced anatomical changes in hypocretin (Hcrt, orexin) neurons and opiate induced microglial activation are blocked by the dual Hcrt receptor antagonist suvorexant, while opiate analgesia is maintained."
"Sensitivity of hypocretin system to chronic alcohol exposure: a human and animal study"
"Hypocretin/orexin interactions with norepinephrine contribute to the opiate withdrawal syndrome."
J Neurosci 2022
"Nuclear organization of orexinergic neurons in the hypothalamus of a lar gibbon and a chimpanzee"
The Anatomical Record 2021
"Pleasure, addiction and hypocretin (orexin)"
Handbook of Clinical Neurology, The Human Hypothalamus: Middle And Posterior Region 2021
"Opiates increase the number of hypocretin-producing cells in human and mouse brain and reverse cataplexy in a mouse model of narcolepsy."
Science Translational Medicine 2018
"Striking cessation of cataplexy by opioids."
J Sleep Res 2018
"Diurnal fluctuation in the number of hypocretin/orexin and histamine producing: Implication for understanding and treating neuronal loss"
PLOS ONE 2017
"Interactions of the histamine and hypocretin systems in CNS disorders."
Nature Reviews Neurology 2015
"Cataplexy--clinical aspects, pathophysiology and management strategy."
Nature Reviews Neurology 2014
"Gender differences between hypocretin/orexin knockout and wild type mice: age, body weight, body composition, metabolic markers, leptin and insulin resistance."
J Neurochem 2014
"Greatly increased numbers of histamine cells in human narcolepsy with cataplexy."
Annals of Neurology 2013
"Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction."
Nature Communications 2013
"Coexistence of narcolepsy and Alzheimer's disease."
Neurobiol Aging 2012
"Highly specific role of hypocretin (orexin) neurons: differential activation as a function of diurnal phase, operant reinforcement versus operant avoidance and light level."
J Neurosci 2011
"Role of the hypocretin (orexin) receptor 2 (Hcrt-r2) in the regulation of hypocretin level and cataplexy."
J Neurosci 2011
"A consensus definition of cataplexy in mouse models of narcolepsy."
"Localized loss of hypocretin (orexin) cells in narcolepsy without cataplexy."
"Hypocretin (orexin) cell loss in Parkinson's disease."
"Systemic and nasal delivery of orexin-A (Hypocretin-1) reduces the effects of sleep deprivation on cognitive performance in nonhuman primates."
J Neurosci 2007
"Narcolepsy and the hypocretin system--where motion meets emotion."
Nature Clinical Practice Neurology [Nature Reviews Neurology] 2006
"Behavioral correlates of activity in identified hypocretin/orexin neurons."
"Narp immunostaining of human hypocretin (orexin) neurons: loss in narcolepsy."
"Hypocretin (orexin): role in normal behavior and neuropathology."
Annual Reviews of Psychology 2004
"Pattern of hypocretin (orexin) soma and axon loss, and gliosis, in human narcolepsy."
Brain Pathology 2003
"A brief history of hypocretin/orexin and narcolepsy."
Scientific American 2000
"Recent developments in narcolepsy research, an explanation for patients and the general public"
Narcolepsy Network Newsletter 2000
"Systemic administration of hypocretin-1 reduces cataplexy and normalizes sleep and waking durations in narcoleptic dogs."
Sleep Res Online 2000
"Locus coeruleus neurons: cessation of activity during cataplexy."
"Neuronal degeneration in canine narcolepsy."
J Neurosci 1999
"Neuronal activity in narcolepsy: identification of cataplexy-related cells in the medial medulla."
"Heart rate and blood pressure changes associated with cataplexy in canine narcolepsy."