Our goal is to better understand the evolution, function and disorders of sleep.

A major focus of the laboratory is on the peptide hypocretin (orexin), whose loss is responsible for narcolepsy. Hypocretin has a major role in opiate and cocaine addiction. Our work on the control of sleep and motor activity has relevance to an understanding of sleep apnea, REM sleep behavior disorder, restless legs syndrome and nocturnal bruxism. 

Director: Jerome Siegel My Bibliography  https://www.ncbi.nlm.nih.gov/myncbi/jerome.siegel.1/bibliography/public/