"Opiates increase the number of hypocretin-producing cells in human and mouse brain and reverse cataplexy in a mouse model of narcolepsy."
Science Translational Medicine 2018
"Striking cessation of cataplexy by opioids."
J Sleep Res 2018
"Interactions of the histamine and hypocretin systems in CNS disorders."
Nature Reviews Neurology 2015
"Cataplexy--clinical aspects, pathophysiology and management strategy."
Nature Reviews Neurology 2014
"Gender differences between hypocretin/orexin knockout and wild type mice: age, body weight, body composition, metabolic markers, leptin and insulin resistance."
J Neurochem 2014
"Greatly increased numbers of histamine cells in human narcolepsy with cataplexy."
Annals of Neurology 2013
"Coexistence of narcolepsy and Alzheimer's disease."
Neurobiol Aging 2012
"Highly specific role of hypocretin (orexin) neurons: differential activation as a function of diurnal phase, operant reinforcement versus operant avoidance and light level."
J Neurosci 2011
"Role of the hypocretin (orexin) receptor 2 (Hcrt-r2) in the regulation of hypocretin level and cataplexy."
J Neurosci 2011
"A consensus definition of cataplexy in mouse models of narcolepsy."
"Localized loss of hypocretin (orexin) cells in narcolepsy without cataplexy."
"Hypocretin (orexin) cell loss in Parkinson's disease."
"Systemic and nasal delivery of orexin-A (Hypocretin-1) reduces the effects of sleep deprivation on cognitive performance in nonhuman primates."
J Neurosci 2007
"Narcolepsy and the hypocretin system--where motion meets emotion."
Nature Clinical Practice Neurology [Nature Reviews Neurology] 2006
"Narp immunostaining of human hypocretin (orexin) neurons: loss in narcolepsy."
"Pattern of hypocretin (orexin) soma and axon loss, and gliosis, in human narcolepsy."
Brain Pathology 2003
"Human narcolepsy is linked to reduced number, size and synaptic bouton density In hypocretin-2 labeled neurons."
Society for Neuroscience 2000
Scientific American 2000
"Recent developments in narcolepsy research, an explanation for patients and the general public"
Narcolepsy Network Newsletter 2000
"Reduced number of hypocretin neurons in human narcolepsy."