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Research Program

Program for ADHD and Related Conditions (PARC)

Leadership

James McGough, MD
UCLA ADHD Clinic Co-Director

Sandra Loo, PhD
Director of Pediatric Neuropsychology

Contact Info

Program for ADHD and Related Conditions Website

760 Westwood Plaza
Los Angeles, CA
adhdandmood@ucla.edu
(310) 825-3735

About

As members of the Program for ADHD and Related Conditions (PARC), we seek to develop a better understanding of childhood emotional and behavioral disorders, as well as to develop new treatment approaches.  By studying the interaction between physiological and psychological processes in children and adolescents, we hope to learn more about how specific brain functions can cause specific behaviors. This may ultimately lead us to design and evaluate more effective treatments and provide better diagnosis.

Currently 1 in 10 children have been diagnosed with ADHD (CDC, 2015).  There are many established treatments for ADHD, and all were developed through the process of clinical research.  Clinical research helps to advance our understanding of ADHD and novel treatment approaches that may best target symptoms of the disorder. 

As a research team, we have seen many children and adults in our clinical practices at UCLA struggle with ADHD.  Our new research interests involve novel non-medication treatments for children and adults with ADHD to reduce ADHD symptoms and impairment and improve cognitive functioning. Currently, we are recruiting children with ADHD at two study sites: LA (UCLA) and Seattle (Seattle Children’s Hospital).


Common Parent Questions

What is ADHD?
  • Symptoms include difficulty staying focused and paying attention, difficulty controlling behavior, and hyperactivity (over-activity).
  • There are three subtypes, defined by the number of different types of symptoms present:
    • Predominantly hyperactive-impulsive
    • Predominantly inattentive
    • Combined hyperactive-impulsive and inattentive
What are treatment options for ADHD?

There are several treatment options available for individuals diagnosed with ADHD depending on areas of impairment. If you need help sustaining attention or managing hyperactivity, pharmacotherapy (medication) may be appropriate. Non-medication alternative for children and adults with ADHD are currently being explored at UCLA. If you struggle with using your executive functions such as planning, getting started on tasks, organizing your space, breaking tasks down, etc, then executive function intervention is an option. To help children manage their behaviors, we also frequently recommend parent training

If you would like to hear more about the treatment options available at UCLA, please call (310)267-4798 or email adhdandmood@ucla.edu

    What about irritability and mood?

    Irritability is defined as a feeling of agitation and excessive response to stimuli. Irritability is a symptom that presents itself in many different disorders, including Anxiety, Oppositional Defiant Disorder, Depression, and Severe Mood Dysregulation.

    Irritability has received much attention in recent years from academia and public media (LA Times). Practicing clinicians frequently discuss the difficulty in treating children who experience significant irritability and parents report struggling with their child’s difficult behavior and the effect on family well-being. 

    Chronic irritability often affects children with anxiety, depression, ODD, and severe mood dysregulation. Irritability is a symptom of approximately 61% of children with depression, and is associated with greater risk of concurrent disruptive behaviors (including oppositional defiant disorder and conduct disorder) (Stringaris et al., 2013).  Moreover, approximately 50% of adults with major depressive disorder experience significant irritability that is associated with greater depressive severity, longer major depressive episodes, and poorer impulse control among other negative long-term outcomes (Judd et al., 2013). The consequences of severe irritability are also not limited to depression. Irritability in oppositional defiant disorder in childhood is also associated with more negative long-term outcomes.

    As a clinical research group, we aim to explore treatment options for children with irritability and comorbid conditions. Currently, we are conducting a clinical trial to treat severe mood dysregulation in children and adolescents. 

    What is Oppositional Defiant Disorder (ODD)?

    ODD is characterized by an ongoing pattern of anger-guided disobedience, and excessively defiant and hostile behavior towards authority that persists for at least 6 months. There is a frequent occurrence of 4 of the following behaviors: losing temper, arguing with adults, actively defying or refusing to comply with the requests or rules of adults, deliberately doing things to annoy other people, blaming others for his or her own mistakes, being touchy or easily annoyed by others, being angry or resentful, or being spiteful or vindictive.

    To meet diagnosis criteria, the behaviors must occur more frequently than is typically observed in individuals of comparable developmental level, and lead to significant impairment in social, academic, or occupational functioning.

    ODD and ADHD often co-occur. 

    Treatment Options for ODD

    We recommend parent training for parents of children with ODD. Implementing limit setting, AM and PM routines, and effective commands are essential for behavior modification and can be learned through participation in the UCLA Parenting Program

     

    What is Conduct Disorder?

    Conduct Disorder refers to a group of behavioral and emotional problems in children and adolescents. Individuals with a conduct disorder have excessive difficulty following rules and behaving in a socially acceptable way. They tend to be impulsive, hard to control, and not concerned about the feelings of other people. Individuals with a conduct disorder have a repetitive and persistent pattern of behaviors that fall into four major groupings, including: aggression to people and animals, destruction of property, deceitfulness or theft, and serious violation of rules.  

    It is common for children with a conduct disorder to have coexisting conditions such as mood disorders, anxiety, PTSD, substance abuse, ADHD, or learning problems.

    Treatment Options for Conduct Disorder

    We recommend parent training and problem-solving skills training for children diagnosed with conduct disorder. Implementing limit setting, AM and PM routines, and effective commands are essential for behavior modification and can be learned through participation in the UCLA Parenting Program. UCLA does not currently offer a specific problem-solving skills training program for children, but many therapists use these techniques in their practices. 

     


    To participate in the non-medication study, please scan the QR code or complete the survey linked here.

    We hope to better serve individuals and families through research opportunities that target a child’s emotional and behavioral needs. If you are interested in participating in research regarding ADHD and Related Conditions, contact us! You can also learn more about our interdisciplinary team below..  


    Team

    • James McGough, M.D.

      Professor of Clinical Psychiatry, UCLA ADHD Clinic Co-Director
    • Sandra Loo, Ph.D.

      Professor of Psychiatry, Director of Pediatric Neuropsychology
    • Jenny Cowen, Ph.D.

      Administrative Director of Clinical Research
    • Ani Dillon, Psy.D.

      Clinical Research Neuropsychologist
    • Kelsey Stiles, Ph.D

      Postdoctoral Fellow
    • Maya Tooker

      Research Associate
    • Sarah Fulton

      Research Associate
    • Anjika Friedman-Jha

      Research Associate
    • Christine Eun

      Undergraduate Research Assistant

    ADHD Clinic

    Dr. Jim McGough and Dr. Melissa Del’Homme are the co-directors of the UCLA ADHD clinic

    The ADHD Clinic offers state-of-the-art services for children, adolescents, and adults with attention-seficit/hyperactivity disorder (ADD/ ADHD). The ADHD Clinic is comprised of an interdisciplinary team specializing in the evaluation, treatment, and support of individuals with attention deficits, learning problems, and related behavioral difficulties.

    Services

    For scheduling, pricing, and prescription related inquiries, call UCLA ACCESS at (310) 825-9989

    Note: ACCESS schedules for several clinics at UCLA, so be sure to mention the ADHD clinic during your phone call. 


    Treatment Studies

    Innovative Non-Medication Treatment Study for ADHD
    STATUSACTIVE AND SEEKING PARTICIPANTS
    AGE7 – 12 years of age
    ELIGIBILITYDiagnosed with ADHD or has symptoms of inattention, hyperactivity, or impulsivity
    STUDY LENGTH4 – 8 weeks, possible extension
    STUDY DETAILSParticipants will receive a comprehensive ADHD evaluation, EEGs, weekly questionnaires, and a novel medical treatmentFor this innovative treatment, mild electrical signals are used to stimulate the brain during sleep in order to improve behaviors associated with ADHD
    FLYERFor more information, please view our study flyer here.
    PUBLICATIONSThe details and results of our previous TNS research studies can be found here:An Eight-week, Open-trial, Pilot Feasibility Study of Trigeminal Nerve Stimulation in Youth With Attention-deficit/Hyperactivity DisorderDouble-Blind, Sham-Controlled, Pilot Study of Trigeminal Nerve Stimulation for Attention-Deficit/Hyperactivity Disorder
    PRINCIPAL INVESTIGATOR: Dr. James McGough
    Flash Light Therapy and CBT for ADHD Study
    STATUSACTIVE AND SEEKING PARTICIPANTS
    AGE14 – 17 years of age
    ELIGIBILITYDiagnosed with ADHDDelayed Sleep-Wake Schedule
    STUDY LENGTH7 weeks 
    STUDY DETAILSParticipants will receive 2 weeks of flashed light therapy and 4 weeks of cognitive behavioral therapy and at-home flashed light therapy 7 weeks of continuous sleep monitoring with watch and sleep diary
    FLYERFor more information, please view our study flyer here.
    PRINCIPAL INVESTIGATOR: Dr. Emily Ricketts
    Parents of Preschoolers Study
    Skills Group for Teens

    Research studies help us to advance our knowledge of ADHD and other behavioral disorders. Participating in clinical trials is a great way to access new and cutting-edge treatment. Please contact us at (310) 825-3735 or adhdandmood@ucla.edu if you are interested or know someone who may be interested in participating. All treatment is provided at no cost.