Brain Imaging Biomarkers as Response to A Novel Lower Extremity Motor Intersection in Children with Cerebral Palsy

Project Summary

In progress.

Corticosteroids are the only pharmacological interventions currently available that increase muscle strength in DMD. The use of corticosteriods was first suggested in 1974. Both prednisone/prednisolone and deflazacort have been shown to increase muscle strength. This study is an international, multi-center, randomized, double-blind controlled trial comparing three active corticosteriod regimens over three years of treatment. It is anticipated that it will take two years to enroll the 300 subjects. The primary outcome variable will be a three-dimensional outcome comprising muscle function, respiratory function and treatment.

Timescale: 07/01/2015 - 06/30/2021
Current status: Project live


Primary Investigator: Eileen Fowler