Bone density in premenopausal women and men under 50 years of age with cerebral palsy.
|Title||Bone density in premenopausal women and men under 50 years of age with cerebral palsy.|
|Publication Type||Journal Article|
|Year of Publication||2015|
|Authors||Fowler EG, Rao S, Nattiv A, Heberer K, Oppenheim WL|
|Journal||Arch Phys Med Rehabil|
|Date Published||2015 Jul|
|Keywords||Absorptiometry, Photon, Adult, Body Mass Index, Bone Density, Cerebral Palsy, Cross-Sectional Studies, Female, Femur Neck, Hip Joint, Humans, Lumbar Vertebrae, Male, Middle Aged, Premenopause, Reference Values, Risk Factors, Severity of Illness Index|
OBJECTIVE: To determine bone mineral density (BMD) z scores in adults with cerebral palsy (CP), an understudied population.
SETTING: Medical facility.
PARTICIPANTS: Adults (N=48; mean age, 34.3±5.8y; range, 25-46y) with CP.
INTERVENTIONS: Not applicable.
MAIN OUTCOME MEASURES: BMD z scores at the lumbar spine and hip using dual-energy x-ray absorptiometry, Gross Motor Function Classification System (GMFCS), body mass index (BMI), and ambulatory status.
RESULTS: Mean BMD z scores were -1.40 for the lumbar spine, -1.36 for the total hip, and -1.02 for the femoral neck. The z scores were significantly lower for the nonambulatory group at all 3 sites (P<.05). Significant differences were found among GMFCS levels for the lumbar spine and total hip z scores (P<.05). For the lumbar spine, the mean z scores for level V (the lowest mobility level) were significantly lower than the mean for levels I/II (P=.001), III (P=.002), and IV (P=.013). For the total hip, the mean z scores for level V were significantly lower than the mean for levels I/II (P=.045). A significant positive relationship between the z scores and age was found for the lumbar spine (Spearman ρ=.40, P=.005). Significant positive relationships between BMI and z scores were found for all sites (P<.05).
CONCLUSIONS: This study contributes to the sparse literature about bone health in adults with CP. In contrast with pediatric data, z scores did not decrease as a function of age in this adult cohort. This information is important for clinicians considering treatment options for this population.
|Alternate Journal||Arch Phys Med Rehabil|