The neurobiology of sleep.

TitleThe neurobiology of sleep.
Publication TypeJournal Article
Year of Publication2009
AuthorsSiegel JM
JournalSemin Neurol
Date Published2009 Sep
KeywordsAnimals, Brain Stem, Humans, Narcolepsy, Neurobiology, Neurotransmitter Agents, Sleep

The neurobiology of sleep and narcolepsy is reviewed. Non-rapid eye movement (NREM) sleep is generated by neurons in the preoptic region of the hypothalamus and adjacent basal forebrain. Lesions in these regions cause insomnia. Stimulation of these regions rapidly produces sleep onset. The key brain structure for generating REM sleep is the pons and adjacent portions of the midbrain. Damage to the pons and/or caudal midbrain can cause abnormalities in REM sleep. The persistent sleepiness of narcolepsy is a result of a loss of hypocretin function.

Alternate JournalSemin Neurol
PubMed ID19742406