Wendy Walwyn

Titles

Member, Brain Research Institute

Adjunct Professor, Psychiatry and Biobehavioral Sciences

Hatos Center for Neuropharmacology

Contact Information

Email
wwalwyn@g.ucla.edu
Phone
Fax Number: (310) 206-7067
Work Phone Number: (310) 206-3231
Address

Mailing Address:

MRL Building
675 Charles Young Drive
Los Angeles, CA 90095
UNITED STATES

Biography

Publications

A selected list of publications:

Smith Wesley C, Rosenberg Matthew H, Claar Leslie D, Chang Victoria, Shah Sagar N, Walwyn Wendy M, Evans Christopher J, Masmanidis Sotiris C   Frontostriatal Circuit Dynamics Correlate with Cocaine Cue-Evoked Behavioral Arousal during Early Abstinence eNeuro, ; 3(3): .
Storey, G. P.; Gonzalez-Fernandez, G.; Bamford, I. J.; Hur, M.; McKinley, J. W.; Heimbigner, L.; Minasyan, A.; Walwyn, W. M.; Bamford, N. S.   Nicotine Modifies Corticostriatal Plasticity and Amphetamine Rewarding Behaviors in Mice(1,2,3) eNeuro, 2016; 3(1): .
Taylor, A. M.; Roberts, K. W.; Pradhan, A. A.; Akbari, H. A.; Walwyn, W.; Lutfy, K.; Carroll, F. I.; Cahill, C. M.; Evans, C. J.   Anti-nociception mediated by a kappa opioid receptor agonist is blocked by a delta receptor agonist Br J Pharmacol, 2015; 172(2): 691-703.
Marvizon, J. C.; Walwyn, W.; Minasyan, A.; Chen, W.; Taylor, B. K.   Latent sensitization: a model for stress-sensitive chronic pain Curr Protoc Neurosci, 2015; 71: 9 50 1-9 50 14.
Marvizon, J. C.; Walwyn, W.; Minasyan, A.; Chen, W.; Taylor, B. K.   Latent sensitization: a model for stress-sensitive chronic pain Curr Protoc Neurosci, 2015; 71: 9 50 1-9 50 14.
Gendron, L.; Mittal, N.; Beaudry, H.; Walwyn, W.   Recent advances on the delta opioid receptor: from trafficking to function Br J Pharmacol, 2015; 172(2): 403-19.
Chen, W.; Walwyn, W.; Ennes, H. S.; Kim, H.; McRoberts, J. A.; Marvizon, J. C.   BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals Eur J Neurosci, 2014; 39(9): 1439-54.
Cui, Y.; Ostlund, S. B.; James, A. S.; Park, C. S.; Ge, W.; Roberts, K. W.; Mittal, N.; Murphy, N. P.; Cepeda, C.; Kieffer, B. L.; Levine, M. S.; Jentsch, J. D.; Walwyn, W. M.; Sun, Y. E.; Evans, C. J.; Maidment, N. T.; Yang, X. W.   Targeted expression of mu-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward Nat Neurosci, 2014; 17(2): 254-61.
Pradhan, A.; Smith, M.; McGuire, B.; Evans, C.; Walwyn, W.   Chronic inflammatory injury results in increased coupling of delta opioid receptors to voltage-gated Ca2+ channels Mol Pain, 2013; 9: 8.
Weibel, R.; Reiss, D.; Karchewski, L.; Gardon, O.; Matifas, A.; Filliol, D.; Becker, J. A.; Wood, J. N.; Kieffer, B. L.; Gaveriaux-Ruff, C.   Mu opioid receptors on primary afferent nav1.8 neurons contribute to opiate-induced analgesia: insight from conditional knockout mice PLoS One, 2013; 8(9): e74706.
Mittal, N.; Tan, M.; Egbuta, O.; Desai, N.; Crawford, C.; Xie, C. W.; Evans, C.; Walwyn, W.   Evidence that behavioral phenotypes of morphine in beta-arr2-/- mice are due to the unmasking of JNK signaling Neuropsychopharmacology, 2012; 37(8): 1953-62.
Lam, H.; Maga, M.; Pradhan, A.; Evans, C. J.; Maidment, N. T.; Hales, T. G.; Walwyn, W.   Analgesic tone conferred by constitutively active mu opioid receptors in mice lacking beta-arrestin 2 Mol Pain, 2011; 7: 24.
Walwyn, W.; John, S.; Maga, M.; Evans, C. J.; Hales, T. G.   Delta receptors are required for full inhibitory coupling of mu-receptors to voltage-dependent Ca(2+) channels in dorsal root ganglion neurons Mol Pharmacol, 2009; 76(1): 134-43.
Otoshi, C. K.; Walwyn, W. M.; Tillakaratne, N. J.; Zhong, H.; Roy, R. R.; Edgerton, V. R.   Distribution and localization of 5-HT(1A) receptors in the rat lumbar spinal cord after transection and deafferentation J Neurotrauma, 2009; 26(4): 575-84.
Walwyn, W. M.; Matsuka, Y.; Arai, D.; Bloom, D. C.; Lam, H.; Tran, C.; Spigelman, I.; Maidment, N. T.   HSV-1-mediated NGF delivery delays nociceptive deficits in a genetic model of diabetic neuropathy Exp Neurol, 2006; 198(1): 260-70.
Walwyn, W.; Maidment, N. T.; Sanders, M.; Evans, C. J.; Kieffer, B. L.; Hales, T. G.   Induction of delta opioid receptor function by up-regulation of membrane receptors in mouse primary afferent neurons Mol Pharmacol, 2005; 68(6): 1688-98.
Walwyn, W. M.; Keith, D. E., Jr.; Wei, W.; Tan, A. M.; Xie, C. W.; Evans, C. J.; Kieffer, B. L.; Maidment, N. T.   Functional coupling, desensitization and internalization of virally expressed mu opioid receptors in cultured dorsal root ganglion neurons from mu opioid receptor knockout mice Neuroscience, 2004; 123(1): 111-21.
Irnaten, M.; Walwyn, W. M.; Wang, J.; Venkatesan, P.; Evans, C.; Chang, K. S.; Andresen, M. C.; Hales, T. G.; Mendelowitz, D.   Pentobarbital enhances GABAergic neurotransmission to cardiac parasympathetic neurons, which is prevented by expression of GABA(A) epsilon subunit Anesthesiology, 2002; 97(3): 717-24.
Skoubis, P. D.; Matthes, H. W.; Walwyn, W. M.; Kieffer, B. L.; Maidment, N. T.   Naloxone fails to produce conditioned place aversion in mu-opioid receptor knock-out mice Neuroscience, 2001; 106(4): 757-63.
Walwyn, W. M.; Ta-Haung, J.; Ackerson, L.; Maidment, N. T.; Edgerton, V. R.   Extracellular glutamate in the dorsal horn of the lumbar spinal cord in the freely moving rat during hindlimb stepping Pharmacol Biochem Behav, 1999; 63(4): 581-8.
Pradhan Amynah A, Perroy Julie, Walwyn Wendy M, Smith Monique L, Vicente-Sanchez Ana, Segura Laura, Bana Alia, Kieffer Brigitte L, Evans Christopher J   Agonist-Specific Recruitment of Arrestin Isoforms Differentially Modify Delta Opioid Receptor Function The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016; 36(12): 3541-51.
Walwyn, W. M.; Chen, W.; Kim, H.; Minasyan, A.; Ennes, H. S.; McRoberts, J. A.; Marvizon, J. C.   Sustained Suppression of Hyperalgesia during Latent Sensitization by mu-, delta-, and kappa-opioid receptors and alpha2A Adrenergic Receptors: Role of Constitutive Activity J Neurosci, 2016; 36(1): 204-21.
Mittal, N.; Roberts, K.; Pal, K.; Bentolila, L. A.; Fultz, E.; Minasyan, A.; Cahill, C.; Pradhan, A.; Conner, D.; DeFea, K.; Evans, C.; Walwyn, W.   Select G-protein-coupled receptors modulate agonist-induced signaling via a ROCK, LIMK, and beta-arrestin 1 pathway Cell Rep, 2013; 5(4): 1010-21.
James, A. S.; Chen, J. Y.; Cepeda, C.; Mittal, N.; Jentsch, J. D.; Levine, M. S.; Evans, C. J.; Walwyn, W.   Opioid self-administration results in cell-type specific adaptations of striatal medium spiny neurons Behav Brain Res, 2013; 256: 279-83.
Pradhan, A. A.; Walwyn, W.; Nozaki, C.; Filliol, D.; Erbs, E.; Matifas, A.; Evans, C.; Kieffer, B. L.   Ligand-directed trafficking of the delta-opioid receptor in vivo: two paths toward analgesic tolerance J Neurosci, 2010; 30(49): 16459-68.
Walwyn, W. M.; Miotto, K. A.; Evans, C. J.   Opioid pharmaceuticals and addiction: the issues, and research directions seeking solutions Drug Alcohol Depend, 2010; 108(3): 156-65.
Tan, M.; Walwyn, W. M.; Evans, C. J.; Xie, C. W.   p38 MAPK and beta-arrestin 2 mediate functional interactions between endogenous micro-opioid and alpha2A-adrenergic receptors in neurons J Biol Chem, 2009; 284(10): 6270-81.
Walwyn Wendy, Evans Christopher J, Hales Tim G   Beta-arrestin2 and c-Src regulate the constitutive activity and recycling of mu opioid receptors in dorsal root ganglion neurons The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007; 27(19): 5092-104.
Walwyn, W. M. Wei, W. Xie, C. W. Chiu, K. Kieffer, B. L. Evans, C. J. Maidment, N. T.   Mu opioid receptor-effector coupling and trafficking in dorsal root ganglia neurons Neuroscience, 2006; 142(2): 493-503.
Walwyn, W. M.; Wei, W.; Xie, C. W.; Chiu, K.; Kieffer, B. L.; Evans, C. J.; Maidment, N. T.   Mu opioid receptor-effector coupling and trafficking in dorsal root ganglia neurons Neuroscience, 2006; 142(2): 493-503.
Walwyn, W. M. Matsuka, Y. Arai, D. Bloom, D. C. Lam, H. Tran, C. Spigelman, I. Maidment, N. T.   HSV-1-mediated NGF delivery delays nociceptive deficits in a genetic model of diabetic neuropathy Exp Neurol, 2006; 198(1): 260-70.
Walwyn, W. Maidment, N. T. Sanders, M. Evans, C. J. Kieffer, B. L. Hales, T. G.   Induction of delta opioid receptor function by up-regulation of membrane receptors in mouse primary afferent neurons Mol Pharmacol, 2005; 68(6): 1688-98.
Walwyn, W. M. Keith, D. E., Jr. Wei, W. Tan, A. M. Xie, C. W. Evans, C. J. Kieffer, B. L. Maidment, N. T.   Functional coupling, desensitization and internalization of virally expressed mu opioid receptors in cultured dorsal root ganglion neurons from mu opioid receptor knockout mice Neuroscience, 2004; 123(1): 111-21.
Lutfy, K. Eitan, S. Bryant, C. D. Yang, Y. C. Saliminejad, N. Walwyn, W. Kieffer, B. L. Takeshima, H. Carroll, F. I. Maidment, N. T. Evans, C. J.   Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors J Neurosci, 2003; 23(32): 10331-7.
Lutfy, K.; Eitan, S.; Bryant, C. D.; Yang, Y. C.; Saliminejad, N.; Walwyn, W.; Kieffer, B. L.; Takeshima, H.; Carroll, F. I.; Maidment, N. T.; Evans, C. J.   Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors J Neurosci, 2003; 23(32): 10331-7.
Irnaten, M. Walwyn, W. M. Wang, J. Venkatesan, P. Evans, C. Chang, K. S. Andresen, M. C. Hales, T. G. Mendelowitz, D.   Pentobarbital enhances GABAergic neurotransmission to cardiac parasympathetic neurons, which is prevented by expression of GABA(A) epsilon subunit Anesthesiology, 2002; 97(3): 717-24.
Skoubis, P. D. Matthes, H. W. Walwyn, W. M. Kieffer, B. L. Maidment, N. T.   Naloxone fails to produce conditioned place aversion in mu-opioid receptor knock-out mice Neuroscience, 2001; 106(4): 757-63.
Walwyn, W. M. Ta-Haung, J. Ackerson, L. Maidment, N. T. Edgerton, V. R.   Extracellular glutamate in the dorsal horn of the lumbar spinal cord in the freely moving rat during hindlimb stepping Pharmacol Biochem Behav, 1999; 63(4): 581-8.