Wendy Walwyn
Titles
Member, Brain Research Institute
Adjunct Professor, Psychiatry and Biobehavioral Sciences
Hatos Center for Neuropharmacology
Contact Information
Email
wwalwyn@g.ucla.edu Phone
Fax Number:
(310) 206-7067
Work Phone Number: (310) 206-3231
Work Phone Number: (310) 206-3231
Address
Mailing Address:
MRL Building675 Charles Young Drive
Los Angeles, CA 90095
UNITED STATES
Biography
Publications
A selected list of publications:
Smith Wesley C, Rosenberg Matthew H, Claar Leslie D, Chang Victoria, Shah Sagar N, Walwyn Wendy M, Evans Christopher J, Masmanidis Sotiris C
Frontostriatal Circuit Dynamics Correlate with Cocaine Cue-Evoked
Behavioral Arousal during Early Abstinence
eNeuro,
; 3(3):
.
Storey, G. P.; Gonzalez-Fernandez, G.; Bamford, I. J.; Hur, M.; McKinley, J. W.; Heimbigner, L.; Minasyan, A.; Walwyn, W. M.; Bamford, N. S.
Nicotine Modifies Corticostriatal Plasticity and Amphetamine Rewarding Behaviors in Mice(1,2,3)
eNeuro,
2016; 3(1):
.
Taylor, A. M.; Roberts, K. W.; Pradhan, A. A.; Akbari, H. A.; Walwyn, W.; Lutfy, K.; Carroll, F. I.; Cahill, C. M.; Evans, C. J.
Anti-nociception mediated by a kappa opioid receptor agonist is blocked by a delta receptor agonist
Br J Pharmacol,
2015; 172(2):
691-703.
Marvizon, J. C.; Walwyn, W.; Minasyan, A.; Chen, W.; Taylor, B. K.
Latent sensitization: a model for stress-sensitive chronic pain
Curr Protoc Neurosci,
2015; 71:
9 50 1-9 50 14.
Marvizon, J. C.; Walwyn, W.; Minasyan, A.; Chen, W.; Taylor, B. K.
Latent sensitization: a model for stress-sensitive chronic pain
Curr Protoc Neurosci,
2015; 71:
9 50 1-9 50 14.
Gendron, L.; Mittal, N.; Beaudry, H.; Walwyn, W.
Recent advances on the delta opioid receptor: from trafficking to function
Br J Pharmacol,
2015; 172(2):
403-19.
Chen, W.; Walwyn, W.; Ennes, H. S.; Kim, H.; McRoberts, J. A.; Marvizon, J. C.
BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals
Eur J Neurosci,
2014; 39(9):
1439-54.
Cui, Y.; Ostlund, S. B.; James, A. S.; Park, C. S.; Ge, W.; Roberts, K. W.; Mittal, N.; Murphy, N. P.; Cepeda, C.; Kieffer, B. L.; Levine, M. S.; Jentsch, J. D.; Walwyn, W. M.; Sun, Y. E.; Evans, C. J.; Maidment, N. T.; Yang, X. W.
Targeted expression of mu-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward
Nat Neurosci,
2014; 17(2):
254-61.
Pradhan, A.; Smith, M.; McGuire, B.; Evans, C.; Walwyn, W.
Chronic inflammatory injury results in increased coupling of delta opioid receptors to voltage-gated Ca2+ channels
Mol Pain,
2013; 9:
8.
Weibel, R.; Reiss, D.; Karchewski, L.; Gardon, O.; Matifas, A.; Filliol, D.; Becker, J. A.; Wood, J. N.; Kieffer, B. L.; Gaveriaux-Ruff, C.
Mu opioid receptors on primary afferent nav1.8 neurons contribute to opiate-induced analgesia: insight from conditional knockout mice
PLoS One,
2013; 8(9):
e74706.
Mittal, N.; Tan, M.; Egbuta, O.; Desai, N.; Crawford, C.; Xie, C. W.; Evans, C.; Walwyn, W.
Evidence that behavioral phenotypes of morphine in beta-arr2-/- mice are due to the unmasking of JNK signaling
Neuropsychopharmacology,
2012; 37(8):
1953-62.
Lam, H.; Maga, M.; Pradhan, A.; Evans, C. J.; Maidment, N. T.; Hales, T. G.; Walwyn, W.
Analgesic tone conferred by constitutively active mu opioid receptors in mice lacking beta-arrestin 2
Mol Pain,
2011; 7:
24.
Walwyn, W.; John, S.; Maga, M.; Evans, C. J.; Hales, T. G.
Delta receptors are required for full inhibitory coupling of mu-receptors to voltage-dependent Ca(2+) channels in dorsal root ganglion neurons
Mol Pharmacol,
2009; 76(1):
134-43.
Otoshi, C. K.; Walwyn, W. M.; Tillakaratne, N. J.; Zhong, H.; Roy, R. R.; Edgerton, V. R.
Distribution and localization of 5-HT(1A) receptors in the rat lumbar spinal cord after transection and deafferentation
J Neurotrauma,
2009; 26(4):
575-84.
Walwyn, W. M.; Matsuka, Y.; Arai, D.; Bloom, D. C.; Lam, H.; Tran, C.; Spigelman, I.; Maidment, N. T.
HSV-1-mediated NGF delivery delays nociceptive deficits in a genetic model of diabetic neuropathy
Exp Neurol,
2006; 198(1):
260-70.
Walwyn, W.; Maidment, N. T.; Sanders, M.; Evans, C. J.; Kieffer, B. L.; Hales, T. G.
Induction of delta opioid receptor function by up-regulation of membrane receptors in mouse primary afferent neurons
Mol Pharmacol,
2005; 68(6):
1688-98.
Walwyn, W. M.; Keith, D. E., Jr.; Wei, W.; Tan, A. M.; Xie, C. W.; Evans, C. J.; Kieffer, B. L.; Maidment, N. T.
Functional coupling, desensitization and internalization of virally expressed mu opioid receptors in cultured dorsal root ganglion neurons from mu opioid receptor knockout mice
Neuroscience,
2004; 123(1):
111-21.
Irnaten, M.; Walwyn, W. M.; Wang, J.; Venkatesan, P.; Evans, C.; Chang, K. S.; Andresen, M. C.; Hales, T. G.; Mendelowitz, D.
Pentobarbital enhances GABAergic neurotransmission to cardiac parasympathetic neurons, which is prevented by expression of GABA(A) epsilon subunit
Anesthesiology,
2002; 97(3):
717-24.
Skoubis, P. D.; Matthes, H. W.; Walwyn, W. M.; Kieffer, B. L.; Maidment, N. T.
Naloxone fails to produce conditioned place aversion in mu-opioid receptor knock-out mice
Neuroscience,
2001; 106(4):
757-63.
Walwyn, W. M.; Ta-Haung, J.; Ackerson, L.; Maidment, N. T.; Edgerton, V. R.
Extracellular glutamate in the dorsal horn of the lumbar spinal cord in the freely moving rat during hindlimb stepping
Pharmacol Biochem Behav,
1999; 63(4):
581-8.
Pradhan Amynah A, Perroy Julie, Walwyn Wendy M, Smith Monique L, Vicente-Sanchez Ana, Segura Laura, Bana Alia, Kieffer Brigitte L, Evans Christopher J
Agonist-Specific Recruitment of Arrestin Isoforms Differentially
Modify Delta Opioid Receptor Function
The Journal of neuroscience : the official journal of the Society for Neuroscience,
2016; 36(12):
3541-51.
Walwyn, W. M.; Chen, W.; Kim, H.; Minasyan, A.; Ennes, H. S.; McRoberts, J. A.; Marvizon, J. C.
Sustained Suppression of Hyperalgesia during Latent Sensitization by mu-, delta-, and kappa-opioid receptors and alpha2A Adrenergic Receptors: Role of Constitutive Activity
J Neurosci,
2016; 36(1):
204-21.
Mittal, N.; Roberts, K.; Pal, K.; Bentolila, L. A.; Fultz, E.; Minasyan, A.; Cahill, C.; Pradhan, A.; Conner, D.; DeFea, K.; Evans, C.; Walwyn, W.
Select G-protein-coupled receptors modulate agonist-induced signaling via a ROCK, LIMK, and beta-arrestin 1 pathway
Cell Rep,
2013; 5(4):
1010-21.
James, A. S.; Chen, J. Y.; Cepeda, C.; Mittal, N.; Jentsch, J. D.; Levine, M. S.; Evans, C. J.; Walwyn, W.
Opioid self-administration results in cell-type specific adaptations of striatal medium spiny neurons
Behav Brain Res,
2013; 256:
279-83.
Pradhan, A. A.; Walwyn, W.; Nozaki, C.; Filliol, D.; Erbs, E.; Matifas, A.; Evans, C.; Kieffer, B. L.
Ligand-directed trafficking of the delta-opioid receptor in vivo: two paths toward analgesic tolerance
J Neurosci,
2010; 30(49):
16459-68.
Walwyn, W. M.; Miotto, K. A.; Evans, C. J.
Opioid pharmaceuticals and addiction: the issues, and research directions seeking solutions
Drug Alcohol Depend,
2010; 108(3):
156-65.
Tan, M.; Walwyn, W. M.; Evans, C. J.; Xie, C. W.
p38 MAPK and beta-arrestin 2 mediate functional interactions between endogenous micro-opioid and alpha2A-adrenergic receptors in neurons
J Biol Chem,
2009; 284(10):
6270-81.
Tan, Walwyn, Evans, Xie
p38 map kinase and beta -arrestin 2 mediate functional interactions
between endogenous mu -opioid and alpha 2A-adrenergic receptors in
neurons
The Journal of biological chemistry,
2009;
.
Walwyn, W. Evans, C. J. Hales, T. G.
Beta-arrestin2 and c-Src regulate the constitutive activity and recycling of mu opioid receptors in dorsal root ganglion neurons
J Neurosci,
2007; 27(19):
5092-104.
Walwyn, W.; Evans, C. J.; Hales, T. G.
Beta-arrestin2 and c-Src regulate the constitutive activity and recycling of mu opioid receptors in dorsal root ganglion neurons
J Neurosci,
2007; 27(19):
5092-104.
Walwyn Wendy, Evans Christopher J, Hales Tim G
Beta-arrestin2 and c-Src regulate the constitutive activity and
recycling of mu opioid receptors in dorsal root ganglion neurons
The Journal of neuroscience : the official journal of the Society for Neuroscience,
2007; 27(19):
5092-104.
Walwyn, W. M. Wei, W. Xie, C. W. Chiu, K. Kieffer, B. L. Evans, C. J. Maidment, N. T.
Mu opioid receptor-effector coupling and trafficking in dorsal root ganglia neurons
Neuroscience,
2006; 142(2):
493-503.
Walwyn, W. M.; Wei, W.; Xie, C. W.; Chiu, K.; Kieffer, B. L.; Evans, C. J.; Maidment, N. T.
Mu opioid receptor-effector coupling and trafficking in dorsal root ganglia neurons
Neuroscience,
2006; 142(2):
493-503.
Walwyn, W. M. Matsuka, Y. Arai, D. Bloom, D. C. Lam, H. Tran, C. Spigelman, I. Maidment, N. T.
HSV-1-mediated NGF delivery delays nociceptive deficits in a genetic model of diabetic neuropathy
Exp Neurol,
2006; 198(1):
260-70.
Walwyn, W. Maidment, N. T. Sanders, M. Evans, C. J. Kieffer, B. L. Hales, T. G.
Induction of delta opioid receptor function by up-regulation of membrane receptors in mouse primary afferent neurons
Mol Pharmacol,
2005; 68(6):
1688-98.
Walwyn, W. M. Keith, D. E., Jr. Wei, W. Tan, A. M. Xie, C. W. Evans, C. J. Kieffer, B. L. Maidment, N. T.
Functional coupling, desensitization and internalization of virally expressed mu opioid receptors in cultured dorsal root ganglion neurons from mu opioid receptor knockout mice
Neuroscience,
2004; 123(1):
111-21.
Lutfy, K. Eitan, S. Bryant, C. D. Yang, Y. C. Saliminejad, N. Walwyn, W. Kieffer, B. L. Takeshima, H. Carroll, F. I. Maidment, N. T. Evans, C. J.
Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors
J Neurosci,
2003; 23(32):
10331-7.
Lutfy, K.; Eitan, S.; Bryant, C. D.; Yang, Y. C.; Saliminejad, N.; Walwyn, W.; Kieffer, B. L.; Takeshima, H.; Carroll, F. I.; Maidment, N. T.; Evans, C. J.
Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors
J Neurosci,
2003; 23(32):
10331-7.
Irnaten, M. Walwyn, W. M. Wang, J. Venkatesan, P. Evans, C. Chang, K. S. Andresen, M. C. Hales, T. G. Mendelowitz, D.
Pentobarbital enhances GABAergic neurotransmission to cardiac parasympathetic neurons, which is prevented by expression of GABA(A) epsilon subunit
Anesthesiology,
2002; 97(3):
717-24.
Skoubis, P. D. Matthes, H. W. Walwyn, W. M. Kieffer, B. L. Maidment, N. T.
Naloxone fails to produce conditioned place aversion in mu-opioid receptor knock-out mice
Neuroscience,
2001; 106(4):
757-63.
Walwyn, W. M. Ta-Haung, J. Ackerson, L. Maidment, N. T. Edgerton, V. R.
Extracellular glutamate in the dorsal horn of the lumbar spinal cord in the freely moving rat during hindlimb stepping
Pharmacol Biochem Behav,
1999; 63(4):
581-8.