Walter Ling, M.D.
Titles
Professor, Psychiatry and Biobehavioral Sciences
Co-Director, Integrated Substance Abuse Program
Member, Brain Research Institute
Contact Information
Email
lwalter@ix.netcom.com Phone
Fax Number:
310 312-0552
Work Phone Number: (800) 825-9989
310-267-5888
Work Phone Number: (800) 825-9989
310-267-5888
Address
Mailing Address:
UCLA Integrated Substance Abuse Programs1640 S. Sepulveda Blvd., Suite 200
Los Angeles, CA 90025
UNITED STATES
Biography
Dr. Walter Ling is Professor of Psychiatry and Director of Integrated Substance Abuse Programs (ISAP) at UCLA, one of the foremost substance abuse research groups in the US and worldwide. He is board certified in neurology and psychiatry, is active in research and clinical work, and has been listed in ‘Best Doctors in America’, ‘Best Doctors in the West’ and ‘Best Doctors in Los Angeles’. Doctor Ling’s research in opiate pharmacotherapy provided pivotal information for the approval of LAAM, naltrexone and buprenorphine. His current research includes prescription opiate abuse and dependence, opiate induced hyperalgesia, treatment of pain in opiate-maintained patients, including those treated with buprenorphine, and the role of buprenorphine in the management of pain in these patients. The scope of ISAP’s research has encompassed the development of medications and psychosocial strategies for the treatment of opiate, cocaine, methamphetamine, alcohol and nicotine abuse and dependence. As Principal Investigator of NIDA’s Clinical Trial Network’s Pacific Region Node, Doctor Ling has extended ISAP’s research beyond the US to Asia and the Middle East..Publications
A selected list of publications:
Ling Walter, Casadonte Paul, Bigelow George, Kampman Kyle M, Patkar Ashwin, Bailey Genie L, Rosenthal Richard N, Beebe Katherine L
Buprenorphine implants for treatment of opioid dependence: a
randomized controlled trial
JAMA : the journal of the American Medical Association,
2010; 304(14):
1576-83.
Compton Peggy, Kehoe Priscilla, Sinha Karabi, Torrington Matt A, Ling Walter
Gabapentin improves cold-pressor pain responses in
methadone-maintained patients
Drug and alcohol dependence,
2010; 109(1-3):
213-9.
Ling Walter
Buprenorphine for opioid dependence
Expert review of neurotherapeutics,
2009; 9(5):
609-16.
Shoptaw Steven J, Kao Uyen, Heinzerling Keith, Ling Walter
Treatment for amphetamine withdrawal
Cochrane database of systematic reviews (Online),
2009; 9(2):
CD003021.
Ling Walter, Hillhouse Maureen, Domier Catherine, Doraimani Geetha, Hunter Jeremy, Thomas Christie, Jenkins Jessica, Hasson Albert, Annon Jeffrey, Saxon Andrew, Selzer Jeffrey, Boverman Joshua, Bilangi Richard
Buprenorphine tapering schedule and illicit opioid use
Addiction (Abingdon, England),
2009; 104(2):
256-65.
Yu Elmer, Miotto Karen, Akerele Evaristo, Montgomery Ann, Elkashef Ahmed, Walsh Robert, Montoya Ivan, Fischman Marian W, Collins Joseph, McSherry Frances, Boardman Kathy, Davies David K, O'Brien Charles P, Ling Walter, Kleber Herbert, Herman Barbara H
A Phase 3 placebo-controlled, double-blind, multi-site trial of the
alpha-2-adrenergic agonist, lofexidine, for opioid withdrawal
Drug and alcohol dependence,
2008; 97(1-2):
158-68.
Compton Peggy A, Ling Walter, Torrington Matt A
Lack of effect of chronic dextromethorphan on experimental pain
tolerance in methadone-maintained patients
Addiction biology,
2008; 13(3-4):
393-402.
Shoptaw Steven, Heinzerling Keith G, Rotheram-Fuller Erin, Steward Trevor, Wang Jason, Swanson Aimee-Noelle, De La Garza Richard, Newton Tom, Ling Walter
Randomized, placebo-controlled trial of bupropion for the treatment of
methamphetamine dependence
Drug and alcohol dependence,
2008; 96(3):
222-32.
Humeniuk Rachel, Ali Robert, Babor Thomas F, Farrell Michael, Formigoni Maria L, Jittiwutikarn Jaroon, de Lacerda Roseli B, Ling Walter, Marsden John, Monteiro Maristela, Nhiwatiwa Sekai, Pal Hemraj, Poznyak Vladimir, Simon Sara
Validation of the Alcohol, Smoking And Substance Involvement Screening
Test (ASSIST)
Addiction (Abingdon, England),
2008; 103(6):
1039-47.
Yu Elmer, Miotto Karen, Akerele Evaristo, O'Brien Charles P, Ling Walter, Kleber Herbert, Fischman Marian W, Elkashef Ahmed, Herman Barbara H, Al-Ghananeem Abeer M
Clinical pharmacokinetics of lofexidine, the alpha 2-adrenergic
receptor agonist, in opiate addicts plasma using a highly sensitive
liquid chromatography tandem mass spectrometric analysis
The American journal of drug and alcohol abuse,
2008; 34(5):
611-6.
Astrup Arne, Greenway Frank L, Ling Walter, Pedicone Lisa, Lachowicz Jean, Strader Catherine D, Kwan Rudolf, Kwan Rudolf
Randomized controlled trials of the D1/D5 antagonist ecopipam for
weight loss in obese subjects
Obesity (Silver Spring, Md.),
2007; 15(7):
1717-31.
Rawson Richard A, Gonzales Rachel, McCann Michael, Ling Walter
Use of methamphetamine by young people: is there reason for concern?
Addiction (Abingdon, England),
2007; 102(7):
1021-2.
Compton Peggy, Ling Walter, Chiang C Nora, Moody David E, Huber Alice, Ling Debbie, Charuvastra Charles
Pharmacokinetics of buprenorphine: a comparison of sublingual tablet
versus liquid after chronic dosing
Journal of addiction medicine,
2007; 1(2):
88-95.
Torrington Matthew, Domier Catherine P, Hillhouse Maureen, Ling Walter
Buprenorphine 101: treating opioid dependence with buprenorphine in an
office-based setting
Journal of addictive diseases,
2007; 26(3):
93-9.
Elkashef Ahmed, Rawson Richard A, Smith Edwina, Pearce Valerie, Flammino Frank, Campbell Jan, Donovick Roger, Gorodetzky Charles, Haning William, Mawhinney Joseph, McCann Michael, Weis Dennis, Williams Lorie, Ling Walter, Vocci Frank
The NIDA Methamphetamine Clinical Trials Group: a strategy to increase
clinical trials research capacity
Addiction (Abingdon, England),
2007; 102 Suppl 1(2):
107-13.
Heinzerling Keith G, Shoptaw Steven, Peck James A, Yang Xiaowei, Liu Juanmei, Roll John, Ling Walter
Randomized, placebo-controlled trial of baclofen and gabapentin for
the treatment of methamphetamine dependence
Drug and alcohol dependence,
2006; 85(3):
177-84.
Shoptaw Steven, Huber Alice, Peck James, Yang Xiaowei, Liu Juanmei, Jeff Dang Juanmei, Roll John, Shapiro Benjamin, Rotheram-Fuller Erin, Ling Walter
Randomized, placebo-controlled trial of sertraline and contingency
management for the treatment of methamphetamine dependence
Drug and alcohol dependence,
2006; 85(1):
12-8.
Venneman Sandy, Leuchter Andrew, Bartzokis George, Beckson Mace, Simon Sara L, Schaefer Melodie, Rawson Richard, Newton Tom, Cook Ian A, Uijtdehaage Sebastian, Ling Walter
Variation in neurophysiological function and evidence of quantitative
electroencephalogram discordance: predicting cocaine-dependent
treatment attrition
The Journal of neuropsychiatry and clinical neurosciences,
2006; 18(2):
208-16.
Rawson Richard A, McCann Michael J, Flammino Frank, Shoptaw Steven, Miotto Karen, Reiber Chris, Ling Walter
A comparison of contingency management and cognitive-behavioral
approaches for stimulant-dependent individuals
Addiction (Abingdon, England),
2006; 101(2):
267-74.
Athanasos Peter, Smith Charlotte S, White Jason M, Somogyi Andrew A, Bochner Felix, Ling Walter
Methadone maintenance patients are cross-tolerant to the
antinociceptive effects of very high plasma morphine concentrations
Pain,
2006; 120(3):
267-75.
London Edythe D, Berman Steven M, Voytek Bradley, Simon Sara L, Mandelkern Mark A, Monterosso John, Thompson Paul M, Brody Arthur L, Geaga Jennifer A, Hong Michael S, Hayashi Kiralee M, Rawson Richard A, Ling Walter
Cerebral metabolic dysfunction and impaired vigilance in recently
abstinent methamphetamine abusers
Biological psychiatry,
2005; 58(10):
770-8.
Vocci Frank, Ling Walter
Medications development: successes and challenges
Pharmacology & therapeutics,
2005; 108(1):
94-108.
Newton Thomas F, Kalechstein Ari D, De La Garza Richard, Cutting Daniel J, Ling Walter
Apathy predicts hedonic but not craving response to cocaine
Pharmacology, biochemistry, and behavior,
2005; 82(1):
236-40.
Ling Walter, Amass Leslie, Shoptaw Steve, Annon Jeffrey J, Hillhouse Maureen, Babcock Dean, Brigham Greg, Harrer Judy, Reid Malcolm, Muir Joan, Buchan Betty, Orr Debbie, Woody George, Krejci Jonathan, Ziedonis Douglas, Ziedonis Douglas
A multi-center randomized trial of buprenorphine-naloxone versus
clonidine for opioid detoxification: findings from the National
Institute on Drug Abuse Clinical Trials Network
Addiction (Abingdon, England),
2005; 100(8):
1090-100.
Voytek Bradley, Berman Steven M, Hassid B Daniel, Simon Sara L, Mandelkern Mark A, Brody Arthur L, Monterosso John, Ling Walter, London Edythe D
Differences in regional brain metabolism associated with marijuana
abuse in methamphetamine abusers
Synapse (New York, N.Y.),
2005; 57(2):
113-5.
Raisch Dennis W, Fudala Paul J, Saxon Andrew J, Walsh Robert, Casadonte Paul, Ling Walter, Johnson Bankole A, Malkerneker Usha, Ordorica Patricia, Williford William O, Sather Mike R
Pharmacists' and technicians' perceptions and attitudes toward
dispensing buprenorphine/ naloxone to patients with opioid dependence
Journal of the American Pharmacists Association : JAPhA,
2005; 45(1):
23-32.
Shoptaw Steven, Watson Donnie W, Reiber Chris, Rawson Richard A, Montgomery Margaret A, Majewska Maria D, Ling Walter
Randomized controlled pilot trial of cabergoline, hydergine and
levodopa/carbidopa: Los Angeles Cocaine Rapid Efficacy Screening Trial
(CREST)
Addiction (Abingdon, England),
2005; 100 Suppl 1(2):
78-90.
Humeniuk Rachel, Ali Robert, Ling Walter
Substance use and treatment options in Cambodia
Drug and alcohol review,
2004; 23(3):
365-7.
Newton Thomas F, Kalechstein Ari D, Duran Sonia, Vansluis Nicolette, Ling Walter
Methamphetamine abstinence syndrome: preliminary findings
The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions,
2004; 13(3):
248-55.
Thompson Paul M, Hayashi Kiralee M, Simon Sara L, Geaga Jennifer A, Hong Michael S, Sui Yihong, Lee Jessica Y, Toga Arthur W, Ling Walter, London Edythe D
Structural abnormalities in the brains of human subjects who use
methamphetamine
The Journal of neuroscience : the official journal of the Society for Neuroscience,
2004; 24(26):
6028-36.
Ling Walter, Cunningham-Rathner Jerry, Rawson Richard
Diffusion of substance abuse treatment: will buprenorphine be a
success?
Journal of psychoactive drugs,
2004; Suppl 2(2):
115-7.
Shoptaw Steve, Majewska Maria Dorota, Wilkins Jeffery, Twitchell Geoffrey, Yang Xiaowei, Ling Walter
Participants receiving dehydroepiandrosterone during treatment for
cocaine dependence show high rates of cocaine use in a
placebo-controlled pilot study
Experimental and clinical psychopharmacology,
2004; 12(2):
126-35.
Amass Leslie, Ling Walter, Freese Thomas E, Reiber Chris, Annon Jeffrey J, Cohen Allan J, McCarty Dennis, Reid Malcolm S, Brown Lawrence S, Clark Cynthia, Ziedonis Douglas M, Krejci Jonathan, Stine Susan, Winhusen Theresa, Brigham Greg, Babcock Dean, Muir Joan A, Buchan Betty J, Horton Terry
Bringing buprenorphine-naloxone detoxification to community treatment
providers: the NIDA Clinical Trials Network field experience
The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions,
2004; 13 Suppl 1(3):
S42-66.
Newton Thomas F, Kalechstein Ari D, Hardy David J, Cook Ian A, Nestor Liam, Ling Walter, Leuchter Andrew F
Association between quantitative EEG and neurocognition in
methamphetamine-dependent volunteers
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology,
2004; 115(1):
194-8.
London Edythe D, Simon Sara L, Berman Steven M, Mandelkern Mark A, Lichtman Aaron M, Bramen Jennifer, Shinn Ann K, Miotto Karen, Learn Jennifer, Dong Yun, Matochik John A, Kurian Varughese, Newton Thomas, Woods Roger, Rawson Richard, Ling Walter
Mood disturbances and regional cerebral metabolic abnormalities in
recently abstinent methamphetamine abusers
Archives of general psychiatry,
2004; 61(1):
73-84.
Shoptaw Steven, Yang Xiaowei, Rotheram-Fuller Erin J, Hsieh Ya-Ching M, Kintaudi Prudencia C, Charuvastra V C, Ling Walter
Randomized placebo-controlled trial of baclofen for cocaine
dependence: preliminary effects for individuals with chronic patterns
of cocaine use
The Journal of clinical psychiatry,
2003; 64(12):
1440-8.
Compton Peggy, Charuvastra V C, Ling Walter
Effect of oral ketorolac and gender on human cold pressor pain
tolerance
Clinical and experimental pharmacology & physiology,
2003; 30(10):
759-63.
Charles Bradley K, Day Jayme E, Rollins Douglas E, Andrenyak David, Ling Walter, Wilkins Diana G
Opiate recidivism in a drug-treatment program: comparison of hair and
urine data
Journal of analytical toxicology,
2003; 27(7):
412-28.
Fudala Paul J, Bridge T Peter, Herbert Susan, Williford William O, Chiang C Nora, Jones Karen, Collins Joseph, Raisch Dennis, Casadonte Paul, Goldsmith R Jeffrey, Ling Walter, Malkerneker Usha, McNicholas Laura, Renner John, Stine Susan, Tusel Donald, Tusel Donald
Office-based treatment of opiate addiction with a sublingual-tablet
formulation of buprenorphine and naloxone
The New England journal of medicine,
2003; 349(10):
949-58.
Newton Thomas F, Kalechstein Ari D, Tervo Kari E, Ling Walter
Irritability following abstinence from cocaine predicts euphoric
effects of cocaine administration
Addictive behaviors,
2003; 28(4):
817-21.
Ling Walter, Wesson Donald R
Clinical efficacy of buprenorphine: comparisons to methadone and
placebo
Drug and alcohol dependence,
2003; 70(2 Suppl):
S49-57.
Lopatko Olga V, White Jason M, Huber Alice, Ling Walter
Opioid effects and opioid withdrawal during a 24 h dosing interval in
patients maintained on buprenorphine
Drug and alcohol dependence,
2003; 69(3):
317-22.
Wesson Donald R, Ling Walter
The Clinical Opiate Withdrawal Scale (COWS)
Journal of psychoactive drugs,
2003; 35(2):
253-9.
Ling Walter, Rawson Richard A, Compton Margaret
Clinical treatment of opioid addiction and dependence
Methods in molecular medicine,
2003; 84(3):
285-95.
Rawson Richard A, Marinelli-Casey Patricia, Ling Walter
Dancing with strangers: will U.S. substance abuse practice and
research organizations build mutually productive relationships?
Addictive behaviors,
2003; 27(6):
941-9.
Newton Thomas F, Cook Ian A, Kalechstein Ari D, Duran Sonia, Monroy Franz, Ling Walter, Leuchter Andrew F
Quantitative EEG abnormalities in recently abstinent methamphetamine
dependent individuals
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology,
2003; 114(3):
410-5.
Shoptaw Steve, Rotheram-Fuller Erin, Yang Xiaowei, Frosch Dominick, Nahom Debbie, Jarvik Murray E, Rawson Richard A, Ling Walter
Smoking cessation in methadone maintenance
Addiction (Abingdon, England),
2002; 97(10):
1317-28; discussion 1325.
Rawson Richard A, Huber Alice, McCann Michael, Shoptaw Steven, Farabee David, Reiber Chris, Ling Walter
A comparison of contingency management and cognitive-behavioral
approaches during methadone maintenance treatment for cocaine
dependence
Archives of general psychiatry,
2002; 59(9):
817-24.
Ling Walter, Smith David
Buprenorphine: blending practice and research
Journal of substance abuse treatment,
2002; 23(2):
87-92.
Shoptaw Steve, Kintaudi P C, Charuvastra Charles, Ling Walter
A screening trial of amantadine as a medication for cocaine
dependence
Drug and alcohol dependence,
2002; 66(3):
217-24.
Sim Tiffanie, Simon Sara L, Domier Catherine P, Richardson Kimberly, Rawson Richard A, Ling Walter
Cognitive deficits among methamphetamine users with attention deficit
hyperactivity disorder symptomatology
Journal of addictive diseases,
2002; 21(1):
75-89.
Simon Sara L, Domier Catherine P, Sim Tiffanie, Richardson Kimberly, Rawson Richard A, Ling Walter
Cognitive performance of current methamphetamine and cocaine abusers
Journal of addictive diseases,
2002; 21(1):
61-74.
Ling Walter
Cynthia's Dilemma
The American journal of bioethics : AJOB,
2002; 2(2):
55-6.
Miotto Karen, McCann Michael, Basch Janice, Rawson Richard, Ling Walter
Naltrexone and dysphoria: fact or myth?
The American journal on addictions / American Academy of Psychiatrists in Alcoholism and Addictions,
2002; 11(2):
151-60.
Rawson Richard A, Anglin M Douglas, Ling Walter
Will the methamphetamine problem go away?
Journal of addictive diseases,
2002; 21(1):
5-19.