Joseph Watson, Ph.D.

Professor, Psychiatry and Biobehavioral Sciences

Professor In-Residence, Jane and Terry Semel Institute for Neuroscience and Human Behavior

Biography

Barry Joshua, Sarafian Theodore A, Watson Joseph B, Cepeda Carlos, Levine Michael S   Mechanisms underlying the enhancement of γ-aminobutyric acid responses in the external globus pallidus of R6/2 Huntington's disease model mice Journal of neuroscience research, 2020; 98(11): 2349-2356.

Sarafian Theodore A, Yacoub Amneh, Kunz Anastasia, Aranki Burkan, Serobyan Grigor, Cohn Whitaker, Whitelegge Julian P, Watson Joseph B   Enhanced mitochondrial inhibition by 3,4-dihydroxyphenyl-acetaldehyde (DOPAL)-oligomerized α-synuclein Journal of neuroscience research, 2019; 97(12): 1689-1705.

Sarafian Theodore A, Littlejohn Kaitlyn, Yuan Sarah, Fernandez Charlene, Cilluffo Marianne, Koo Bon-Kyung, Whitelegge Julian P, Watson Joseph B   Stimulation of synaptoneurosome glutamate release by monomeric and fibrillated α-synuclein Journal of neuroscience research, 2017; 95(9): 1871-1887.

Cepeda Carlos, Galvan Laurie, Holley Sandra M, Rao Shilpa P, André Véronique M, Botelho Elian P, Chen Jane Y, Watson Joseph B, Deisseroth Karl, Levine Michael S   Multiple sources of striatal inhibition are differentially affected in Huntington's disease mouse models The Journal of neuroscience : the official journal of the Society for Neuroscience, 2013; 33(17): 7393-406.

Sarafian Theodore A, Ryan Christopher M, Souda Puneet, Masliah Eliezer, Kar Upendra K, Vinters Harry V, Mathern Gary W, Faull Kym F, Whitelegge Julian P, Watson Joseph B   Impairment of mitochondria in adult mouse brain overexpressing predominantly full-length, N-terminally acetylated human α-synuclein PloS one, 2013; 8(5): e63557.

Chang Julia W, Arnold Monica M, Rozenbaum Anna, Caputo Anna, Schweizer Felix E, Huynh My, Mathern Gary W, Sarafian Theodore A, Watson Joseph B   Synaptoneurosome micromethod for fractionation of mouse and human brain, and primary neuronal cultures Journal of neuroscience methods, 2012; 211(2): 289-95.

Romero-Calderón Rafael, O'Hare Elizabeth D, Suthana Nanthia A, Scott-Van Zeeland Ashley A, Rizk-Jackson Angela, Attar Aida, Madsen Sarah K, Ghiani Cristina A, Evans Christopher J, Watson Joseph B   Project brainstorm: using neuroscience to connect college students with local schools PLoS biology, 2012; 10(4): e1001310.

Cummings Damian M, Alaghband Yasaman, Hickey Miriam A, Joshi Prasad R, Hong S Candice, Zhu Chunni, Ando Timothy K, André Véronique M, Cepeda Carlos, Watson Joseph B, Levine Michael S   A critical window of CAG repeat-length correlates with phenotype severity in the R6/2 mouse model of Huntington's disease Journal of neurophysiology, 2012; 107(2): 677-91.

Cepeda Carlos, Cummings Damian M, Hickey Miriam A, Kleiman-Weiner Max, Chen Jane Y, Watson Joseph B, Levine Michael S   Rescuing the Corticostriatal Synaptic Disconnection in the R6/2 Mouse Model of Huntington's Disease: Exercise, Adenosine Receptors and Ampakines PLoS currents, 2010; 2(2): .

Watson J B, Hatami A, David H, Masliah E, Roberts K, Evans C E, Levine M S   Alterations in corticostriatal synaptic plasticity in mice overexpressing human alpha-synuclein Neuroscience, 2009; 159(2): 501-13.

Watson J B, Arnold M M, Ho Y-S, O'Dell T J   Age-dependent modulation of hippocampal long-term potentiation by antioxidant enzymes Journal of neuroscience research, 2006; 84(7): 1564-74.

Zhao Danyun, Watson Joseph B, Xie Cui-Wei   Amyloid beta prevents activation of calcium/calmodulin-dependent protein kinase II and AMPA receptor phosphorylation during hippocampal long-term potentiation Journal of neurophysiology, 2004; 92(5): 2853-8.

Chotiner J K, Khorasani H, Nairn A C, O'Dell T J, Watson J B   Adenylyl cyclase-dependent form of chemical long-term potentiation triggers translational regulation at the elongation step Neuroscience, 2003; 116(3): 743-52.

Watson J B, Khorasani H, Persson A, Huang K-P, Huang F L, O'Dell T J   Age-related deficits in long-term potentiation are insensitive to hydrogen peroxide: coincidence with enhanced autophosphorylation of Ca2+/calmodulin-dependent protein kinase II Journal of neuroscience research, 2002; 70(3): 298-308.

Cepeda Carlos, Crawford Cynthia A, Margulies Jody E, Watson Joseph B, Levine Michael S, Cohen Randy W   Enhanced epileptogenic susceptibility in a genetic model of reactive synaptogenesis: the spastic Han-Wistar rat Developmental neuroscience, 2002; 24(4): 262-71.

Watson, J.B.   Subtractive cDNA Hybridization and Brain: Then, Now, and Tomorrow, Handbook of Molecular-Genetic Techniques for Brain and Behavior Research (Techniques in the Behavior, 1999; Vol. 13: 189-199.

Makhinson M, Chotiner J K, Watson J B, O'Dell T J   Adenylyl cyclase activation modulates activity-dependent changes in synaptic strength and Ca2+/calmodulin-dependent kinase II autophosphorylation The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999; 19(7): 2500-10.

Johnson M W, Chotiner J K, Watson J B   Isolation and characterization of synaptoneurosomes from single rat hippocampal slices Journal of neuroscience methods, 1997; 77(2): 151-6.

Chang, JW Schumacher, E Coulter, PM Vinters, HV Watson, JB   Dendritic translocation of RC3/neurogranin mRNA in normal aging, Alzheimer disease and fronto-temporal dementia Journal of neuropathology and experimental neurology. , 1997; 56(10): 1105-18.