James Jentsch, Ph.D.


Professor, Psychology

Psychiatry and Biobehavioral Sciences

Behavioral Neuroscience

Associate Director for Research, Brain Research Institute

Associate Professor, Psychiatry and Biobehavioral Sciences

Member, Center for Addictive Behaviors

Contact Information

Office Phone Number: 310-825-8258

Work Address:

Franz Hall
Los Angeles, CA 90095


Dr. Jentsch received his BA in Behavioral Biology from the Johns Hopkins University and his DPhil in Neurobiology from the Yale University School of Medicine. He further completed post-doctoral training in neuroscience at the University of Pittsburgh before joining the faculty at UCLA in 2001.


A selected list of publications:

Groman Stephanie M, Morales Angelica M, Lee Buyean, London Edythe D, Jentsch James David   Methamphetamine-induced increases in putamen gray matter associate with inhibitory control Psychopharmacology, 2013; 229(3): 527-38.
James Alex S, Chen Jane Y, Cepeda Carlos, Mittal Nitish, Jentsch James David, Levine Michael S, Evans Christopher J, Walwyn Wendy   Opioid self-administration results in cell-type specific adaptations of striatal medium spiny neurons Behavioural brain research, 2013; 256C(3): 279-283.
Groman Stephanie M, James Alex S, Seu Emanuele, Crawford Maverick A, Harpster Sandra N, Jentsch James David   Monoamine levels within the orbitofrontal cortex and putamen interact to predict reversal learning performance Biological psychiatry, 2013; 73(8): 756-62.
Floresco Stan B, Jentsch James D   Pharmacological enhancement of memory and executive functioning in laboratory animals Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2011; 36(1): 227-50.
Jentsch James David, Woods Jason A, Groman Stephanie M, Seu Emanuele   Behavioral characteristics and neural mechanisms mediating performance in a rodent version of the Balloon Analog Risk Task Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010; 35(8): 1797-806.
Jentsch James David, Trantham-Davidson Heather, Jairl Corey, Tinsley Matthew, Cannon Tyrone D, Lavin Antonieta   Dysbindin modulates prefrontal cortical glutamatergic circuits and working memory function in mice Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2009; 34(12): 2601-8.
Jasinska, Service, Choi, Deyoung, Grujic, Kong, Jorgensen, Bailey, Breidenthal, Fairbanks, Woods, Jentsch, Freimer   Identification of Brain Transcriptional Variation Reproduced in Peripheral Blood: an Approach for Mapping Brain Expression Traits Human molecular genetics, 2009; .
Groman Stephanie M, James Alex S, Jentsch J David   Poor response inhibition: at the nexus between substance abuse and attention deficit/hyperactivity disorder Neuroscience and biobehavioral reviews, 2009; 33(5): 690-8.
Jentsch J David, Aarde Shawn M, Seu Emanuele   Effects of atomoxetine and methylphenidate on performance of a lateralized reaction time task in rats Psychopharmacology, 2009; 202(1-3): 497-504.
Seu Emanuele, Lang Andrew, Rivera Ronald J, Jentsch J David   Inhibition of the norepinephrine transporter improves behavioral flexibility in rats and monkeys Psychopharmacology, 2009; 202(1-3): 505-19.
Bilder J David, Sabb J David, Cannon J David, London J David, Jentsch J David, Parker J David, Poldrack J David, Evans J David, Freimer J David   Phenomics: The systematic study of phenotypes on a genome-wide scale Neuroscience, 2009; 33(5): .
Jentsch J David, Sanchez Diana, Elsworth John D, Roth Robert H   Clonidine and guanfacine attenuate phencyclidine-induced dopamine overflow in rat prefrontal cortex: mediating influence of the alpha-2A adrenoceptor subtype Brain research, 2008; 1246(1-3): 41-6.
Kalechstein Ari D, Jentsch J David, Kantak Kathleen M   Stimulant-associated cognitive abnormalities: mechanisms and impact on reward-related behavior and addiction Drug and alcohol dependence, 2008; 97(3): 276-80.
Elsworth John D, Jentsch J David, Morrow Bret A, Redmond D Eugene, Roth Robert H   Clozapine normalizes prefrontal cortex dopamine transmission in monkeys subchronically exposed to phencyclidine Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2008; 33(3): 491-6.
James Alex S, Groman Stephanie M, Seu Emanuele, Jorgensen Matthew, Fairbanks Lynn A, Jentsch J David   Dimensions of impulsivity are associated with poor spatial working memory performance in monkeys The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007; 27(52): 14358-64.
Olausson Peter, Jentsch J David, Krueger Dilja D, Tronson Natalie C, Nairn Angus C, Taylor Jane R   Orbitofrontal cortex and cognitive-motivational impairments in psychostimulant addiction: evidence from experiments in the non-human primate Annals of the New York Academy of Sciences, 2007; 1121(52): 610-38.
Li Weidong, Zhou Yu, Jentsch J David, Brown Robert A M, Tian Xiaoli, Ehninger Dan, Hennah William, Peltonen Leena, Lönnqvist Jouko, Huttunen Matti O, Kaprio Jaakko, Trachtenberg Joshua T, Silva Alcino J, Cannon Tyrone D   Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice Proceedings of the National Academy of Sciences of the United States of America, 2007; 104(46): 18280-5.
Lee Buyean, Groman Stephanie, London Edythe D, Jentsch James David   Dopamine D2/D3 receptors play a specific role in the reversal of a learned visual discrimination in monkeys Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2007; 32(10): 2125-34.
Olausson Peter, Jentsch J David, Tronson Natalie, Neve Rachel L, Nestler Eric J, Taylor Jane R   DeltaFosB in the nucleus accumbens regulates food-reinforced instrumental behavior and motivation The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006; 26(36): 9196-204.
Moore Holly, Jentsch J David, Ghajarnia Mehdi, Geyer Mark A, Grace Anthony A   A neurobehavioral systems analysis of adult rats exposed to methylazoxymethanol acetate on E17: implications for the neuropathology of schizophrenia Biological psychiatry, 2006; 60(3): 253-64.
Aarde Shawn M, Jentsch J David   Haploinsufficiency of the arginine-vasopressin gene is associated with poor spatial working memory performance in rats Hormones and behavior, 2006; 49(4): 501-8.
Li Weidong, Cui Yijun, Kushner Steven A, Brown Robert A M, Jentsch J David, Frankland Paul W, Cannon Tyrone D, Silva Alcino J   The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1 Current biology : CB, 2005; 15(21): 1961-7.
Lue Yanhe, Jentsch J David, Wang Christina, Rao P Nagesh, Hikim Amiya P Sinha, Salameh Wael, Swerdloff Ronald S   XXY mice exhibit gonadal and behavioral phenotypes similar to Klinefelter syndrome Endocrinology, 2005; 146(9): 4148-54.
Marrs William, Kuperman Julie, Avedian Tahlin, Roth Robert H, Jentsch J David   Alpha-2 adrenoceptor activation inhibits phencyclidine-induced deficits of spatial working memory in rats Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2005; 30(8): 1500-10.
Jentsch J David   Impaired visuospatial divided attention in the spontaneously hypertensive rat Behavioural brain research, 2005; 157(2): 323-30.
Arguello P Alexander, Jentsch J David   Cannabinoid CB1 receptor-mediated impairment of visuospatial attention in the rat Psychopharmacology, 2004; 177(1-2): 141-50.