Itzhak Fried, M.D.
Titles
Director, Epilepsy Surgery
Professor, Neurosurgery
Psychiatry and Biobehavioral Sciences
Jane and Terry Semel Institute for Neuroscience and Human Behavior
Member, Brain Research Institute
Neuroscience GPB Home Area
Contact Information
Email
ifried@mednet.ucla.edu Phone
Work Phone Number:
(310) 825-8409
Address
Mailing Address:
UCLA Med-NeuroBOX 957039, 18-225 NPI
Los Angeles, CA 90095
UNITED STATES
Biography
Professor of Neurosurgery and Psychiatry and Biobehavioral Sciences and Director of the Epilepsy Surgery Program. Dr. Itzhak Fried's research and clinical work is dedicated to the treatment of intractable seizure disorders and epilepsy and to the study of human memory from single neuron level to clinical intervention .Publications
A selected list of publications:
Suthana Nanthia, Fried Itzhak
Percepts to recollections: insights from single neuron recordings in
the human brain
Trends in cognitive sciences,
2012;
.
Medvedovsky Mordekhay, Taulu Samu, Gaily Eija, Metsähonkala Eeva-Liisa, Mäkelä Jyrki P, Ekstein Dana, Kipervasser Svetlana, Neufeld Miri Y, Kramer Uri, Blomstedt Göran, Fried Itzhak, Karppinen Atte, Veshchev Igor, Roivainen Reina, Ben-Zeev Bruria, Goldberg-Stern Hadassah, Wilenius Juha, Paetau Ritva
Sensitivity and specificity of seizure-onset zone estimation by ictal
magnetoencephalography
Epilepsia,
2012;
.
Engel Jerome, McDermott Michael P, Wiebe Samuel, Langfitt John T, Stern John M, Dewar Sandra, Sperling Michael R, Gardiner Irenita, Erba Giuseppe, Fried Itzhak, Jacobs Margaret, Vinters Harry V, Mintzer Scott, Kieburtz Karl, Kieburtz Karl
Early surgical therapy for drug-resistant temporal lobe epilepsy: a
randomized trial
JAMA : the journal of the American Medical Association,
2012; 307(9):
922-30.
Tankus Ariel, Fried Itzhak
Visuomotor coordination and motor representation by human temporal
lobe neurons
Journal of cognitive neuroscience,
2012; 24(3):
600-10.
Suthana Nanthia, Haneef Zulfi, Stern John, Mukamel Roy, Behnke Eric, Knowlton Barbara, Fried Itzhak
Memory enhancement and deep-brain stimulation of the entorhinal area
The New England journal of medicine,
2012; 366(6):
502-10.
Staba Richard J, Ekstrom Arne D, Suthana Nanthia A, Burggren Alison, Fried Itzhak, Engel Jerome, Bookheimer Susan Y
Gray matter loss correlates with mesial temporal lobe neuronal
hyperexcitability inside the human seizure-onset zone
Epilepsia,
2012; 53(1):
25-34.
Mukamel Roy, Fried Itzhak
Human intracranial recordings and cognitive neuroscience
Annual review of psychology,
2012; 63(6):
511-37.
Mukamel Roy, Nir Yuval, Harel Michal, Arieli Amos, Malach Rafael, Fried Itzhak
Invariance of firing rate and field potential dynamics to stimulus
modulation rate in human auditory cortex
Human brain mapping,
2011; 32(8):
1181-93.
Fried Itzhak, Mukamel Roy, Kreiman Gabriel
Internally generated preactivation of single neurons in human medial
frontal cortex predicts volition
Neuron,
2011; 69(3):
548-62.
Mukamel Roy, Ekstrom Arne D, Kaplan Jonas, Iacoboni Marco, Fried Itzhak
Single-neuron responses in humans during execution and observation of
actions
Current biology : CB,
2010; 20(8):
750-6.
Upchurch Kristen, Stern John M, Salamon Noriko, Dewar Sandra, Engel Jerome, Vinters Harry V, Fried Itzhak
Epileptogenic temporal cavernous malformations: operative strategies
and postoperative seizure outcomes
Seizure : the journal of the British Epilepsy Association,
2010; 19(2):
120-8.
Engel Jerome, Akhtari Massoud, Bragin Anatol, Fried Itzhak, Ogren Jennifer A, Staba Richard J, Salamon Noriko, Thompson Paul M
New approaches to structural and functional imaging in focal epilepsy
Epilepsia,
2010; 51 Suppl 1(2):
83-6.
Viskontas Indre V, Quiroga Rodrigo Quian, Fried Itzhak
Human medial temporal lobe neurons respond preferentially to
personally relevant images
Proceedings of the National Academy of Sciences of the United States of America,
2009; 106(50):
21329-34.
Ogren Jennifer A, Wilson Charles L, Bragin Anatol, Lin Jack J, Salamon Noriko, Dutton Rebecca A, Luders Eileen, Fields Tony A, Fried Itzhak, Toga Arthur W, Thompson Paul M, Engel Jerome, Staba Richard J
Three-dimensional surface maps link local atrophy and fast ripples in
human epileptic hippocampus
Annals of neurology,
2009; 66(6):
783-91.
Tankus Ariel, Yeshurun Yehezkel, Fried Itzhak
An automatic measure for classifying clusters of suspected spikes into
single cells versus multiunits
Journal of neural engineering,
2009; 6(5):
056001.
Lerner Jason T, Salamon Noriko, Hauptman Jason S, Velasco Tonicarlo R, Hemb Marta, Wu Joyce Y, Sankar Raman, Donald Shields W, Engel Jerome, Fried Itzhak, Cepeda Carlos, Andre Veronique M, Levine Michael S, Miyata Hajime, Yong William H, Vinters Harry V, Mathern Gary W
Assessment and surgical outcomes for mild type I and severe type II
cortical dysplasia: a critical review and the UCLA experience
Epilepsia,
2009; 50(6):
1310-35.
Tankus Ariel, Yeshurun Yehezkel, Flash Tamar, Fried Itzhak
Encoding of speed and direction of movement in the human supplementary
motor area
Journal of neurosurgery,
2009; 110(6):
1304-16.
Ekstrom Arne, Suthana Nanthia, Behnke Eric, Salamon Noriko, Bookheimer Susan, Fried Itzhak
High-resolution depth electrode localization and imaging in patients
with pharmacologically intractable epilepsy
Journal of neurosurgery,
2008; 108(4):
812-5.
Staba Richard J, Frighetto Leonardo, Behnke Eric J, Mathern Gary W, Fields Tony, Bragin Anatol, Ogren Jennifer, Fried Itzhak, Wilson Charles L, Engel Jerome
Increased fast ripple to ripple ratios correlate with reduced
hippocampal volumes and neuron loss in temporal lobe epilepsy
patients
Epilepsia,
2007; 48(11):
2130-8.
Viskontas Indre V, Ekstrom Arne D, Wilson Charles L, Fried Itzhak
Characterizing interneuron and pyramidal cells in the human medial
temporal lobe in vivo using extracellular recordings
Hippocampus,
2007; 17(1):
49-57.
Ekstrom Arne, Viskontas Indre, Kahana Michael, Jacobs Josh, Upchurch Kristen, Bookheimer Susan, Fried Itzhak
Contrasting roles of neural firing rate and local field potentials in
human memory
Hippocampus,
2007; 17(8):
606-17.
Viskontas Indre V, Knowlton Barbara J, Steinmetz Peter N, Fried Itzhak
Differences in mnemonic processing by neurons in the human hippocampus
and parahippocampal regions
Journal of cognitive neuroscience,
2006; 18(10):
1654-62.
Zeitzer Jamie M, Morales-Villagran Alberto, Maidment Nigel T, Behnke Eric J, Ackerson Larry C, Lopez-Rodriguez Faustino, Fried Itzhak, Engel Jerome, Wilson Charles L
Extracellular adenosine in the human brain during sleep and sleep
deprivation: an in vivo microdialysis study
Sleep,
2006; 29(4):
455-61.
Schrader Lara M, Stern John M, Wilson Charles L, Fields Tony A, Salamon Noriko, Nuwer Marc R, Vespa Paul M, Fried Itzhak
Low frequency electrical stimulation through subdural electrodes in a
case of refractory status epilepticus
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology,
2006; 117(4):
781-8.
Bragin Anatol, Wilson Charles L, Fields Tony, Fried Itzhak, Engel Jerome
Analysis of seizure onset on the basis of wideband EEG recordings
Epilepsia,
2005; 46 Suppl 5(5736):
59-63.
Ekstrom Arne D, Caplan Jeremy B, Ho Emily, Shattuck Kirk, Fried Itzhak, Kahana Michael J
Human hippocampal theta activity during virtual navigation
Hippocampus,
2005; 15(7):
881-9.
Frazee John, Fried Itzhak, Kawamoto Henry, Lazareff Jorge, Nieto Jaime, Patel Swati, Urata Mark, van de Wiele Barbara
The separation of Guatemalan craniopagus twins
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery,
2004; 20(8-9):
593-600.
Staba Richard J, Wilson Charles L, Bragin Anatol, Jhung Donald, Fried Itzhak, Engel Jerome
High-frequency oscillations recorded in human medial temporal lobe
during sleep
Annals of neurology,
2004; 56(1):
108-15.
Amador Nelly, Fried Itzhak
Single-neuron activity in the human supplementary motor area
underlying preparation for action
Journal of neurosurgery,
2004; 100(2):
250-9.
Cornford Eain M, Shamsa Kamran, Zeitzer Jamie M, Enriquez Cathleen M, Wilson Charles L, Behnke Eric J, Fried Itzhak, Engel Jerome
Regional analyses of CNS microdialysate glucose and lactate in seizure
patients
Epilepsia,
2002; 43(11):
1360-71.
Bragin Anatol, Wilson Charles L, Staba Richard J, Reddick Mark, Fried Itzhak, Engel Jerome
Interictal high-frequency oscillations (80-500 Hz) in the human
epileptic brain: entorhinal cortex
Annals of neurology,
2002; 52(4):
407-15.
Staba Richard J, Wilson Charles L, Bragin Anatol, Fried Itzhak, Engel Jerome
Quantitative analysis of high-frequency oscillations (80-500 Hz)
recorded in human epileptic hippocampus and entorhinal cortex
Journal of neurophysiology,
2002; 88(4):
1743-52.
Staba Richard J, Wilson Charles L, Bragin Anatol, Fried Itzhak, Engel Jerome
Sleep states differentiate single neuron activity recorded from human
epileptic hippocampus, entorhinal cortex, and subiculum
The Journal of neuroscience : the official journal of the Society for Neuroscience,
2002; 22(13):
5694-704.
Fried Itzhak, Cameron Katherine A, Yashar Sharona, Fong Raymond, Morrow Jack W
Inhibitory and excitatory responses of single neurons in the human
medial temporal lobe during recognition of faces and objects
Cerebral cortex (New York, N.Y. : 1991),
2002; 12(6):
575-84.
Staba Richard J, Wilson Charles L, Fried Itzhak, Engel Jerome
Single neuron burst firing in the human hippocampus during sleep
Hippocampus,
2002; 12(6):
724-34.