Itzhak Fried, M.D.

Director, Epilepsy Surgery

Professor, Neurosurgery

Psychiatry and Biobehavioral Sciences

Semel Institute for Neuroscience and Human Behavior

Member, Brain Research Institute

Neuroscience GPB Home Area

Biography

Professor of Neurosurgery and Psychiatry and Biobehavioral Sciences and Director of the Epilepsy Surgery Program. Dr. Itzhak Fried's research and clinical work is dedicated to the treatment of intractable seizure disorders and epilepsy and to the study of human memory from single neuron level to clinical intervention .

Suthana Nanthia, Fried Itzhak   Percepts to recollections: insights from single neuron recordings in the human brain Trends in cognitive sciences, 2012; .

Medvedovsky Mordekhay, Taulu Samu, Gaily Eija, Metsähonkala Eeva-Liisa, Mäkelä Jyrki P, Ekstein Dana, Kipervasser Svetlana, Neufeld Miri Y, Kramer Uri, Blomstedt Göran, Fried Itzhak, Karppinen Atte, Veshchev Igor, Roivainen Reina, Ben-Zeev Bruria, Goldberg-Stern Hadassah, Wilenius Juha, Paetau Ritva   Sensitivity and specificity of seizure-onset zone estimation by ictal magnetoencephalography Epilepsia, 2012; .

Engel Jerome, McDermott Michael P, Wiebe Samuel, Langfitt John T, Stern John M, Dewar Sandra, Sperling Michael R, Gardiner Irenita, Erba Giuseppe, Fried Itzhak, Jacobs Margaret, Vinters Harry V, Mintzer Scott, Kieburtz Karl, Kieburtz Karl   Early surgical therapy for drug-resistant temporal lobe epilepsy: a randomized trial JAMA : the journal of the American Medical Association, 2012; 307(9): 922-30.

Tankus Ariel, Fried Itzhak   Visuomotor coordination and motor representation by human temporal lobe neurons Journal of cognitive neuroscience, 2012; 24(3): 600-10.

Suthana Nanthia, Haneef Zulfi, Stern John, Mukamel Roy, Behnke Eric, Knowlton Barbara, Fried Itzhak   Memory enhancement and deep-brain stimulation of the entorhinal area The New England journal of medicine, 2012; 366(6): 502-10.

Staba Richard J, Ekstrom Arne D, Suthana Nanthia A, Burggren Alison, Fried Itzhak, Engel Jerome, Bookheimer Susan Y   Gray matter loss correlates with mesial temporal lobe neuronal hyperexcitability inside the human seizure-onset zone Epilepsia, 2012; 53(1): 25-34.

Mukamel Roy, Fried Itzhak   Human intracranial recordings and cognitive neuroscience Annual review of psychology, 2012; 63(6): 511-37.

Mukamel Roy, Nir Yuval, Harel Michal, Arieli Amos, Malach Rafael, Fried Itzhak   Invariance of firing rate and field potential dynamics to stimulus modulation rate in human auditory cortex Human brain mapping, 2011; 32(8): 1181-93.

Fried Itzhak, Mukamel Roy, Kreiman Gabriel   Internally generated preactivation of single neurons in human medial frontal cortex predicts volition Neuron, 2011; 69(3): 548-62.

Mukamel Roy, Ekstrom Arne D, Kaplan Jonas, Iacoboni Marco, Fried Itzhak   Single-neuron responses in humans during execution and observation of actions Current biology : CB, 2010; 20(8): 750-6.

Upchurch Kristen, Stern John M, Salamon Noriko, Dewar Sandra, Engel Jerome, Vinters Harry V, Fried Itzhak   Epileptogenic temporal cavernous malformations: operative strategies and postoperative seizure outcomes Seizure : the journal of the British Epilepsy Association, 2010; 19(2): 120-8.

Engel Jerome, Akhtari Massoud, Bragin Anatol, Fried Itzhak, Ogren Jennifer A, Staba Richard J, Salamon Noriko, Thompson Paul M   New approaches to structural and functional imaging in focal epilepsy Epilepsia, 2010; 51 Suppl 1(2): 83-6.

Viskontas Indre V, Quiroga Rodrigo Quian, Fried Itzhak   Human medial temporal lobe neurons respond preferentially to personally relevant images Proceedings of the National Academy of Sciences of the United States of America, 2009; 106(50): 21329-34.

Ogren Jennifer A, Wilson Charles L, Bragin Anatol, Lin Jack J, Salamon Noriko, Dutton Rebecca A, Luders Eileen, Fields Tony A, Fried Itzhak, Toga Arthur W, Thompson Paul M, Engel Jerome, Staba Richard J   Three-dimensional surface maps link local atrophy and fast ripples in human epileptic hippocampus Annals of neurology, 2009; 66(6): 783-91.

Tankus Ariel, Yeshurun Yehezkel, Fried Itzhak   An automatic measure for classifying clusters of suspected spikes into single cells versus multiunits Journal of neural engineering, 2009; 6(5): 056001.

Lerner Jason T, Salamon Noriko, Hauptman Jason S, Velasco Tonicarlo R, Hemb Marta, Wu Joyce Y, Sankar Raman, Donald Shields W, Engel Jerome, Fried Itzhak, Cepeda Carlos, Andre Veronique M, Levine Michael S, Miyata Hajime, Yong William H, Vinters Harry V, Mathern Gary W   Assessment and surgical outcomes for mild type I and severe type II cortical dysplasia: a critical review and the UCLA experience Epilepsia, 2009; 50(6): 1310-35.

Tankus Ariel, Yeshurun Yehezkel, Flash Tamar, Fried Itzhak   Encoding of speed and direction of movement in the human supplementary motor area Journal of neurosurgery, 2009; 110(6): 1304-16.

Ekstrom Arne, Suthana Nanthia, Behnke Eric, Salamon Noriko, Bookheimer Susan, Fried Itzhak   High-resolution depth electrode localization and imaging in patients with pharmacologically intractable epilepsy Journal of neurosurgery, 2008; 108(4): 812-5.

Staba Richard J, Frighetto Leonardo, Behnke Eric J, Mathern Gary W, Fields Tony, Bragin Anatol, Ogren Jennifer, Fried Itzhak, Wilson Charles L, Engel Jerome   Increased fast ripple to ripple ratios correlate with reduced hippocampal volumes and neuron loss in temporal lobe epilepsy patients Epilepsia, 2007; 48(11): 2130-8.

Viskontas Indre V, Ekstrom Arne D, Wilson Charles L, Fried Itzhak   Characterizing interneuron and pyramidal cells in the human medial temporal lobe in vivo using extracellular recordings Hippocampus, 2007; 17(1): 49-57.

Ekstrom Arne, Viskontas Indre, Kahana Michael, Jacobs Josh, Upchurch Kristen, Bookheimer Susan, Fried Itzhak   Contrasting roles of neural firing rate and local field potentials in human memory Hippocampus, 2007; 17(8): 606-17.

Viskontas Indre V, Knowlton Barbara J, Steinmetz Peter N, Fried Itzhak   Differences in mnemonic processing by neurons in the human hippocampus and parahippocampal regions Journal of cognitive neuroscience, 2006; 18(10): 1654-62.

Zeitzer Jamie M, Morales-Villagran Alberto, Maidment Nigel T, Behnke Eric J, Ackerson Larry C, Lopez-Rodriguez Faustino, Fried Itzhak, Engel Jerome, Wilson Charles L   Extracellular adenosine in the human brain during sleep and sleep deprivation: an in vivo microdialysis study Sleep, 2006; 29(4): 455-61.

Schrader Lara M, Stern John M, Wilson Charles L, Fields Tony A, Salamon Noriko, Nuwer Marc R, Vespa Paul M, Fried Itzhak   Low frequency electrical stimulation through subdural electrodes in a case of refractory status epilepticus Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2006; 117(4): 781-8.

Bragin Anatol, Wilson Charles L, Fields Tony, Fried Itzhak, Engel Jerome   Analysis of seizure onset on the basis of wideband EEG recordings Epilepsia, 2005; 46 Suppl 5(5736): 59-63.

Ekstrom Arne D, Caplan Jeremy B, Ho Emily, Shattuck Kirk, Fried Itzhak, Kahana Michael J   Human hippocampal theta activity during virtual navigation Hippocampus, 2005; 15(7): 881-9.

Frazee John, Fried Itzhak, Kawamoto Henry, Lazareff Jorge, Nieto Jaime, Patel Swati, Urata Mark, van de Wiele Barbara   The separation of Guatemalan craniopagus twins Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery, 2004; 20(8-9): 593-600.

Staba Richard J, Wilson Charles L, Bragin Anatol, Jhung Donald, Fried Itzhak, Engel Jerome   High-frequency oscillations recorded in human medial temporal lobe during sleep Annals of neurology, 2004; 56(1): 108-15.

Amador Nelly, Fried Itzhak   Single-neuron activity in the human supplementary motor area underlying preparation for action Journal of neurosurgery, 2004; 100(2): 250-9.

Cornford Eain M, Shamsa Kamran, Zeitzer Jamie M, Enriquez Cathleen M, Wilson Charles L, Behnke Eric J, Fried Itzhak, Engel Jerome   Regional analyses of CNS microdialysate glucose and lactate in seizure patients Epilepsia, 2002; 43(11): 1360-71.

Bragin Anatol, Wilson Charles L, Staba Richard J, Reddick Mark, Fried Itzhak, Engel Jerome   Interictal high-frequency oscillations (80-500 Hz) in the human epileptic brain: entorhinal cortex Annals of neurology, 2002; 52(4): 407-15.

Staba Richard J, Wilson Charles L, Bragin Anatol, Fried Itzhak, Engel Jerome   Quantitative analysis of high-frequency oscillations (80-500 Hz) recorded in human epileptic hippocampus and entorhinal cortex Journal of neurophysiology, 2002; 88(4): 1743-52.

Staba Richard J, Wilson Charles L, Bragin Anatol, Fried Itzhak, Engel Jerome   Sleep states differentiate single neuron activity recorded from human epileptic hippocampus, entorhinal cortex, and subiculum The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002; 22(13): 5694-704.

Fried Itzhak, Cameron Katherine A, Yashar Sharona, Fong Raymond, Morrow Jack W   Inhibitory and excitatory responses of single neurons in the human medial temporal lobe during recognition of faces and objects Cerebral cortex (New York, N.Y. : 1991), 2002; 12(6): 575-84.

Staba Richard J, Wilson Charles L, Fried Itzhak, Engel Jerome   Single neuron burst firing in the human hippocampus during sleep Hippocampus, 2002; 12(6): 724-34.