Hyong Jin Cho, M.D., Ph.D.


Associate Professor, Psychiatry and Biobehavioral Sciences

Contact Information

HJCho at mednet dot ucla dot edu
Work Phone Number: (310) 301-7396

Office Address:

Cousins Center for Psychoneuroimmunology
UCLA Semel Institute for Neuroscience and Human Behavior
300 Medical Plaza, Suite 3200A
Los Angeles, CA 90095


Joshua Hyong-Jin Cho, MD, PhD, MSc, FAPA, is Clinical Professor of Psychiatry in the Department of Psychiatry and Biobehavioral Sciences at UCLA and a board-certified psychiatrist. Dr. Cho's clinical activities are focused on the treatment of insomnia and depression.


His research has focused on the role of inflammation in depression, fatigue, and sleep disturbance, three constructs often collectively named as ‘sickness behavior’. He currently conducts epidemiological and translational studies pursuing clinical application of inflammation-related approaches. He obtained his medical degree at the University of Sao Paulo Medical School, and completed his psychiatry residency first at the University of Sao Paulo and later at UCLA. He obtained a master’s degree in epidemiology at the London School of Hygiene & Tropical Medicine, and completed a PhD program at the Institute of Psychiatry, King’s College London. He also trained as a postdoctoral fellow at the Cousins Center for Psychoneuroimmunology at UCLA. He is the recipient of the NIH R21 Exploratory/Developmental Research Grant Award, the NIH K23 Career Development Award, the UCLA CTSI KL2 Translational Science Award, the NARSAD Young Investigator Grant, and several other awards from institutions such as National Institutes of Health (NIH), American Psychiatric Association, Southern Psychiatric Association, American Psychosomatic Society, Korean Neuro-Psychiatric Association, Friends of the Semel Institute, and Claude D. Pepper Older Americans Independence Center. His prolific scientific work has been published in prestigious journals including American Journal of Psychiatry, Molecular Psychiatry, Biological Psychiatry, and British Journal of Psychiatry.


View a up-to-date publication list: https://www.ncbi.nlm.nih.gov/myncbi/joshua.cho.1/bibliography/public/

A selected list of publications:

Cho Joshua Hyong-Jin, Olmstead Richard, Choi Hanbyul, Carrillo Carmen, Seeman Teresa E, Irwin Michael R   Associations of objective versus subjective social isolation with sleep disturbance, depression, and fatigue in community-dwelling older adults Aging & mental health, 2018; 1-9.
Irwin Michael R, Cole Steve, Olmstead Richard, Breen Elizabeth C, Cho Joshua Jin, Moieni Mona, Eisenberger Naomi I   Moderators for depressed mood and systemic and transcriptional inflammatory responses: a randomized controlled trial of endotoxin Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018; e13465.
Diniz-Filho Alberto, Abe Ricardo Y, Cho Hyong Jin, Baig Saif, Gracitelli Carolina P B, Medeiros Felipe A   Reply Ophthalmology, 2017; 124(2): e21.
Cho Hyong Jin, Savitz Jonathan, Dantzer Robert, Teague T Kent, Drevets Wayne C, Irwin Michael R   Sleep disturbance and kynurenine metabolism in depression Journal of psychosomatic research, 2017; 99: 1-7.
Diniz-Filho Alberto, Abe Ricardo Y, Cho Hyong Jin, Baig Saif, Gracitelli Carolina P B, Medeiros Felipe A   Fast Visual Field Progression Is Associated with Depressive Symptoms in Patients with Glaucoma Ophthalmology, 2016; .
Cho HJ, Eisenberger NI, Olmstead R, Breen EC, Irwin MR   Preexisting mild sleep disturbance as a vulnerability factor for inflammation-induced depressed mood: a human experimental study Translational Psychiatry, 2016; 6(3): e750.
Choi Hanbyul, Irwin Michael R, Cho Hyong Jin   Impact of social isolation on behavioral health in elderly: Systematic review World journal of psychiatry, 2015; 5(4): 432-8.
Cho Hyong Jin, Irwin Michael R   Is Inflammation a Link Between Self-Reported Health and Infectious Disease Risk? Psychosomatic medicine, 2015; 77(9): 956-8.
Cho Hyong Jin   Is Sleep Health a Potential Pathway to Global Mental Health? Sleep, 2015; 38(12): 1837-8.
Brunoni Andre R, Machado-Vieira Rodrigo, Sampaio-Junior Bernardo, Vieira Erica L M, Valiengo Leandro, Benseñor Isabela M, Lotufo Paulo A, Carvalho Andre F, Cho Hyong Jin, Gattaz Wagner F, Teixeira Antonio L   Plasma levels of soluble TNF receptors 1 and 2 after tDCS and sertraline treatment in major depression: Results from the SELECT-TDCS trial Journal of affective disorders, 2015; 185(9): 209-13.
Cho Hyong Jin, Seeman Teresa E, Kiefe Catarina I, Lauderdale Diane S, Irwin Michael R   Sleep Disturbance and Longitudinal Risk of Inflammation: Moderating Influences of Social Integration and Social Isolation in the Coronary Artery Risk Development in Young Adults (CARDIA) Study Brain, behavior, and immunity, 2015; .
Moieni Mona, Irwin Michael R, Jevtic Ivana, Breen Elizabeth C, Cho Hyong Jin, Arevalo Jesusa M G, Ma Jeffrey, Cole Steven W, Eisenberger Naomi I   Trait sensitivity to social disconnection enhances pro-inflammatory responses to a randomized controlled trial of endotoxin Psychoneuroendocrinology, 2015; 62(4): 336-42.
Cho, H. J. Kivimaeki, M. Bower, J. E. Irwin, M. R.   Association of C-reactive protein and interleukin-6 with new-onset fatigue in the Whitehall II prospective cohort study Psychological Medicine, 2013; 43(8): 1773-1783.
Lee Eun, Cho Hyong Jin, Olmstead Richard, Levin Myron J, Oxman Michael N, Irwin Michael R   Persistent sleep disturbance: a risk factor for recurrent depression in community-dwelling older adults Sleep, 2013; 36(11): 1685-91.
Cho Hyong Jin, Bower Julienne E, Kiefe Catarina I, Seeman Teresa E, Irwin Michael R   Early life stress and inflammatory mechanisms of fatigue in the Coronary Artery Risk Development in Young Adults (CARDIA) study Brain, behavior, and immunity, 2012; 26(6): 859-65.
Ishii Shinya, Karlamangla Arun S, Bote Marcos, Irwin Michael R, Jacobs David R, Cho Hyong Jin, Seeman Teresa E   Gender, obesity and repeated elevation of C-reactive protein: data from the CARDIA cohort PloS one, 2012; 7(4): e36062.
Kang Jee In, Kim Se Joo, Cho Hyong Jin, Jhung Kyungun, Lee Su Young, Lee Eun, An Suk Kyoon   Psychometric analysis of the Korean version of the Disgust Scale-Revised Comprehensive psychiatry, 2012; 53(5): 648-55.
Cho Hyong Jin, Lavretsky Helen, Olmstead Richard, Levin Myron, Oxman Michael N, Irwin Michael R   Prior depression history and deterioration of physical health in community-dwelling older adults--a prospective cohort study The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry, 2010; 18(5): 442-51.
Cho Hyong Jin, Menezes Paulo Rossi, Hotopf Matthew, Bhugra Dinesh, Wessely Simon   Comparative epidemiology of chronic fatigue syndrome in Brazilian and British primary care: prevalence and recognition The British journal of psychiatry : the journal of mental science, 2009; 194(2): 117-22.
Cho Hyong Jin, Seeman Teresa E, Bower Julienne E, Kiefe Catarina I, Irwin Michael R   Prospective association between C-reactive protein and fatigue in the coronary artery risk development in young adults study Biological psychiatry, 2009; 66(9): 871-8.
O'Connor Mary-Frances, Bower Julie E, Cho Hyong Jin, Creswell J David, Dimitrov Stoyan, Hamby Mary E, Hoyt Michael A, Martin Jennifer L, Robles Theodore F, Sloan Erica K, Thomas Kamala S, Irwin Michael R   To assess, to control, to exclude: effects of biobehavioral factors on circulating inflammatory markers Brain, behavior, and immunity, 2009; 23(7): 887-97.
Cho Hyong Jin, Lavretsky Helen, Olmstead Richard, Levin Myron J, Oxman Michael N, Irwin Michael R   Sleep disturbance and depression recurrence in community-dwelling older adults: a prospective study The American journal of psychiatry, 2008; 165(12): 1543-50.
Irwin Michael R, Wang Minge, Ribeiro Denise, Cho Hyong Jin, Olmstead Richard, Breen Elizabeth Crabb, Martinez-Maza Otoniel, Cole Steve   Sleep loss activates cellular inflammatory signaling Biological psychiatry, 2008; 64(6): 538-40.
Cho Hyong Jin, Menezes Paulo Rossi, Bhugra Dinesh, Wessely Simon   The awareness of chronic fatigue syndrome: a comparative study in Brazil and the United Kingdom Journal of psychosomatic research, 2008; 64(4): 351-5.
Cho Hyong Jin, Costa Erico, Menezes Paulo Rossi, Chalder Trudie, Bhugra Dinesh, Wessely Simon   Cross-cultural validation of the Chalder Fatigue Questionnaire in Brazilian primary care Journal of psychosomatic research, 2007; 62(3): 301-4.
Cho, Hyong Jin; Wessely, Simon   The prevalence and associations of unexplained chronic fatigue in Brazilian primary care, Primary Care & Community Psychiatry, 2007; 12(2): 81-87.
Cho Hyong Jin, Skowera Anna, Cleare Anthony, Wessely Simon   Chronic fatigue syndrome: an update focusing on phenomenology and pathophysiology Current opinion in psychiatry, 2006; 19(1): 67-73.
Meira-Lima Ivanor, Michelon Leandro, Cordeiro Quirino, Cho Hyong Jin, Vallada Homero   Allelic association analysis of the functional insertion/deletion polymorphism in the promoter region of the serotonin transporter gene in bipolar affective disorder Journal of molecular neuroscience : MN, 2005; 27(2): 219-24.
Cho Hyong Jin, Wessely Simon   Chronic fatigue syndrome: an overview Revista brasileira de psiquiatria (São Paulo, Brazil : 1999), 2005; 27(3): 174-5.
Cho, H. J. Meira-Lima, I. Cordeiro, Q. Michelon, L. Sham, P. Vallada, H. Collier, D. A.   Population-based and family-based studies on the serotonin transporter gene polymorphisms and bipolar disorder: a systematic review and meta-analysis Molecular Psychiatry, 2005; 10(8): 771-781.
Cho Hyong Jin   Reviving the old sermon of medicine with the placebo effect Revista brasileira de psiquiatria, 2005; 27(4): 336-40.
Cho Hyong Jin, Hotopf Matthew, Wessely Simon   The placebo response in the treatment of chronic fatigue syndrome: a systematic review and meta-analysis Psychosomatic medicine, 2005; 67(2): 301-13.
De Souza, MDM; Messing, K; Menezes, PR; Cho, HJ   Chronic fatigue among bank workers in Brazil, Occupational Medicine-Oxford, 2002; 52(4): 187-194.
Kruse Jennifer L, Cho Joshua Hyong-Jin, Olmstead Richard, Hwang Lin, Faull Kym, Eisenberger Naomi I, Irwin Michael R   Kynurenine metabolism and inflammation-induced depressed mood: A human experimental study Psychoneuroendocrinology, 2019; 109: 104371.
Piber Dominique, Olmstead Richard, Cho Joshua Hyong-Jin, Witarama Tuff, Perez Christian, Dietz Nicholas, Seeman Teresa E, Breen Elizabeth C, Cole Steve W, Irwin Michael R   Inflammaging: Age and Systemic, Cellular, and Nuclear Inflammatory Biology in Older Adults The journals of gerontology. Series A, Biological sciences and medical sciences, 2019; 109: 104371.
Cho Joshua Hyong-Jin, Irwin Michael R, Eisenberger Naomi I, Lamkin Donald M, Cole Steve W   Transcriptomic predictors of inflammation-induced depressed mood Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2019; 44(5): 923-929.
Piber Dominique, Eisenberger Naomi I, Olmstead Richard, Cho Joshua H, Breen Elizabeth C, Boyle Chloe C, Karmarkar Ellora, Guzman Miguel, Kim Haesoo, Irwin Michael R   Sleep, inflammation, and perception of sad facial emotion: A laboratory-based study in older adults Brain, behavior, and immunity, 2020; 89(11): 159-167.
Cho Joshua H, Bhutani Saumya, Kim Carole H, Irwin Michael R   Anti-inflammatory effects of melatonin: A systematic review and meta-analysis of clinical trials Brain, behavior, and immunity, 2021; 93(3): 245-253.
Cho Joshua Hyong-Jin, Shu Sara M, Mahbod Ariya, Irwin Michael R   Lipopolysaccharide-stimulated intracellular cytokines and depressive symptoms in community-dwelling older adults Revista de psiquiatria clinica, 2019; 46(5): 137-140.
Boyle Chloe C, Cho Joshua H, Eisenberger Naomi I, Olmstead Richard E, Piber Dominique, Sadeghi Nina, Tazhibi Masih, Irwin Michael R   Motivation and sensitivity to monetary reward in late-life insomnia: moderating role of sex and the inflammatory marker CRP Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2020; 45(10): 1664-1671.
Cho Joshua H, Kremer Stephanie, Young Jeffrey   Who to Refer to a Behavioral Insomnia Clinic? - Recommendations Based on Treatment Rationale and Response Prediction Current sleep medicine reports, 2021; 7(4): 213-220.
Punjabi Naresh M, Brown Todd, Aurora R Nisha, Patel Sanjay R, Stosor Valentina, Cho Joshua Hyong-Jin, Helgadóttir Halla, Ágústsson Jón Skírnir, D'Souza Gypsyamber, Margolick Joseph B   Methods for home-based self-applied polysomnography: the Multicenter AIDS Cohort Study Sleep advances : a journal of the Sleep Research Society, 2022; 3(1): zpac011.
Piber Dominique, Olmstead Richard, Cho Joshua H, Guzman Miguel, Irwin Michael R   Interferon- Psychological medicine, 2022; 3(1): 1-9.