Gerald Lipshutz


Professor In-Residence, Surgery

Endocrinology, Diabetes and Hypertension

Molecular & Medical Pharmacology

Member, Liver Transplantation


Molecular Pharmacology GPB Home Area

Pfleger Liver Institute

Tumor Immunology Program at the Jonsson Comprehensive Cancer Center (JCCC)

Contact Information

Fax Number: 310-267-3590
Work Phone Number: (310) 267-9592

Mailing Address:

650 CE Young Drive
Box 957054
UCLA School of Medicine
Los Angeles, CA 90095
BOX 957054
635 Charles E. Young Drive South
Los Angeles, CA 90095


The Lipshutz Lab focuses on regenerative medicine technologies for the investigation and treatment of urea cycle disorders.


Please go to to learn more about the lab.


A selected list of publications:

Khoja Suhail, Nitzahn Matt, Hermann Kip, Truong Brian, Borzone Roberta, Willis Brandon, Rudd Mitchell, Palmer Donna J, Ng Philip, Brunetti-Pierri Nicola, Lipshutz Gerald S   Conditional disruption of hepatic carbamoyl phosphate synthetase 1 in mice results in hyperammonemia without orotic aciduria and can be corrected by liver-directed gene therapy Molecular genetics and metabolism, 2018; 124(4): 243-253.
Salas Jessica R, Chen Bao Ying, Wong Alicia, Duarte Sergio, Angarita Stephanie A K, Lipshutz Gerald S, Witte Owen N, Clark Peter M   Noninvasive Imaging of Drug-Induced Liver Injury with Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2018; 59(8): 1308-1315.
Koo Matthew, Lipshutz Gerald S, Cederbaum Stephen D, Lassman Charles   Biopsy-proven Hepatocellular Carcinoma in a 53-year-old Woman With Arginase Deficiency Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, 2018; 20(6): 517-521.
Mavila Nirmala, Trecartin Andrew, Spurrier Ryan, Xiao Yi, Hou Xiaogang, James David, Fu Xiaowei, Truong Brian, Wang Clara, Lipshutz Gerald S, Wang Kasper S, Grikscheit Tracy C   Functional Human and Murine Tissue-Engineered Liver Is Generated from Adult Stem/Progenitor Cells Stem cells translational medicine, 2017; 6(1): 238-248.
Lee Patrick C, Truong Brian, Vega-Crespo Agustin, Gilmore W Blake, Hermann Kip, Angarita Stephanie Ak, Tang Jonathan K, Chang Katherine M, Wininger Austin E, Lam Alex K, Schoenberg Benjamen E, Cederbaum Stephen D, Pyle April D, Byrne James A, Lipshutz Gerald S   Restoring Ureagenesis in Hepatocytes by CRISPR/Cas9-mediated Genomic Addition to Arginase-deficient Induced Pluripotent Stem Cells Molecular therapy. Nucleic acids, 2016; 5(11): e394.
Cantero Gloria, Liu Xiao-Bo, Mervis Ronald F, Lazaro Maria T, Cederbaum Stephen D, Golshani Peyman, Lipshutz Gerald S   Rescue of the Functional Alterations of Motor Cortical Circuits in Arginase Deficiency by Neonatal Gene Therapy The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016; 36(25): 6680-90.
Liu Yang, Du Juanjuan, Choi Jin-sil, Chen Kuan-Ju, Hou Shuang, Yan Ming, Lin Wei-Yu, Chen Kevin Sean, Ro Tracy, Lipshutz Gerald S, Wu Lily, Shi Linqi, Lu Yunfeng, Tseng Hsian-Rong, Wang Hao   A High-Throughput Platform for Formulating and Screening Multifunctional Nanoparticles Capable of Simultaneous Delivery of Genes and Transcription Factors Angewandte Chemie (International ed. in English), 2016; 55(1): 169-73.
Hu Chuhong, Kasten Jennifer, Park Hana, Bhargava Ragini, Tai Denise S, Grody Wayne W, Nguyen Quynh G, Hauschka Stephen D, Cederbaum Stephen D, Lipshutz Gerald S   Myocyte-mediated arginase expression controls hyperargininemia but not hyperammonemia in arginase-deficient mice Molecular therapy : the journal of the American Society of Gene Therapy, 2014; 22(10): 1792-802.
Kasten Jennifer, Hu Chuhong, Bhargava Ragini, Park Hana, Tai Denise, Byrne James A, Marescau Bart, De Deyn Peter P, Schlichting Lisa, Grody Wayne W, Cederbaum Stephen D, Lipshutz Gerald S   Lethal phenotype in conditional late-onset arginase 1 deficiency in the mouse Molecular genetics and metabolism, 2013; 110(3): 222-30.
Awe Jason P, Lee Patrick C, Ramathal Cyril, Vega-Crespo Agustin, Durruthy-Durruthy Jens, Cooper Aaron, Karumbayaram Saravanan, Lowry William E, Clark Amander T, Zack Jerome A, Sebastiano Vittorio, Kohn Donald B, Pyle April D, Martin Martin G, Lipshutz Gerald S, Phelps Patricia E, Pera Renee A Reijo, Byrne James A   Generation and characterization of transgene-free human induced pluripotent stem cells and conversion to putative clinical-grade status Stem cell research & therapy, 2013; 4(4): 87.
Lee Eun K, Hu Chuhong, Bhargava Ragini, Rozengurt Nora, Stout David, Grody Wayne W, Cederbaum Stephen D, Lipshutz Gerald S   Long-term survival of the juvenile lethal arginase-deficient mouse with AAV gene therapy Molecular therapy : the journal of the American Society of Gene Therapy, 2012; 20(10): 1844-51.
Hu Chuhong, Cela Racel G, Suzuki Masataka, Lee Brendan, Lipshutz Gerald S   Neonatal helper-dependent adenoviral vector gene therapy mediates correction of hemophilia A and tolerance to human factor VIII Proceedings of the National Academy of Sciences of the United States of America, 2011; 108(5): 2082-7.
Hu Chuhong, Busuttil Ronald W, Lipshutz Gerald S   RH10 provides superior transgene expression in mice when compared with natural AAV serotypes for neonatal gene therapy The journal of gene medicine, 2010; 12(9): 766-78.
Gau Chia-Ling, Rosenblatt Robin A, Cerullo Vincenzo, Lay Fides D, Dow Adrienne C, Livesay Justin, Brunetti-Pierri Nicola, Lee Brendan, Cederbaum Stephen D, Grody Wayne W, Lipshutz Gerald S   Short-term correction of arginase deficiency in a neonatal murine model with a helper-dependent adenoviral vector Molecular therapy : the journal of the American Society of Gene Therapy, 2009; 17(7): 1155-63.
Nguyen Andrew T, Dow Adrienne C, Kupiec-Weglinski Jerzy, Busuttil Ronald W, Lipshutz Gerald S   Evaluation of gene promoters for liver expression by hydrodynamic gene transfer The Journal of surgical research, 2008; 148(1): 60-6.
Ke Bibo, Lipshutz Gerald S, Kupiec-Weglinski Jerzy W   Gene therapy in liver ischemia and reperfusion injury Current pharmaceutical design, 2006; 12(23): 2969-75.
Lipshutz Gerald S, Titre Deborah, Brindle Mary, Bisconte Angelina R, Contag Christopher H, Gaensler Karin M L   Comparison of gene expression after intraperitoneal delivery of AAV2 or AAV5 in utero Molecular therapy : the journal of the American Society of Gene Therapy, 2003; 8(1): 90-8.