Bruce Kagan, M.D.

Director, Adult Partial Hospitalization Program

Professor, Psychiatry and Biobehavioral Sciences

Member, Adult Psychiatry

Brain Research Institute

Neuroscience GPB Home Area

Biography

Bruce L. Kagan is a psychiatrist and neurophysiologist who joined the UCLA faculty in 1986. He became a full professor in 1998 and served as Director of the Psychiatry Research Residency Track from 1994-2004. He has chaired the Medical Institutional Review Board for Neuropsychiatry since 2004. He is currently Chief of Staff of the Resnick Neuropsychiatric Hospital. Dr. Kagan earned his BA cum laude in Molecular Biophysics and Biochemistry from Yale University. He received the MD and Ph.D. (physiology) degrees from the Albert Einstein College of Medicine. His laboratory research centers on channel forming toxins. He is currently studying channels formed by amyloid peptides in Alzheimer's and Parkinson's disease to elucidate the pathogenesis of these illnesses. He is also screening chemical libraries for channel blockers that could be used as therapeutic agents.

Kagan Bruce L, Jang Hyunbum, Capone Ricardo, Teran Arce Fernando, Ramachandran Srinivasan, Lal Ratnesh, Nussinov Ruth   Antimicrobial properties of amyloid peptides Molecular pharmaceutics, 2012; 9(4): 708-17.

Connelly Laura, Jang Hyunbum, Arce Fernando Teran, Ramachandran Srinivasan, Kagan Bruce L, Nussinov Ruth, Lal Ratnesh   Effects of point substitutions on the structure of toxic Alzheimer's β-amyloid channels: atomic force microscopy and molecular dynamics simulations Biochemistry, 2012; 51(14): 3031-8.

Capone Ricardo, Jang Hyunbum, Kotler Samuel A, Connelly Laura, Teran Arce Fernando, Ramachandran Srinivasan, Kagan Bruce L, Nussinov Ruth, Lal Ratnesh   All-d-Enantiomer of β-Amyloid Peptide Forms Ion Channels in Lipid Bilayers Journal of chemical theory and computation, 2012; 8(3): 1143-1152.

Connelly Laura, Jang Hyunbum, Arce Fernando Teran, Capone Ricardo, Kotler Samuel A, Ramachandran Srinivasan, Kagan Bruce L, Nussinov Ruth, Lal Ratnesh   Atomic force microscopy and MD simulations reveal pore-like structures of all-D-enantiomer of Alzheimer's β-amyloid peptide: relevance to the ion channel mechanism of AD pathology The journal of physical chemistry. B, 2012; 116(5): 1728-35.

Kagan Bruce L   Membrane pores in the pathogenesis of neurodegenerative disease Progress in molecular biology and translational science, 2012; 107(3): 295-325.

Capone Ricardo, Jang Hyunbum, Kotler Samuel A, Kagan Bruce L, Nussinov Ruth, Lal Ratnesh   Probing structural features of Alzheimer's amyloid-β pores in bilayers using site-specific amino acid substitutions Biochemistry, 2012; 51(3): 776-85.

Kagan Bruce L   Antimicrobial amyloids? Biophysical journal, 2011; 100(7): 1597-8.

Kagan Bruce L, Thundimadathil Jyothi   Amyloid peptide pores and the beta sheet conformation Advances in experimental medicine and biology, 2010; 677(14): 150-67.

Jang Hyunbum, Arce Fernando Teran, Ramachandran Srinivasan, Capone Ricardo, Azimova Rushana, Kagan Bruce L, Nussinov Ruth, Lal Ratnesh   Truncated beta-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(14): 6538-43.

Quist, A., Doudevski, I., Lin, H., Azimova, R., Ng, D., Frangione, B., Kagan, B., Ghiso, J., Lal, R.   Amyloid ion channels: A common structural link for protein-misfolding disease, Proc Natl Acad Sci USA, 2005; 102(30): 10427-32.

Kagan, B.L.   Amyloidosis and protein folding, Science, 2005; 307: 42-3.

Kagan Bruce L   Amyloidosis and protein folding Science (New York, N.Y.), 2005; 307(5706): 42-3; author reply 42-3.

Kagan, B.L., Azimova, R., Azimov, R.   Amyloid peptide channels, J Memb Biol, 2004; 202: 1-10.

Lin Meng-chin Allison, Kagan Bruce L   Electrophysiologic properties of channels induced by Abeta25-35 in planar lipid bilayers Peptides, 2002; 23(7): 1215-28.

Kagan, BL Hirakura, Y Azimov, R Azimova, R Lin, MC   The channel hypothesis of Alzheimer's disease: current status Peptides. , 2002; 23(7): 1311-5.

Kagan Bruce L, Hirakura Yutaka, Azimov Rustam, Azimova Rushana, Lin Meng-Chin   The channel hypothesis of Alzheimer's disease: current status Peptides, 2002; 23(7): 1311-5.

Lin, M-C., Mirzabekov, T., Kagan, B.L.   Electrophysiologic Properties of Alpha Beta 25-35 channels, Peptides, 2002; 23(7): 1215-28.

Hirakura, Y., Lin, M-C., Kagan, B.L.   The Channel hypothesis of Alzheimer's disease: current status, Peptides, 2002; 23(7): 1311-5.

Hirakura, Y., Kagan, B.L.   The channel hypothesis of amyloidosis, Cellular and Molecular Mechanics of Toxin Action, 2002; Vol. 5, (in press): .

Hirakura Yutaka, Carreras Isabel, Sipe Jean D, Kagan Bruce L   Channel formation by serum amyloid A: a potential mechanism for amyloid pathogenesis and host defense Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, 2002; 9(1): 13-23.

Kagan, BL Hirakura, Y Azimov, R Azimova, R   The channel hypothesis of Huntington's disease Brain research bulletin. , 2001; 56(3-4): 281-4.

Hirakura, Y Kagan, BL   Pore formation by beta-2-microglobulin: a mechanism for the pathogenesis of dialysis associated amyloidosis Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. , 2001; 8(2): 94-100.