Anthony Campagnoni, Ph.D.

Associate Director, Psychiatry and Biobehavioral Sciences

Member, Basic/Translational Research, Jonsson Comprehensive Cancer Center

Emeritus Member, Brain Research Institute

Professor Emeritus, Psychiatry and Biobehavioral Sciences

Semel Institute for Neuroscience and Human Behavior

Biography

Molecular and cellular mechanisms regulating neuronal and glial cell function in the central nervous system Dr. Campagnoni's research covers three areas: 1. Exploring the roles of a novel Myelin Basic Protein sequence-containing gene in neural development in process extension and migration. In the past year Campagnoni and colleagues have continued their studies on a novel gene, which they call the Golli gene, that overlaps and includes the myelin basic protein gene. Campagnoni's team have been actively pursuing the function of the protein products of this gene. Campagnoni's laboratory have completed an extensive series of studies to determine where and when the protein products are expressed, and have found that they are expressed in neurons and in oligodendrocytes in mice and in humans. Golli proteins are expressed in pioneering neurons in the developing nervous system and Campagnoni believes that they are involved in process extension and neuronal migration early in development. Campagnoni and colleagues have produced several "immortalized" mouse cell lines in which these Golli proteins are synthesized and they appear to be associated with the cytoskeleton. Under certain conditions, in vivo and in vitro, the Golli proteins are found to be transported into the nuclei of some neurons, where Campagnoni believes they have a second role, possibly in regulating gene expression. 2. Autoimmune implications of a Myelin Basic Protein sequence-containing gene expression in the thymus, spleen, and lymph nodes. Studies on the expression of the Golli products have opened up a new research area for the laboratory. Campagnoni's team find that Golli proteins (which contain myelin basic protein sequences) are expressed in the thymus, spleen and lymph nodes of the immune system. This prompted them to search for the expression of other myelin protein antigens in these immune tissues and have found that the myelin proteolipid proteins are also expressed in human t

Paez Pablo M, Cheli Veronica T, Ghiani Cristina A, Spreuer Vilma, Handley Vance W, Campagnoni Anthony T   Golli myelin basic proteins stimulate oligodendrocyte progenitor cell proliferation and differentiation in remyelinating adult mouse brain Glia, 2012; 60(7): 1078-93.

Smith Graham S T, Paez Pablo M, Spreuer Vilma, Campagnoni Celia W, Boggs Joan M, Campagnoni Anthony T, Harauz George   Classical 18.5-and 21.5-kDa isoforms of myelin basic protein inhibit calcium influx into oligodendroglial cells, in contrast to golli isoforms Journal of neuroscience research, 2011; 89(4): 467-80.

Paez Pablo M, Fulton Daniel, Spreuer Vilma, Handley Vance, Campagnoni Anthony T   Modulation of canonical transient receptor potential channel 1 in the proliferation of oligodendrocyte precursor cells by the golli products of the myelin basic protein gene The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011; 31(10): 3625-37.

Smith Graham S T, Paez Pablo M, Spreuer Vilma, Campagnoni Celia W, Boggs Joan M, Campagnoni Anthony T, Harauz George   Classical 18.5-and 21.5-kDa isoforms of myelin basic protein inhibit calcium influx into oligodendroglial cells, in contrast to golli isoforms Journal of neuroscience research, 2011; 31(10): .

Fulton Daniel, Paez Pablo, Spreur Vilma, Handley Vance, Colwell Christopher S, Campagnoni Anthony, Fisher Robin   Developmental activation of the proteolipid protein promoter transgene in neuronal and oligodendroglial cells of neostriatum in mice Developmental neuroscience, 2011; 33(2): 170-84.

Abad Catalina, Tan Yossan-Var, Lopez Robert, Nobuta Hiroko, Dong Hongmei, Phan Phu, Feng Ji-Ming, Campagnoni Anthony T, Waschek James A   Vasoactive intestinal peptide loss leads to impaired CNS parenchymal T-cell infiltration and resistance to experimental autoimmune encephalomyelitis Proceedings of the National Academy of Sciences of the United States of America, 2010; 107(45): 19555-60.

Magnani Dario, Hasenpusch-Theil Kerstin, Jacobs Erin C, Campagnoni Anthony T, Price David J, Theil Thomas   The Gli3 hypomorphic mutation Pdn causes selective impairment in the growth, patterning, and axon guidance capability of the lateral ganglionic eminence The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010; 30(41): 13883-94.

Fulton Daniel, Paez Pablo M, Fisher Robin, Handley Vance, Colwell Christopher S, Campagnoni Anthony T   Regulation of L-type Ca++ currents and process morphology in white matter oligodendrocyte precursor cells by golli-myelin proteins Glia, 2010; 58(11): 1292-303.

Paez Pablo M, Fulton Daniel J, Spreur Vilma, Handley Vance, Campagnoni Anthony T   Multiple kinase pathways regulate voltage-dependent Ca2+ influx and migration in oligodendrocyte precursor cells The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010; 30(18): 6422-33.

Fulton Daniel, Paez Pablo M, Campagnoni Anthony T   The multiple roles of myelin protein genes during the development of the oligodendrocyte ASN neuro, 2010; 2(1): e00027.

Piñon Maria Carmen, Jethwa Ankeet, Jacobs Erin, Campagnoni Anthony, Molnár Zoltán   Dynamic integration of subplate neurons into the cortical barrel field circuitry during postnatal development in the Golli-tau-eGFP (GTE) mouse The Journal of physiology, 2009; 587(Pt 9): 1903-15.

Paez Pablo M, Fulton Daniel J, Spreuer Vilma, Handley Vance, Campagnoni Celia W, Macklin Wendy B, Colwell Christopher, Campagnoni Anthony T   Golli myelin basic proteins regulate oligodendroglial progenitor cell migration through voltage-gated Ca2+ influx The Journal of neuroscience : the official journal of the Society for Neuroscience, 2009; 29(20): 6663-76.

Paez Pablo M, Fulton Daniel J, Spreuer Vilma, Handley Vance, Campagnoni Celia W, Campagnoni Anthony T   Regulation of store-operated and voltage-operated Ca2+ channels in the proliferation and death of oligodendrocyte precursor cells by golli proteins ASN neuro, 2009; 1(1): .

Jacobs Erin C, Reyes Samuel D, Campagnoni Celia W, Irene Givogri M, Kampf Kathy, Handley Vance, Spreuer Vilma, Fisher Robin, Macklin Wendy, Campagnoni Anthony T   Targeted overexpression of a golli-myelin basic protein isoform to oligodendrocytes results in aberrant oligodendrocyte maturation and myelination ASN neuro, 2009; 1(4): .

Paez Pablo M, Spreuer Vilma, Handley Vance, Feng Ji-Ming, Campagnoni Celia, Campagnoni Anthony T   Increased expression of golli myelin basic proteins enhances calcium influx into oligodendroglial cells The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007; 27(46): 12690-9.

Martin Melanie, Reyes Samuel D, Hiltner Timothy D, Givogri M Irene, Tyszka J Michael, Fisher Robin, Campagnoni Anthony T, Fraser Scott E, Jacobs Russell E, Readhead Carol   T(2)-weighted microMRI and evoked potential of the visual system measurements during the development of hypomyelinated transgenic mice Neurochemical research, 2007; 32(2): 159-65.

Molnár Zoltán, Hoerder-Suabedissen Anna, Wang Wei Zhi, DeProto Jamin, Davies Kay, Lee Sheena, Jacobs Erin C, Campagnoni Anthony T, Paulsen Ole, Piñon Maria Carmen, Cheung Amanda F P   Genes involved in the formation of the earliest cortical circuits Novartis Foundation symposium, 2007; 288(1): 212-24; discussion 224-9, 276-81.

Jacobs Erin C, Campagnoni Celia, Kampf Kathy, Reyes Samuel D, Kalra Vikram, Handley Vance, Xie Yuan-Yun, Hong-Hu Yan, Spreur Vilma, Fisher Robin S, Campagnoni Anthony T   Visualization of corticofugal projections during early cortical development in a tau-GFP-transgenic mouse The European journal of neuroscience, 2007; 25(1): 17-30.

Feng Ji-Ming, Hu Yanhong K, Xie Lai-Hua, Colwell Christopher S, Shao Xuesi M, Sun Xiao-Ping, Chen Boming, Tang Hezhen, Campagnoni Anthony T   Golli protein negatively regulates store depletion-induced calcium influx in T cells Immunity, 2006; 24(6): 717-27.

Paez Pablo M, García Corina I, Campagnoni Anthony T, Soto Eduardo F, Pasquini Juana M   Overexpression of human transferrin in two oligodendroglial cell lines enhances their differentiation Glia, 2005; 52(1): 1-15.

Jacobs Erin C, Pribyl Thomas M, Feng Ji-Ming, Kampf Kathy, Spreur Vilma, Campagnoni Celia, Colwell Christopher S, Reyes Samuel D, Martin Melanie, Handley Vance, Hiltner Timothy D, Readhead Carol, Jacobs Russell E, Messing Albee, Fisher Robin S, Campagnoni Anthony T   Region-specific myelin pathology in mice lacking the golli products of the myelin basic protein gene The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005; 25(30): 7004-13.

Feng Ji-Ming, Fernandes Augustine O, Campagnoni Celia W, Hu Yan-Hong, Campagnoni Anthony T   The golli-myelin basic protein negatively regulates signal transduction in T lymphocytes Journal of neuroimmunology, 2004; 152(1-2): 57-66.

Jacobs Erin C, Bongarzone Ernesto R, Campagnoni Celia W, Campagnoni Anthony T   Embryonic expression of the soma-restricted products of the myelin proteolipid gene in motor neurons and muscle Neurochemical research, 2004; 29(5): 997-1002.

Paez Pablo M, García Corina I, Davio Carlos, Campagnoni Anthony T, Soto Eduardo F, Pasquini Juana M   Apotransferrin promotes the differentiation of two oligodendroglial cell lines Glia, 2004; 46(2): 207-17.

Fernandes Augustine O, Campagnoni Celia W, Kampf Kathy, Feng Ji-Ming, Handley Vance W, Schonmann Vilma, Bongarzone Ernesto R, Reyes Sam, Campagnoni Anthony T   Identification of a protein that interacts with the golli-myelin basic protein and with nuclear LIM interactor in the nervous system Journal of neuroscience research, 2004; 75(4): 461-71.

Feng Ji-Ming, Fernandes Augustine O, Bongarzone Ernesto R, Campagnoni Celia W, Kampf Kathy, Campagnoni Anthony T   Expression of soma-restricted proteolipid/DM20 proteins in lymphoid cells Journal of neuroimmunology, 2003; 144(1-2): 9-15.

Voskuhl Rhonda R, Pribyl Thomas M, Kampf Kathy, Handley Vance, Liu Hong-biao, Feng JiMing, Campagnoni Celia W, Soldan Samantha S, Messing Albee, Campagnoni Anthony T   Experimental autoimmune encephalomyelitis relapses are reduced in heterozygous golli MBP knockout mice Journal of neuroimmunology, 2003; 139(1-2): 44-50.

Maverakis Emanual, Beech Jonathan, Stevens David B, Ametani Akio, Brossay Laurent, van den Elzen Peter, Mendoza Richard, Thai Quoc, Macias Luis H, Ethell Doug, Campagnoni Celia W, Campagnoni Anthony T, Sette Alessandro, Sercarz Eli E   Autoreactive T cells can be protected from tolerance induction through competition by flanking determinants for access to class II MHC Proceedings of the National Academy of Sciences of the United States of America, 2003; 100(9): 5342-7.

Kaur Jaspreet, Libich David S, Campagnoni Celia W, Wood D Denise, Moscarello Mario A, Campagnoni Anthony T, Harauz George   Expression and properties of the recombinant murine Golli-myelin basic protein isoform J37 Journal of neuroscience research, 2003; 71(6): 777-84.

Jacobs Erin C, Bongarzone Ernesto R, Campagnoni Celia W, Kampf Kathy, Campagnoni Anthony T   Soma-restricted products of the myelin proteolipid gene are expressed primarily in neurons in the developing mouse nervous system Developmental neuroscience, 2003; 25(2-4): 96-104.

Reyes Samuel D, Campagnoni Anthony T   Two separate domains in the golli myelin basic proteins are responsible for nuclear targeting and process extension in transfected cells Journal of neuroscience research, 2002; 69(5): 587-96.

Feng Ji-Ming, Wu Jiang-Sheng, Campagnoni Anthony T, Chen Wei-Feng   Nonspecific esterase released from thymic macrophages accumulates in the apoptotic thymocytes: an indication for this enzyme participating in the clearance of apoptotic thymocytes European journal of immunology, 2002; 32(5): 1386-92.

Givogri Maria I, Costa Rui M, Schonmann Vilma, Silva Alcino J, Campagnoni Anthony T, Bongarzone Ernesto R   Central nervous system myelination in mice with deficient expression of Notch1 receptor Journal of neuroscience research, 2002; 67(3): 309-20.

Feng Ji Ming, Fernandes Augustine O, Campagnoni Anthony T   Golli-myelin basic proteins delineate the nerve distribution of lymphoid organs Journal of neuroimmunology, 2002; 123(1-2): 1-8.