Anne Andrews, Ph.D.

Professor, Chemistry and Biochemistry

Organic Chemistry

Psychiatry and Biobehavioral Sciences

Physical Chemistry

Member, Biochemistry, Biophysics & Structural Biology GPB Home Area

Brain Research Institute

CTSI

California NanoSystems Institute

Molecular Pharmacology GPB Home Area

Neuroscience GPB Home Area

Senior Research Scientist, Hatos Center for Neuropharmacology

Biography

Dr. Andrews is Richard Metzner Endowed Chair in Clinical Neuropharmacology, and Professor of Psychiatry & Biobehavioral Sciences and Chemistry & Biochemistry at the University of California, Los Angeles. She is a member of the Semel Institute for Neuroscience & Human Behavior, the Hatos Center for Neuropharmacology, and the California NanoSystems Institute. Dr. Andrews received her B.S. in Chemistry from the Pennsylvania State University and earned her Ph.D. in Chemistry as a U.S. Department of Education Fellow working at the National Institute of Mental Health, where she was later a postdoctoral fellow and senior staff fellow. At the NIMH, Andrews and her mentor, Dr. Dennis Murphy, discovered and characterized a novel serotonin neurotoxin, 2’-NH2-MPTP. Dr. Andrews was also instrumental in early studies on serotonin transporter deficient mice. Andrews is a member of the Society for Neuroscience, American Chemical Society, and Society for Electroanalytical Chemistry. She has been the recipient of an NIH Fellows Award for Research Excellence, an Eli Lily Outstanding Young Analytical Chemist Award, an American Parkinson’s Disease Association Research Award, and a NARSAD Independent Investigator Award. She is a elected member of the American College of Neuropsychopharmacology, a fellow of the Collegium Internationale Neuropsychopharmacologicum, and a Serotonin Club elected councilor. Dr. Andrews is also Associate Editor for ACS Chemical Neuroscience. At UCLA, Andrews leads efforts in basic and translational research on anxiety and depression, and at the nexus of nanoscience and neuroscience. Andrews’ interdisciplinary research team of neuroscientists, biologists, chemists, and engineers focuses on understanding how the serotonin system and particularly, the serotonin transporter, modulate neurotransmission to influence complex behaviors including anxiety, mood, stress responsiveness, and learning and memory. Genetic and pharmacologic mouse models and human gene variants are studied to understand the molecular basis of serotonin system function associated with the etiology and treatment of mood and anxiety disorders. Nanomaterials are designed for fundamental studies on neurotransmitter recognition by native and nonnative binding partners (aptamers) and for the development of in vivo nanobiosensors and functionally directed proteomics.

Claridge Shelley A, Liao Wei-Ssu, Thomas John C, Zhao Yuxi, Cao Huan H, Cheunkar Sarawut, Serino Andrew C, Andrews Anne M, Weiss Paul S   From the bottom up: dimensional control and characterization in molecular monolayers Chemical Society reviews, 2013; 42(7): 2725-45.

Yang Hongyan, Thompson Andrew B, McIntosh Bryan J, Altieri Stefanie C, Andrews Anne M   Physiologically relevant changes in serotonin resolved by fast microdialysis ACS chemical neuroscience, 2013; 4(5): 790-8.

Altieri Stefanie C, Garcia-Garcia Alvaro L, Leonardo E David, Andrews Anne M   Rethinking 5-HT1A receptors: emerging modes of inhibitory feedback of relevance to emotion-related behavior ACS chemical neuroscience, 2013; 4(1): 72-83.

Beikmann Brendan S, Tomlinson Ian D, Rosenthal Sandra J, Andrews Anne Milasincic   Serotonin uptake is largely mediated by platelets versus lymphocytes in peripheral blood cells ACS chemical neuroscience, 2013; 4(1): 161-70.

Andrews Anne M, Daws Lynette C   What's old is new ACS chemical neuroscience, 2013; 4(1): 1-2.

Andrews Anne M   Celebrating serotonin ACS chemical neuroscience, 2012; 3(9): 644-5.

Liao Wei-Ssu, Cheunkar Sarawut, Cao Huan H, Bednar Heidi R, Weiss Paul S, Andrews Anne M   Subtractive patterning via chemical lift-off lithography Science (New York, N.Y.), 2012; 337(6101): 1517-21.

Singh Yogesh S, Sawarynski Lauren E, Dabiri Pasha D, Choi Wonwoo R, Andrews Anne M   Head-to-head comparisons of carbon fiber microelectrode coatings for sensitive and selective neurotransmitter detection by voltammetry Analytical chemistry, 2011; 83(17): 6658-66.

Shuster M J, Vaish A, Cao H H, Guttentag A I, McManigle J E, Gibb A L, Martinez M M, Nezarati R M, Hinds J M, Liao W-S, Weiss P S, Andrews A M   Patterning small-molecule biocapture surfaces: microcontact insertion printing vs. photolithography Chemical communications (Cambridge, England), 2011; 47(38): 10641-3.

Vaish Amit, Liao Wei-Ssu, Shuster Mitchell J, Hinds Jennifer M, Weiss Paul S, Andrews Anne M   Thin gold film-assisted fluorescence spectroscopy for biomolecule sensing Analytical chemistry, 2011; 83(19): 7451-6.

Vaish Amit, Shuster Mitchell J, Cheunkar Sarawut, Weiss Paul S, Andrews Anne M   Tuning stamp surface energy for soft lithography of polar molecules to fabricate bioactive small-molecule microarrays Small (Weinheim an der Bergstrasse, Germany), 2011; 7(10): 1471-9.

Leuchter Andrew F, Cook Ian A, Hamilton Steven P, Narr Katherine L, Toga Arthur, Hunter Aimee M, Faull Kym, Whitelegge Julian, Andrews Anne M, Loo Joseph, Way Baldwin, Nelson Stanley F, Horvath Steven, Lebowitz Barry D   Biomarkers to predict antidepressant response Current psychiatry reports, 2010; 12(6): 553-62.

Singh Yogesh S, Sawarynski Lauren E, Michael Heather M, Ferrell Robert E, Murphey-Corb Michael A, Swain Greg M, Patel Bhavik A, Andrews Anne M   Boron-Doped Diamond Microelectrodes Reveal Reduced Serotonin Uptake Rates in Lymphocytes from Adult Rhesus Monkeys Carrying the Short Allele of the 5-HTTLPR ACS chemical neuroscience, 2010; 1(1): 49-64.

Liu Yansheng, Zhang Jing, Xu Xiaomi, Zhao Moe K, Andrews Anne M, Weber Stephen G   Capillary Ultrahigh Performance Liquid Chromatography with Elevated Temperature for Sub-One Minute Separations of Basal Serotonin in Submicroliter Brain Microdialysate Samples Analytical chemistry, 2010; 82(23): 9611-6.

Daws, L. C., Andrews, A. M., Gerhardt, G. A.   Electrochemical techniques and advances in psychopharmacology, Encyclopedia of Psychopharmacology, 2010; I.P.Stolerman, Ed., in press, Springer: New York: .

Bressler Amanda, Blizard David, Andrews Anne   Low-stress route learning using the Lashley III maze in mice Journal of visualized experiments : JoVE, 2010; 175(39): .

Vaish, A. Shuster, M. J. Cheunkar, S. Singh, Y. S. Weiss, P. S. Andrews, A. M.   Native serotonin membrane receptors recognize 5-hydroxytryptophan-functionalized substrates: Enabling small-molecule recognition ACS Chemical Neuroscience, 2010; 1(7): 495-504.

Luellen, B. A., Gillman, T. L., and Andrews, A. M.   Presynaptic adaptive responses to constitutive versus adult pharmacologic inhibition of serotonin uptake Experimental Models in Serotonin Transporter Research, 2010; A. V. Kalueff and J. L. LaPorte, Eds. Cambridge University Press: Cambridge: 1-42.

Shen Qiuying, Lal Rachnanjali, Luellen Beth A, Earnheart John C, Andrews Anne Milasincic, Luscher Bernhard   gamma-Aminobutyric acid-type A receptor deficits cause hypothalamic-pituitary-adrenal axis hyperactivity and antidepressant drug sensitivity reminiscent of melancholic forms of depression Biological psychiatry, 2010; 68(6): 512-20.

Andrews, A. M.   Does chronic antidepressant treatment increase extracellular serotonin?, Frontiers in Neuroscience, 2009; 3(2): p. 246-247.

Shuster, M. J., Vaish, A., Szapacs, M. E., Anderson, M. E., Weiss, P. S., and Andrews, A. M.   Biospecific recognition of tethered small molecules diluted in self-assembled monolayers Advanced Materials , 2008; 20: p. 164-167.

Guiard Bruno P, David Denis J P, Deltheil Thierry, Chenu Franck, Le Maître Erwan, Renoir Thibault, Leroux-Nicollet Isabelle, Sokoloff Pierre, Lanfumey Laurence, Hamon Michel, Andrews Anne M, Hen René, Gardier Alain M   Brain-derived neurotrophic factor-deficient mice exhibit a hippocampal hyperserotonergic phenotype The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), 2008; 11(1): 79-92.

Murphy Dennis L, Fox Meredith A, Timpano Kiara R, Moya Pablo R, Ren-Patterson Renee, Andrews Anne M, Holmes Andrew, Lesch Klaus-Peter, Wendland Jens R   How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems Neuropharmacology, 2008; 55(6): 932-60.

Mullen, T. J., Srinivasan, C., Shuster, M. J., Horn, M. W., Andrews, A. M., and Weiss, P. S.   Hybrid approaches to nanometer-scale patterning: Exploiting tailored intermolecular interactions Journal of Nanoparticle Research, 2008; 10(8): 1231-1240.

Fox Meredith A, Andrews Anne M, Wendland Jens R, Lesch Klaus-Peter, Holmes Andrew, Murphy Dennis L   A pharmacological analysis of mice with a targeted disruption of the serotonin transporter Psychopharmacology, 2007; 195(2): 147-66.

Perez, X. A., Bressler, A. J., and Andrews, A. M.   Determining serotonin and dopamine uptake rates in synaptosomes using high-speed chronoamperometry Electrochemical Methods of Neurotransmitter Analysis, 2007; A.C. Michael and L.M. Borland, Eds.,CRC Press LLC: Boca Raton.

Mullen, T. J., Srinivasan, C., Hohman, J. N., Gillmor, S. D., Shuster, M. J., Horn, M. W., Andrews, A. M., and Weiss, P. S.   Microcontact insertion printing Applied Physics Letters, 2007; 90(6): p. 063114 (063111-063113).

Luellen, B. A., Bianco, L. E., Schneider, L. M., and Andrews, A. M.   Reduced brain-derived neurotrophic factor is associated with a loss of serotonergic innervation in the hippocampus of aging mice Genes Brain and Behavior, 2007; 6: p. 482-490.

Counterman Anne E, D'Onofrio Terrence G, Andrews Anne Milasincic, Weiss Paul S   A physical model of axonal damage due to oxidative stress Proceedings of the National Academy of Sciences of the United States of America, 2006; 103(14): 5262-6.

Perez Xiomara A, Bianco Laura E, Andrews Anne M   Filtration disrupts synaptosomes during radiochemical analysis of serotonin uptake: comparison with chronoamperometry in SERT knockout mice Journal of neuroscience methods, 2006; 154(1-2): 245-55.

Unger Erica L, Eve David J, Perez Xiomara A, Reichenbach Dawn K, Xu Yanqun, Lee Michael K, Andrews Anne M   Locomotor hyperactivity and alterations in dopamine neurotransmission are associated with overexpression of A53T mutant human alpha-synuclein in mice Neurobiology of disease, 2006; 21(2): 431-43.

Luellen Beth A, Szapacs Matthew E, Materese Christopher K, Andrews Anne M   The neurotoxin 2'-NH2-MPTP degenerates serotonin axons and evokes increases in hippocampal BDNF Neuropharmacology, 2006; 50(3): 297-308.

Kim Dong-Kyu, Tolliver Teresa J, Huang Su-Jan, Martin Bradley J, Andrews Anne M, Wichems Christine, Holmes Andrew, Lesch Klaus-Peter, Murphy Dennis L   Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter Neuropharmacology, 2005; 49(6): 798-810.

Perez Xiomara A, Andrews Anne M   Chronoamperometry to determine differential reductions in uptake in brain synaptosomes from serotonin transporter knockout mice Analytical chemistry, 2005; 77(3): 818-26.

Szapacs Matthew E, Mathews Tiffany A, Tessarollo Lino, Ernest Lyons W, Mamounas Laura A, Andrews Anne M   Exploring the relationship between serotonin and brain-derived neurotrophic factor: analysis of BDNF protein and extraneuronal 5-HT in mice with reduced serotonin transporter or BDNF expression Journal of neuroscience methods, 2004; 140(1-2): 81-92.

Mathews Tiffany A, Fedele Denise E, Coppelli Francesca M, Avila Amy M, Murphy Dennis L, Andrews Anne M   Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression Journal of neuroscience methods, 2004; 140(1-2): 169-81.

Szapacs Matthew E, Numis Adam L, Andrews Anne M   Late onset loss of hippocampal 5-HT and NE is accompanied by increases in BDNF protein expression in mice co-expressing mutant APP and PS1 Neurobiology of disease, 2004; 16(3): 572-80.

Numis Adam L, Unger Erica L, Sheridan Douglas L, Chisnell Angela C, Andrews Anne M   The role of membrane and vesicular monoamine transporters in the neurotoxic and hypothermic effects of 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine (2'-NH(2)-MPTP) Molecular pharmacology, 2004; 66(3): 718-27.

Luellen Beth A, Miller Diane B, Chisnell Angela C, Murphy Dennis L, O'Callaghan James P, Andrews Anne Milasincic   Neuronal and astroglial responses to the serotonin and norepinephrine neurotoxin: 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine The Journal of pharmacology and experimental therapeutics, 2003; 307(3): 923-31.

Unger Erica L, Mazzola-Pomietto Pascale, Murphy Dennis L, Andrews Anne M   2'-NH(2)-MPTP [1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine] depletes serotonin and norepinephrine in rats: a comparison with 2'-CH(3)-MPTP [1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine] The Journal of pharmacology and experimental therapeutics, 2002; 303(2): 527-33.

Donovan Stacy L, Mamounas Laura A, Andrews Anne M, Blue Mary E, McCasland James S   GAP-43 is critical for normal development of the serotonergic innervation in forebrain The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002; 22(9): 3543-52.

Murphy, D. L., Li, Q., Engel, S., Wichems, C., Andrews, A., Lesch, K. P., and Uhl, G.   Genetic perspectives on the serotonin transporter Brain Research Bulletin, 2001; 56(5): p. 487-494.

Sora, I., Hall, F. S., Andrews, A. M., Itokawa, M., Li, X. F., Wei, H. B., Wichems, C., Lesch, K. P., Murphy, D. L., and Uhl, G. R.   Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference Proceedings of the National Academy of Sciences of the United States of America, 2001; 98(9): p. 5300-3055.

Andrews, A. M.   The use of 2'-NH2-MPTP as a tool to probe central serotonin and norepinephrine neurotransmitter systems, Neurotransmissions, 2000; 16: p.18-21.

Jayanthi, S., Ladenheim, B., Andrews, A. M., and Cadet, J. L.   Overexpression of human copper/zinc superoxide dismutase in transgenic mice attenuates oxidative stress caused by methylenedioxymethamphetamine (Ecstasy) Neuroscience, 1999; 91(4): p.1379-1387.

Bengel, D., Murphy, D. L., Andrews, A. M., Wichems, C. H., Feltner, D., Heils, A., Mossner, R., Westphal, H., and Lesch, K. P.   Altered brain serotonin homeostasis and locomotor insensitivity to 3,4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice Molecular Pharmacology, 1998; 53(4): p. 649-655.

Murphy, D. L., Andrews, A. M., Wichems, C. H., Li, Q., Tohda, M., and Greenberg, B.   Brain serotonin neurotransmission: An overview and update with an emphasis on serotonin subsystem heterogeneity, multiple receptors, interactions with other neurotransmitter systems, and consequent implications for understanding the actions of serotonergic drugs Journal of Clinical Psychiatry, 1998; 59(Suppl 15): p.4-12.

Tsao, L. I., Ladenheim, B., Andrews, A. M., Chiueh, C. C., Cadet, J. L., and Su, T. P.   Delta opioid peptide [D-Ala2,D-leu5]enkephalin blocks the long-term loss of dopamine transporters induced by multiple administrations of methamphetamine: involvement of opioid receptors and reactive oxygen species Journal of Pharmacology and Experimental Therapeutics, 1998; 287(1): 322-331.

Bengel, D., Jöhren, O., Andrews, A. M., Heils, A., Mössner, R., Sanvitto, G. L., Saavedra, J. M., Lesch, K.-P., and Murphy, D. L.   Cellular localization and expression of the serotonin transporter in mouse brain Brain Research, 1997; 778(2): p. 338-345.

Bengel, D., Heils, A., Petri, S., Seemann, M., Glatz, K., Andrews, A., Murphy, D. L., and Lesch, K. P.   Gene structure and 5'-flanking regulatory region of the murine serotonin transporter Brain Research: Molecular Brain Research, 1997; 44(2): 286-92.

Tella, S. R., Ladenheim, B., Andrews, A. M., Goldberg, S. R., and Cadet, J. L.   Differential reinforcing effects of cocaine and GBR-12909: biochemical evidence for divergent neuroadaptive changes in the mesolimbic dopaminergic system Journal Neuroscience, 1996; 16(23): p. 7416-7427.

Andrews, A. M., Ladenheim, B., Epstein, C. J., Cadet, J. L., and Murphy, D. L.   Transgenic mice with high levels of superoxide dismutase activity are protected from the neurotoxic effects of 2'-NH2-MPTP on serotonergic and noradrenergic nerve terminals Molecular Pharmacology, 1996; 50(6): p. 1511-1519.

Andrews, A. M. and Murphy, D. L.   2'-NH2-MPTP in Swiss Webster mice: evidence for long-term (6-month) depletions in cortical and hippocampal serotonin and norepinephrine, differential protection by selective uptake inhibitors or clorgyline and functional changes in central serotonin neurotransmission Journal of Pharmacology and Experimental Therapeutics, 1993; 267(3): p. 1432-1439.

Andrews, A. M. and Murphy, D. L.   Fluoxetine and desipramine selectively attenuate 2'-NH2-MPTP-induced depletions in serotonin and norepinephrine European Journal of Pharmacology, 1993; 250(2): p. 215-221.

Andrews, A. M. and Murphy, D. L.   Sustained depletion of cortical and hippocampal serotonin and norepinephrine but not striatal dopamine by 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine (2'-NH2-MPTP): a comparative study with 2'-CH3-MPTP and MPTP Journal of Neurochemistry, 1993; 60(3): p. 1167-1170.

Andrews Anne M   Visual inspiration and cover art ACS chemical neuroscience, 2012; 3(7): 492.

Alivisatos A Paul, Andrews Anne M, Boyden Edward S, Chun Miyoung, Church George M, Deisseroth Karl, Donoghue John P, Fraser Scott E, Lippincott-Schwartz Jennifer, Looger Loren L, Masmanidis Sotiris, McEuen Paul L, Nurmikko Arto V, Park Hongkun, Peterka Darcy S, Reid Clay, Roukes Michael L, Scherer Axel, Schnitzer Mark, Sejnowski Terrence J, Shepard Kenneth L, Tsao Doris, Turrigiano Gina, Weiss Paul S, Xu Chris, Yuste Rafael, Zhuang Xiaowei   Nanotools for neuroscience and brain activity mapping ACS nano, 2013; 7(3): 1850-66.

Vaish Amit, Shuster Mitchell J, Cheunkar Sarawut, Singh Yogesh S, Weiss Paul S, Andrews Anne M   Native serotonin membrane receptors recognize 5-hydroxytryptophan-functionalized substrates: enabling small-molecule recognition ACS chemical neuroscience, 2010; 1(7): 495-504.

Omiatek Donna M, Bressler Amanda J, Cans Ann-Sofie, Andrews Anne M, Heien Michael L, Ewing Andrew G   The real catecholamine content of secretory vesicles in the CNS revealed by electrochemical cytometry Scientific reports, 2013; 3(3): 1447.

Moya Pablo R, Wendland Jens R, Rubenstein Liza M, Timpano Kiara R, Heiman Gary A, Tischfield Jay A, King Robert A, Andrews Anne M, Ramamoorthy Samanda, McMahon Francis J, Murphy Dennis L   Common and rare alleles of the serotonin transporter gene, SLC6A4, associated with Tourette's disorder Movement disorders : official journal of the Movement Disorder Society, 2013; 28(9): 1263-70.

Andrews Anne M, Weiss Paul S   Nano in the brain: nano-neuroscience ACS nano, 2012; 6(10): 8463-4.

Srinivasan Charan, Mullen Thomas J, Hohman J Nathan, Anderson Mary E, Dameron Arrelaine A, Andrews Anne M, Dickey Elizabeth C, Horn Mark W, Weiss Paul S   Scanning electron microscopy of nanoscale chemical patterns ACS nano, 2007; 1(3): 191-201.

Andrews Anne M   The BRAIN Initiative: toward a chemical connectome ACS chemical neuroscience, 2013; 4(5): 645.