Towards a systems view of IBS.
Title | Towards a systems view of IBS. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Mayer EA, Labus JS, Tillisch K, Cole SW, Baldi P |
Journal | Nat Rev Gastroenterol Hepatol |
Volume | 12 |
Issue | 10 |
Pagination | 592-605 |
Date Published | 2015 Oct |
ISSN | 1759-5053 |
Keywords | Environment, Humans, Immune System, Irritable Bowel Syndrome, Models, Biological, Nervous System |
Abstract | Despite an extensive body of reported information about peripheral and central mechanisms involved in the pathophysiology of IBS symptoms, no comprehensive disease model has emerged that would guide the development of novel, effective therapies. In this Review, we will first describe novel insights into some key components of brain-gut interactions, starting with the emerging findings of distinct functional and structural brain signatures of IBS. We will then point out emerging correlations between these brain networks and genomic, gastrointestinal, immune and gut-microbiome-related parameters. We will incorporate this new information, as well as the reported extensive literature on various peripheral mechanisms, into a systems-based disease model of IBS, and discuss the implications of such a model for improved understanding of the disorder, and for the development of more-effective treatment approaches in the future. |
DOI | 10.1038/nrgastro.2015.121 |
Alternate Journal | Nat Rev Gastroenterol Hepatol |
PubMed ID | 26303675 |
PubMed Central ID | PMC5001844 |
Grant List | P30 DK041301 / DK / NIDDK NIH HHS / United States P50 DK064539 / DK / NIDDK NIH HHS / United States R01 DK048351 / DK / NIDDK NIH HHS / United States R01 DK048351 / DK / NIDDK NIH HHS / United States |