OPTIMUM: Optimize Your Treatment For Depression

Study Detail

OPTIMUM is a research study designed to test medications for older adults with depression suffering from treatment resistant depression. The study is designed to test which medications work best and are safest for older adults.


Older adults experiencing major depression that persist despite treat,ment with two or more standard antidepressants may be eligible.

Age 60 years and older
Treatmetn resistant depression- major depression (PHQ-9=>6) who failed two or more trials of antidepressants.

Dementia; Unstable medical illness; unable to take medications prescribed in the OPTIMUM study (aripiprazole, Bupropione, Lithiuml Nortriptyline)

In order to refer a patient, please email: LateLifeWellness@mednet.ucla.edu or call 310 794-4619 0r 310-206-5240

Project: Optimize Your Treatment For Depression