Why sleep is important for health: a psychoneuroimmunology perspective.
Title | Why sleep is important for health: a psychoneuroimmunology perspective. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Irwin MR |
Journal | Annu Rev Psychol |
Volume | 66 |
Pagination | 143-72 |
Date Published | 2015 Jan 3 |
ISSN | 1545-2085 |
Keywords | Humans, Immune System, Inflammation, Psychoneuroimmunology, Sleep, Sleep Wake Disorders |
Abstract | Sleep has a critical role in promoting health. Research over the past decade has documented that sleep disturbance has a powerful influence on the risk of infectious disease, the occurrence and progression of several major medical illnesses including cardiovascular disease and cancer, and the incidence of depression. Increasingly, the field has focused on identifying the biological mechanisms underlying these effects. This review highlights the impact of sleep on adaptive and innate immunity, with consideration of the dynamics of sleep disturbance, sleep restriction, and insomnia on (a) antiviral immune responses with consequences for vaccine responses and infectious disease risk and (b) proinflammatory immune responses with implications for cardiovascular disease, cancer, and depression. This review also discusses the neuroendocrine and autonomic neural underpinnings linking sleep disturbance and immunity and the reciprocal links between sleep and inflammatory biology. Finally, interventions are discussed as effective strategies to improve sleep, and potential opportunities are identified to promote sleep health for therapeutic control of chronic infectious, inflammatory, and neuropsychiatric diseases. |
DOI | 10.1146/annurev-psych-010213-115205 |
Alternate Journal | Annu Rev Psychol |
PubMed ID | 25061767 |
PubMed Central ID | PMC4961463 |
Grant List | R01 AG026364 / AG / NIA NIH HHS / United States R01 AG034588 / AG / NIA NIH HHS / United States R01 CA119159 / CA / NCI NIH HHS / United States R01 CA160245 / CA / NCI NIH HHS / United States R01 DA032922 / DA / NIDA NIH HHS / United States R01 HL079955 / HL / NHLBI NIH HHS / United States R01 HL095799 / HL / NHLBI NIH HHS / United States |