Sympathetic nervous system regulation of the tumour microenvironment.
Title | Sympathetic nervous system regulation of the tumour microenvironment. |
Publication Type | Journal Article |
Year of Publication | 2015 |
Authors | Cole SW, Nagaraja AS, Lutgendorf SK, Green PA, Sood AK |
Journal | Nat Rev Cancer |
Volume | 15 |
Issue | 9 |
Pagination | 563-72 |
Date Published | 2015 Sep |
ISSN | 1474-1768 |
Keywords | Cell Differentiation, Epithelial-Mesenchymal Transition, Gene Expression Regulation, Neoplastic, Humans, Neoplasms, Neovascularization, Pathologic, Sympathetic Nervous System, Tumor Microenvironment |
Abstract | The peripheral autonomic nervous system (ANS) is known to regulate gene expression in primary tumours and their surrounding microenvironment. Activation of the sympathetic division of the ANS in particular modulates gene expression programmes that promote metastasis of solid tumours by stimulating macrophage infiltration, inflammation, angiogenesis, epithelial-mesenchymal transition and tumour invasion, and by inhibiting cellular immune responses and programmed cell death. Haematological cancers are modulated by sympathetic nervous system (SNS) regulation of stem cell biology and haematopoietic differentiation programmes. In addition to identifying a molecular basis for physiologic stress effects on cancer, these findings have also identified new pharmacological strategies to inhibit cancer progression in vivo. |
DOI | 10.1038/nrc3978 |
Alternate Journal | Nat. Rev. Cancer |
PubMed ID | 26299593 |
PubMed Central ID | PMC4828959 |
Grant List | AG017265 / AG / NIA NIH HHS / United States AG033590 / AG / NIA NIH HHS / United States CA083639 / CA / NCI NIH HHS / United States CA098258 / CA / NCI NIH HHS / United States CA104825 / CA / NCI NIH HHS / United States CA109298 / CA / NCI NIH HHS / United States CA116778 / CA / NCI NIH HHS / United States CA140933 / CA / NCI NIH HHS / United States CA151668 / CA / NCI NIH HHS / United States CA177909 / CA / NCI NIH HHS / United States P30 AG017265 / AG / NIA NIH HHS / United States P30 CA016672 / CA / NCI NIH HHS / United States P50 CA083639 / CA / NCI NIH HHS / United States P50 CA098258 / CA / NCI NIH HHS / United States R01 CA104825 / CA / NCI NIH HHS / United States R01 CA109298 / CA / NCI NIH HHS / United States R01 CA116778 / CA / NCI NIH HHS / United States R01 CA140933 / CA / NCI NIH HHS / United States R01 CA177909 / CA / NCI NIH HHS / United States R37 AG033590 / AG / NIA NIH HHS / United States U54 CA151668 / CA / NCI NIH HHS / United States |