Stromal cell expression of caveolin-1 predicts outcome in breast cancer.

TitleStromal cell expression of caveolin-1 predicts outcome in breast cancer.
Publication TypeJournal Article
Year of Publication2009
AuthorsSloan EK, Ciocca DR, Pouliot N, Natoli A, Restall C, Henderson MA, Fanelli MA, Cuello-Carrión FD, Gago FE, Anderson RL
JournalAm J Pathol
Date Published2009 Jun
KeywordsAdult, Aged, Aged, 80 and over, Animals, Biomarkers, Tumor, Breast Neoplasms, Caveolin 1, Female, Humans, Kaplan-Meier Estimate, Mice, Mice, Knockout, Mice, Transgenic, Middle Aged, Neoplasm Invasiveness, Neoplasm Staging, Receptor, ErbB-2, Receptors, Estrogen, Receptors, Progesterone, Receptors, Virus, Stromal Cells, Treatment Outcome

Caveolin-1 has been linked to tumor progression and clinical outcome in breast cancer, but a clear resolution of its role as a prognostic marker is lacking. We assessed caveolin-1 levels in normal breast tissue and two breast cancer cohorts for which outcome data were available. We found that caveolin-1 was not expressed in normal breast luminal epithelium but was present in the epithelial compartment of some tumors. We found no association between caveolin-1 expression in the epithelial compartment and clinical outcome. However, high levels of caveolin-1 in the stromal tissue surrounding the tumor, rather than within tumor cells, associated strongly with reduced metastasis and improved survival (P < 0.0001). The onset of mammary tumors driven by Her2/neu overexpression was accelerated in mice lacking caveolin-1, thereby supporting the observation that the presence of caveolin-1 in the tumor microenvironment modulates tumor development. These studies suggest that stromal caveolin-1 expression may be a potential therapeutic target and a valuable prognostic indicator of breast cancer progression.

Alternate JournalAm. J. Pathol.
PubMed ID19411449
PubMed Central IDPMC2684169
Grant ListR0I CA90291 / CA / NCI NIH HHS / United States