Stress-induced remodeling of lymphoid innervation.

TitleStress-induced remodeling of lymphoid innervation.
Publication TypeJournal Article
Year of Publication2008
AuthorsSloan EK, Capitanio JP, Cole SW
JournalBrain Behav Immun
Date Published2008 Jan
KeywordsAdrenergic beta-Antagonists, Animals, Humans, Immune System, Kinetics, Lymphoid Tissue, Nerve Growth Factors, Nervous System, Stress, Physiological

Lymphoid organs have long been known to harbor neural fibers from the sympathetic division of the autonomic nervous system, but recent studies suggest a surprising degree of plasticity in the density of innervation. This review summarizes data showing that behavioral stress can increase the density of catecholaminergic neural fibers within lymphoid organs of adult primates. Stress-induced neural densification is associated with increased expression of neurotrophic factors, and functional consequences include alterations in lymph node cytokine expression and increased replication of a lymphotropic virus. The finding that behavioral stress can tonically alter lymph node neural structure suggests that behavioral factors could exert long-term regulatory influences on the initiation, maintenance, and resolution of immune responses.

Alternate JournalBrain Behav. Immun.
PubMed ID17697764
PubMed Central IDPMC2754291
Grant ListAI052737 / AI / NIAID NIH HHS / United States
MH049033 / MH / NIMH NIH HHS / United States
R01 AI052737 / AI / NIAID NIH HHS / United States
R01 AI052737-04 / AI / NIAID NIH HHS / United States
RR000169 / RR / NCRR NIH HHS / United States