Stress hormones regulate interleukin-6 expression by human ovarian carcinoma cells through a Src-dependent mechanism.

TitleStress hormones regulate interleukin-6 expression by human ovarian carcinoma cells through a Src-dependent mechanism.
Publication TypeJournal Article
Year of Publication2007
AuthorsNilsson MB, Armaiz-Pena G, Takahashi R, Lin YG, Trevino J, Li Y, Jennings N, Arevalo J, Lutgendorf SK, Gallick GE, Sanguino AM, Lopez-Berestein G, Cole SW, Sood AK
JournalJ Biol Chem
Volume282
Issue41
Pagination29919-26
Date Published2007 Oct 12
ISSN0021-9258
KeywordsAnimals, Cell Line, Tumor, Disease Progression, Dose-Response Relationship, Drug, Female, Gene Expression Regulation, Neoplastic, Humans, Interleukin-6, Mice, Neoplasm Transplantation, Neovascularization, Pathologic, Norepinephrine, Ovarian Neoplasms, src-Family Kinases
Abstract

Recent studies have demonstrated that chronic stress promotes tumor growth, angiogenesis, and metastasis. In ovarian cancer, levels of the pro-angiogenic cytokine, interleukin 6 (IL-6), are known to be elevated in individuals experiencing chronic stress, but the mechanism(s) by which this cytokine is regulated and its role in tumor growth remain under investigation. Here we show that stress hormones such as norepinephrine lead to increased expression of IL-6 mRNA and protein levels in ovarian carcinoma cells. Furthermore, we demonstrate that norepinephrine stimulation activates Src tyrosine kinase and this activation is required for increased IL-6 expression. These results demonstrate that stress hormones activate signaling pathways known to be critical in ovarian tumor progression.

DOI10.1074/jbc.M611539200
Alternate JournalJ. Biol. Chem.
PubMed ID17716980
Grant ListCA109298 / CA / NCI NIH HHS / United States
CA110793 / CA / NCI NIH HHS / United States
P50 CA 083639 / CA / NCI NIH HHS / United States