Stress hormones regulate interleukin-6 expression by human ovarian carcinoma cells through a Src-dependent mechanism.
Title | Stress hormones regulate interleukin-6 expression by human ovarian carcinoma cells through a Src-dependent mechanism. |
Publication Type | Journal Article |
Year of Publication | 2007 |
Authors | Nilsson MB, Armaiz-Pena G, Takahashi R, Lin YG, Trevino J, Li Y, Jennings N, Arevalo J, Lutgendorf SK, Gallick GE, Sanguino AM, Lopez-Berestein G, Cole SW, Sood AK |
Journal | J Biol Chem |
Volume | 282 |
Issue | 41 |
Pagination | 29919-26 |
Date Published | 2007 Oct 12 |
ISSN | 0021-9258 |
Keywords | Animals, Cell Line, Tumor, Disease Progression, Dose-Response Relationship, Drug, Female, Gene Expression Regulation, Neoplastic, Humans, Interleukin-6, Mice, Neoplasm Transplantation, Neovascularization, Pathologic, Norepinephrine, Ovarian Neoplasms, src-Family Kinases |
Abstract | Recent studies have demonstrated that chronic stress promotes tumor growth, angiogenesis, and metastasis. In ovarian cancer, levels of the pro-angiogenic cytokine, interleukin 6 (IL-6), are known to be elevated in individuals experiencing chronic stress, but the mechanism(s) by which this cytokine is regulated and its role in tumor growth remain under investigation. Here we show that stress hormones such as norepinephrine lead to increased expression of IL-6 mRNA and protein levels in ovarian carcinoma cells. Furthermore, we demonstrate that norepinephrine stimulation activates Src tyrosine kinase and this activation is required for increased IL-6 expression. These results demonstrate that stress hormones activate signaling pathways known to be critical in ovarian tumor progression. |
DOI | 10.1074/jbc.M611539200 |
Alternate Journal | J. Biol. Chem. |
PubMed ID | 17716980 |
Grant List | CA109298 / CA / NCI NIH HHS / United States CA110793 / CA / NCI NIH HHS / United States P50 CA 083639 / CA / NCI NIH HHS / United States |