Sleep disturbance, inflammation and depression risk in cancer survivors.

TitleSleep disturbance, inflammation and depression risk in cancer survivors.
Publication TypeJournal Article
Year of Publication2013
AuthorsIrwin MR, Olmstead RE, Ganz PA, Haque R
JournalBrain Behav Immun
Volume30 Suppl
PaginationS58-67
Date Published2013 Mar
ISSN1090-2139
KeywordsDepression, Depressive Disorder, Humans, Inflammation, Neoplasms, Quality of Life, Risk, Sleep Wake Disorders, Survivors
Abstract

Over two-thirds of the 11.4 million cancer survivors in the United States can expect long-term survival, with many others living with cancer as a chronic disease controlled by ongoing therapy. However, behavioral co-morbidities often arise during treatment and persist long-term to complicate survival and reduce quality of life. In this review, the inter-relationships between cancer, depression, and sleep disturbance are described, with a focus on the role of sleep disturbance as a risk factor for depression. Increasing evidence also links alterations in inflammatory biology dynamics to these long-term effects of cancer diagnosis and treatment, and the hypothesis that sleep disturbance drives inflammation, which together contribute to depression, is discussed. Better understanding of the associations between inflammation and behavioral co-morbidities has the potential to refine prediction of risk and development of strategies for the prevention and treatment of sleep disturbance and depression in cancer survivors.

DOI10.1016/j.bbi.2012.05.002
Alternate JournalBrain Behav. Immun.
PubMed ID22634367
PubMed Central IDPMC3435451
Grant ListP30 AG028748 / AG / NIA NIH HHS / United States
P30-AG028748 / AG / NIA NIH HHS / United States
R01 AG026364 / AG / NIA NIH HHS / United States
R01 AG034588 / AG / NIA NIH HHS / United States
R01 CA119159 / CA / NCI NIH HHS / United States
R01 CA160245 / CA / NCI NIH HHS / United States
R01 HL079955 / HL / NHLBI NIH HHS / United States
R01 HL095799 / HL / NHLBI NIH HHS / United States
R01 HL095799 / HL / NHLBI NIH HHS / United States
R01-AG026364 / AG / NIA NIH HHS / United States
R01-AG034588 / AG / NIA NIH HHS / United States
R01-CA109650 / CA / NCI NIH HHS / United States
R01-CA119159 / CA / NCI NIH HHS / United States
R01-HL079955 / HL / NHLBI NIH HHS / United States
R01CA136743-01A2 / CA / NCI NIH HHS / United States
UL RR 033176 / RR / NCRR NIH HHS / United States
UL1 TR000124 / TR / NCATS NIH HHS / United States