Sleep disturbance, inflammation and depression risk in cancer survivors.
Title | Sleep disturbance, inflammation and depression risk in cancer survivors. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Irwin MR, Olmstead RE, Ganz PA, Haque R |
Journal | Brain Behav Immun |
Volume | 30 Suppl |
Pagination | S58-67 |
Date Published | 2013 Mar |
ISSN | 1090-2139 |
Keywords | Depression, Depressive Disorder, Humans, Inflammation, Neoplasms, Quality of Life, Risk, Sleep Wake Disorders, Survivors |
Abstract | Over two-thirds of the 11.4 million cancer survivors in the United States can expect long-term survival, with many others living with cancer as a chronic disease controlled by ongoing therapy. However, behavioral co-morbidities often arise during treatment and persist long-term to complicate survival and reduce quality of life. In this review, the inter-relationships between cancer, depression, and sleep disturbance are described, with a focus on the role of sleep disturbance as a risk factor for depression. Increasing evidence also links alterations in inflammatory biology dynamics to these long-term effects of cancer diagnosis and treatment, and the hypothesis that sleep disturbance drives inflammation, which together contribute to depression, is discussed. Better understanding of the associations between inflammation and behavioral co-morbidities has the potential to refine prediction of risk and development of strategies for the prevention and treatment of sleep disturbance and depression in cancer survivors. |
DOI | 10.1016/j.bbi.2012.05.002 |
Alternate Journal | Brain Behav. Immun. |
PubMed ID | 22634367 |
PubMed Central ID | PMC3435451 |
Grant List | P30 AG028748 / AG / NIA NIH HHS / United States P30-AG028748 / AG / NIA NIH HHS / United States R01 AG026364 / AG / NIA NIH HHS / United States R01 AG034588 / AG / NIA NIH HHS / United States R01 CA119159 / CA / NCI NIH HHS / United States R01 CA160245 / CA / NCI NIH HHS / United States R01 HL079955 / HL / NHLBI NIH HHS / United States R01 HL095799 / HL / NHLBI NIH HHS / United States R01 HL095799 / HL / NHLBI NIH HHS / United States R01-AG026364 / AG / NIA NIH HHS / United States R01-AG034588 / AG / NIA NIH HHS / United States R01-CA109650 / CA / NCI NIH HHS / United States R01-CA119159 / CA / NCI NIH HHS / United States R01-HL079955 / HL / NHLBI NIH HHS / United States R01CA136743-01A2 / CA / NCI NIH HHS / United States UL RR 033176 / RR / NCRR NIH HHS / United States UL1 TR000124 / TR / NCATS NIH HHS / United States |