Positive affect and inflammation during radiation treatment for breast and prostate cancer.
Title | Positive affect and inflammation during radiation treatment for breast and prostate cancer. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Sepah SC, Bower JE |
Journal | Brain Behav Immun |
Volume | 23 |
Issue | 8 |
Pagination | 1068-72 |
Date Published | 2009 Nov |
ISSN | 1090-2139 |
Keywords | Adult, Affect, Aged, Breast Neoplasms, Female, Humans, Immunoassay, Inflammation, Interleukin-1beta, Interleukin-6, Male, Middle Aged, Patient Selection, Prostatic Neoplasms, Self-Assessment, Surveys and Questionnaires |
Abstract | There is growing evidence that positive affect may influence health and immune function, although few studies have examined links between positive affect and immune processes in clinical populations. The purpose of this study was to examine whether positive affect is associated with changes in proinflammatory cytokines in cancer patients undergoing radiation treatment. Subjects were 50 individuals with early-stage breast and prostate cancer who completed psychosocial questionnaires and provided blood samples at seven time points before, during, and after radiation treatment. Positive affect was assessed before treatment onset using the CES-D (Center for Epidemiological Studies Depression Scale). Blood samples were assayed for serum levels of proinflammatory cytokines IL-1beta and IL-6. Patients with higher levels of positive affect before treatment exhibited higher mean levels of IL-1beta and IL-6 during radiation treatment (all ps<.05). Results suggest that positive affect enhances the acute inflammatory response to radiation treatment, perhaps facilitating tissue repair processes. |
DOI | 10.1016/j.bbi.2009.06.149 |
Alternate Journal | Brain Behav. Immun. |
PubMed ID | 19559785 |
PubMed Central ID | PMC2908236 |
Grant List | K07 CA090407 / CA / NCI NIH HHS / United States K07 CA090407-01 / CA / NCI NIH HHS / United States K07 CA090407-02 / CA / NCI NIH HHS / United States K07 CA090407-03 / CA / NCI NIH HHS / United States K07 CA090407-04 / CA / NCI NIH HHS / United States K07 CA090407-05 / CA / NCI NIH HHS / United States K07 CA090407-06 / CA / NCI NIH HHS / United States K07 CA90407 / CA / NCI NIH HHS / United States |