A pilot study of yogic meditation for family dementia caregivers with depressive symptoms: effects on mental health, cognition, and telomerase activity.
|Title||A pilot study of yogic meditation for family dementia caregivers with depressive symptoms: effects on mental health, cognition, and telomerase activity.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Lavretsky H, Epel ES, Siddarth P, Nazarian N, St Cyr N, Khalsa DS, Lin J, Blackburn E, Irwin MR|
|Journal||Int J Geriatr Psychiatry|
|Date Published||2013 Jan|
|Keywords||Aged, Caregivers, Cognition, Dementia, Depressive Disorder, Family, Female, Humans, Leukocytes, Mononuclear, Male, Meditation, Middle Aged, Pilot Projects, Telomerase, Yoga|
BACKGROUND: This study examined the effects of brief daily yogic meditation on mental health, cognitive functioning, and immune cell telomerase activity in family dementia caregivers with mild depressive symptoms.
METHODS: Thirty-nine family dementia caregivers (mean age 60.3 years old (SD = 10.2)) were randomized to practicing Kirtan Kriya or listening to relaxation music for 12 min per day for 8 weeks. The severity of depressive symptoms, mental and cognitive functioning were assessed at baseline and follow-up. Telomerase activity in peripheral blood mononuclear cells (PMBC) was examined in peripheral PBMC pre-intervention and post-intervention.
RESULTS: The meditation group showed significantly lower levels of depressive symptoms and greater improvement in mental health and cognitive functioning compared with the relaxation group. In the meditation group, 65.2% showed 50% improvement on the Hamilton Depression Rating scale and 52% of the participants showed 50% improvement on the Mental Health Composite Summary score of the Short Form-36 scale compared with 31.2% and 19%, respectively, in the relaxation group (p < 0.05). The meditation group showed 43% improvement in telomerase activity compared with 3.7% in the relaxation group (p = 0.05).
CONCLUSION: This pilot study found that brief daily meditation practices by family dementia caregivers can lead to improved mental and cognitive functioning and lower levels of depressive symptoms. This improvement is accompanied by an increase in telomerase activity suggesting improvement in stress-induced cellular aging. These results need to be confirmed in a larger sample.
|Alternate Journal||Int J Geriatr Psychiatry|
|PubMed Central ID||PMC3423469|
|Grant List||AG 026364 / AG / NIA NIH HHS / United States |
AT003480 / AT / NCCIH NIH HHS / United States
CA 10014152 / CA / NCI NIH HHS / United States
CA116778 / CA / NCI NIH HHS / United States
HL 079955 / HL / NHLBI NIH HHS / United States
K24 MH086481 / MH / NIMH NIH HHS / United States
MH077650 / MH / NIMH NIH HHS / United States
MH086481 / MH / NIMH NIH HHS / United States
P30 AG028748 / AG / NIA NIH HHS / United States
P30-AG028748 / AG / NIA NIH HHS / United States
R21 AT003480 / AT / NCCIH NIH HHS / United States
RR00827 / RR / NCRR NIH HHS / United States
T32-MH19925 / MH / NIMH NIH HHS / United States
UL1 TR000124 / TR / NCATS NIH HHS / United States