Neuroimmunology of disordered sleep in depression and alcoholism.
|Title||Neuroimmunology of disordered sleep in depression and alcoholism.|
|Publication Type||Journal Article|
|Year of Publication||2001|
|Date Published||2001 Nov|
|Keywords||Alcoholism, Cytokines, Depressive Disorder, Humans, Immunity, Killer Cells, Natural, Sleep Wake Disorders|
The specific functions of sleep are not known, although sleep is commonly considered a restorative process that is important for the proper functioning of the immune system. Severity of disordered sleep in depressed and alcoholic subjects correlates with declines in natural and cellular immunity and is associated with alterations in the complex cytokine network. Despite evidence that sleep and sleep loss have effects on immune processes and nocturnal secretion of cytokines, the physiological significance of these immune changes is not known. Moreover, in view of basic evidence of a reciprocal interaction between sleep and cytokines, further research is needed to understand whether alterations in cytokines contribute to disordered sleep.
|Grant List||2P30-MH30914 / MH / NIMH NIH HHS / United States |
5T32-18399 / / PHS HHS / United States
AA10215 / AA / NIAAA NIH HHS / United States
M01 RR00827 / RR / NCRR NIH HHS / United States