Neuroimmunology of disordered sleep in depression and alcoholism.

TitleNeuroimmunology of disordered sleep in depression and alcoholism.
Publication TypeJournal Article
Year of Publication2001
AuthorsIrwin M
Issue5 Suppl
Date Published2001 Nov
KeywordsAlcoholism, Cytokines, Depressive Disorder, Humans, Immunity, Killer Cells, Natural, Sleep Wake Disorders

The specific functions of sleep are not known, although sleep is commonly considered a restorative process that is important for the proper functioning of the immune system. Severity of disordered sleep in depressed and alcoholic subjects correlates with declines in natural and cellular immunity and is associated with alterations in the complex cytokine network. Despite evidence that sleep and sleep loss have effects on immune processes and nocturnal secretion of cytokines, the physiological significance of these immune changes is not known. Moreover, in view of basic evidence of a reciprocal interaction between sleep and cytokines, further research is needed to understand whether alterations in cytokines contribute to disordered sleep.

Alternate JournalNeuropsychopharmacology
PubMed ID11682273
Grant List2P30-MH30914 / MH / NIMH NIH HHS / United States
5T32-18399 / / PHS HHS / United States
AA10215 / AA / NIAAA NIH HHS / United States
M01 RR00827 / RR / NCRR NIH HHS / United States