Nervous system regulation of the cancer genome.
Title | Nervous system regulation of the cancer genome. |
Publication Type | Journal Article |
Year of Publication | 2013 |
Authors | Cole SW |
Journal | Brain Behav Immun |
Volume | 30 Suppl |
Pagination | S10-8 |
Date Published | 2013 Mar |
ISSN | 1090-2139 |
Keywords | Animals, Gene Expression Regulation, Neoplastic, Humans, Neoplasms, Nervous System, Signal Transduction, Transcriptome, Tumor Microenvironment |
Abstract | Genomics-based analyses have provided deep insight into the basic biology of cancer and are now clarifying the molecular pathways by which psychological and social factors can regulate tumor cell gene expression and genome evolution. This review summarizes basic and clinical research on neural and endocrine regulation of the cancer genome and its interactions with the surrounding tumor microenvironment, including the specific types of genes subject to neural and endocrine regulation, the signal transduction pathways that mediate such effects, and therapeutic approaches that might be deployed to mitigate their impact. Beta-adrenergic signaling from the sympathetic nervous system has been found to up-regulated a diverse array of genes that contribute to tumor progression and metastasis, whereas glucocorticoid-regulated genes can inhibit DNA repair and promote cancer cell survival and resistance to chemotherapy. Relationships between socio-environmental risk factors, neural and endocrine signaling to the tumor microenvironment, and transcriptional responses by cancer cells and surrounding stromal cells are providing new mechanistic insights into the social epidemiology of cancer, new therapeutic approaches for protecting the health of cancer patients, and new molecular biomarkers for assessing the impact of behavioral and pharmacologic interventions. |
DOI | 10.1016/j.bbi.2012.11.008 |
Alternate Journal | Brain Behav. Immun. |
PubMed ID | 23207104 |
PubMed Central ID | PMC3600385 |
Grant List | R01 CA116778 / CA / NCI NIH HHS / United States R01-CA116778 / CA / NCI NIH HHS / United States |