Nervous system regulation of the cancer genome.

TitleNervous system regulation of the cancer genome.
Publication TypeJournal Article
Year of Publication2013
AuthorsCole SW
JournalBrain Behav Immun
Volume30 Suppl
Date Published2013 Mar
KeywordsAnimals, Gene Expression Regulation, Neoplastic, Humans, Neoplasms, Nervous System, Signal Transduction, Transcriptome, Tumor Microenvironment

Genomics-based analyses have provided deep insight into the basic biology of cancer and are now clarifying the molecular pathways by which psychological and social factors can regulate tumor cell gene expression and genome evolution. This review summarizes basic and clinical research on neural and endocrine regulation of the cancer genome and its interactions with the surrounding tumor microenvironment, including the specific types of genes subject to neural and endocrine regulation, the signal transduction pathways that mediate such effects, and therapeutic approaches that might be deployed to mitigate their impact. Beta-adrenergic signaling from the sympathetic nervous system has been found to up-regulated a diverse array of genes that contribute to tumor progression and metastasis, whereas glucocorticoid-regulated genes can inhibit DNA repair and promote cancer cell survival and resistance to chemotherapy. Relationships between socio-environmental risk factors, neural and endocrine signaling to the tumor microenvironment, and transcriptional responses by cancer cells and surrounding stromal cells are providing new mechanistic insights into the social epidemiology of cancer, new therapeutic approaches for protecting the health of cancer patients, and new molecular biomarkers for assessing the impact of behavioral and pharmacologic interventions.

Alternate JournalBrain Behav. Immun.
PubMed ID23207104
PubMed Central IDPMC3600385
Grant ListR01 CA116778 / CA / NCI NIH HHS / United States
R01-CA116778 / CA / NCI NIH HHS / United States