Negative and competitive social interactions are related to heightened proinflammatory cytokine activity.
|Title||Negative and competitive social interactions are related to heightened proinflammatory cytokine activity.|
|Publication Type||Journal Article|
|Year of Publication||2012|
|Authors||Chiang JJ, Eisenberger NI, Seeman TE, Taylor SE|
|Journal||Proc Natl Acad Sci U S A|
|Date Published||2012 Feb 7|
|Keywords||Adult, Competitive Behavior, Continental Population Groups, Cytokines, Female, Humans, Inflammation Mediators, Interpersonal Relations, Male, Stress, Psychological|
Research has consistently documented that social relationships influence physical health, a link that may implicate systemic inflammation. We examined whether daily social interactions predict levels of proinflammatory cytokines IL-6 and the soluble receptor for tumor necrosis factor-α (sTNFαRII) and their reactivity to a social stressor. One-hundred twenty-two healthy young adults completed daily diaries for 8 d that assessed positive, negative, and competitive social interactions. Participants then engaged in laboratory stress challenges, and IL-6 and sTNFαRII were collected at baseline and at 25- and 80-min poststressor, from oral mucosal transudate. Negative social interactions predicted elevated sTNFαRII at baseline, and IL-6 and sTNFαRII 25-min poststressor, as well as total output of sTNFαRII. Competitive social interactions predicted elevated baseline levels of IL-6 and sTNFαRII and total output of both cytokines. These findings suggest that daily social interactions that are negative and competitive are associated prospectively with heightened proinflammatory cytokine activity.
|Alternate Journal||Proc. Natl. Acad. Sci. U.S.A.|
|PubMed Central ID||PMC3277534|
|Grant List||AG030309 / AG / NIA NIH HHS / United States|