Mindfulness meditation for younger breast cancer survivors: a randomized controlled trial.

TitleMindfulness meditation for younger breast cancer survivors: a randomized controlled trial.
Publication TypeJournal Article
Year of Publication2015
AuthorsBower JE, Crosswell AD, Stanton AL, Crespi CM, Winston D, Arevalo J, Ma J, Cole SW, Ganz PA
Date Published2015 Apr 15
KeywordsAdult, Biomarkers, Tumor, Breast Neoplasms, Case-Control Studies, Female, Humans, Inflammation, Meditation, Middle Aged, Mindfulness, Surveys and Questionnaires, Survivors, Treatment Outcome

BACKGROUND: Premenopausal women diagnosed with breast cancer are at risk for psychological and behavioral disturbances after cancer treatment. Targeted interventions are needed to address the needs of this vulnerable group.

METHODS: This randomized trial provided the first evaluation of a brief, mindfulness-based intervention for younger breast cancer survivors designed to reduce stress, depression, and inflammatory activity. Women diagnosed with early stage breast cancer at or before age 50 who had completed cancer treatment were randomly assigned to a 6-week Mindful Awareness Practices (MAPS) intervention group (n = 39) or to a wait-list control group (n = 32). Participants completed questionnaires before and after the intervention to assess stress and depressive symptoms (primary outcomes) as well as physical symptoms, cancer-related distress, and positive outcomes. Blood samples were collected to examine genomic and circulating markers of inflammation. Participants also completed questionnaires at a 3-month follow-up assessment.

RESULTS: In linear mixed models, the MAPS intervention led to significant reductions in perceived stress (P = .004) and marginal reductions in depressive symptoms (P = .094), as well as significant reductions in proinflammatory gene expression (P = .009) and inflammatory signaling (P = .001) at postintervention. Improvements in secondary outcomes included reduced fatigue, sleep disturbance, and vasomotor symptoms and increased peace and meaning and positive affect (P < .05 for all). Intervention effects on psychological and behavioral measures were not maintained at the 3-month follow-up assessment, although reductions in cancer-related distress were observed at that assessment.

CONCLUSIONS: A brief, mindfulness-based intervention demonstrated preliminary short-term efficacy in reducing stress, behavioral symptoms, and proinflammatory signaling in younger breast cancer survivors.

Alternate JournalCancer
PubMed ID25537522
PubMed Central IDPMC4393338
Grant ListCA 16042 / CA / NCI NIH HHS / United States
P30 CA016042 / CA / NCI NIH HHS / United States
T32 GM084903 / GM / NIGMS NIH HHS / United States
T32AG033533 / AG / NIA NIH HHS / United States
T32GM084903 / GM / NIGMS NIH HHS / United States