Interleukin-6 and memory functions of encoding and recall in healthy and depressed elderly adults.
Title | Interleukin-6 and memory functions of encoding and recall in healthy and depressed elderly adults. |
Publication Type | Journal Article |
Year of Publication | 2012 |
Authors | Elderkin-Thompson V, Irwin MR, Hellemann G, Kumar A |
Journal | Am J Geriatr Psychiatry |
Volume | 20 |
Issue | 9 |
Pagination | 753-63 |
Date Published | 2012 Sep |
ISSN | 1545-7214 |
Keywords | Age Factors, Aged, Attention, C-Reactive Protein, Depression, Executive Function, Female, Humans, Interleukin-6, Male, Mental Recall, Neuropsychological Tests, Psychiatric Status Rating Scales, Retention (Psychology), Sex Characteristics |
Abstract | Activation of proinflammatory cytokines is associated with depressed mood, feelings of fatigue, and changes in cognitive function. This study examined the relationships between cognitive performance and circulating cellular markers of inflammation, interleukin-6 (IL-6) and C-reactive protein (CRP), in moderately depressed and comparison healthy older adults. We conducted a cross-sectional analysis of 87 volunteers (45 nondepressed and 42 depressed) in which participants completed the Structured Clinical Diagnostic Interview and were evaluated by a geriatric psychiatrist for dementia, depression, stroke risk, and neurologic disorders. Volunteers also completed an electrocardiogram, standard battery of laboratory tests, and neuropsychological examination that assessed memory functions of Encoding and Recall, Executive Function, and Attention/Processing. Mid-morning IL-6 and CRP levels were assessed. The data analysis showed that Encoding and Recall were inversely associated with IL-6 across diagnostic groups after controlling for chronological age, Mini-Mental State Examination, body mass index, literacy level, depression severity, and sex. CRP was not associated with cognition. Depression status was associated with recall independent of IL-6 levels. In conclusion, IL-6 serum levels among elderly individuals is a significant correlate of memory performance. Women, in particular, appear sensitive to IL-6 fluctuations across diagnostic groups. |
DOI | 10.1097/JGP.0b013e31825d08d6 |
Alternate Journal | Am J Geriatr Psychiatry |
PubMed ID | 22892560 |
PubMed Central ID | PMC3690956 |
Grant List | 2R01 MH063764-05A2 / MH / NIMH NIH HHS / United States AG 026364 / AG / NIA NIH HHS / United States CA 10014152 / CA / NCI NIH HHS / United States CA116778 / CA / NCI NIH HHS / United States HL 079955 / HL / NHLBI NIH HHS / United States MO1 RR00865 / RR / NCRR NIH HHS / United States P30 AG028748 / AG / NIA NIH HHS / United States P30 AG028748 / AG / NIA NIH HHS / United States R01 AG026364 / AG / NIA NIH HHS / United States R01 AG034588 / AG / NIA NIH HHS / United States R01 CA119159 / CA / NCI NIH HHS / United States R01 CA160245 / CA / NCI NIH HHS / United States R01 MH 63764 / MH / NIMH NIH HHS / United States R01 MH063764 / MH / NIMH NIH HHS / United States UL1 TR000124 / TR / NCATS NIH HHS / United States |