An evaluation of a biopsychosocial framework for health-related quality of life and disability in rheumatoid arthritis.
|Title||An evaluation of a biopsychosocial framework for health-related quality of life and disability in rheumatoid arthritis.|
|Publication Type||Journal Article|
|Year of Publication||2011|
|Authors||Nicassio PM, Kay MA, Custodio MK, Irwin MR, Olmstead R, Weisman MH|
|Journal||J Psychosom Res|
|Date Published||2011 Aug|
|Keywords||Adaptation, Psychological, Adult, Aged, Arthritis, Rheumatoid, Disability Evaluation, Disabled Persons, Female, Health Status, Humans, Male, Middle Aged, Models, Psychological, Quality of Life, Severity of Illness Index|
OBJECTIVE: To examine the relationships between physical, psychological, and social factors and health-related quality of life (HRQOL) and disability in rheumatoid arthritis (RA).
METHODS: A sample of 106 patients with rheumatoid arthritis (RA) completed measures of self-reported disease activity and psychosocial functioning, including coping, personal mastery, social network, perceived stress, illness beliefs, the SF-36 and Health Assessment Questionnaire Disability Index (HAQ-DI). In addition, physician-based assessment of disease activity using the Disease Activity Scale (DAS-28) was obtained. Hierarchical multiple regression analyses were used to evaluate the relationships between psychosocial factors and scores on the SF-36 and HAQ-DI.
RESULTS: Lower self-reported disease activity was associated with higher SF-36 physical functioning scores, while the contribution of active coping, passive coping, and helplessness was significant only as a block. Lower self-reported disease activity, higher personal mastery, and lower perceived stress contributed to higher SF-36 mental health functioning, and higher self-reported disease activity and lower helplessness were associated with greater disability, as indexed by the HAQ-DI. The DAS-28, an objective of measure of disease activity, was unrelated to any of these outcomes.
CONCLUSIONS: The findings highlight the importance of targeting psychological factors to enhance HRQOL and disability in the clinical management of RA patients.
|Alternate Journal||J Psychosom Res|
|PubMed Central ID||PMC3139906|
|Grant List||AG026364 / AG / NIA NIH HHS / United States |
AG034588 / AG / NIA NIH HHS / United States
AR R01-049840 / AR / NIAMS NIH HHS / United States
CA119159 / CA / NCI NIH HHS / United States
DA 027558 / DA / NIDA NIH HHS / United States
HL 079955 / HL / NHLBI NIH HHS / United States
P30 AG028748 / AG / NIA NIH HHS / United States
P30-AG028748 / AG / NIA NIH HHS / United States
R01 AR049840 / AR / NIAMS NIH HHS / United States
R01 AR049840-01 / AR / NIAMS NIH HHS / United States
RR00827 / RR / NCRR NIH HHS / United States
T32-MH19925 / MH / NIMH NIH HHS / United States
UL1 RR033176 / RR / NCRR NIH HHS / United States
UL1 TR000124 / TR / NCATS NIH HHS / United States