Effects of sleep and sleep loss on immunity and cytokines.

TitleEffects of sleep and sleep loss on immunity and cytokines.
Publication TypeJournal Article
Year of Publication2002
AuthorsIrwin M
JournalBrain Behav Immun
Date Published2002 Oct
KeywordsAlcoholism, Cytokines, Depressive Disorder, Humans, Sleep, Sleep Deprivation, Sleep Initiation and Maintenance Disorders, Sleep Stages

Sleep is hypothesized to be a restorative process that is important for the proper functioning of the immune system. Severity of disordered sleep in depressed- and alcoholic subjects correlates with declines in natural- and cellular immunity and is associated with alterations in the complex cytokine network. Sleep loss has a role in mediating these immune changes as experimentally induced partial night sleep deprivation replicates the kind of sleep loss found in clinical samples and induces a pattern of immune alterations similar to that found in depressed- and alcoholic patients. Despite evidence that sleep and sleep loss have effects on immune processes and nocturnal secretion of cytokines, the clinical significance of these immune changes is not known. Moreover, in view of basic evidence of a reciprocal interaction between sleep and cytokines, further research is needed to understand whether alterations in cytokines contribute to disordered sleep in patient populations.

Alternate JournalBrain Behav. Immun.
PubMed ID12401464
Grant List2P30-MH30914 / MH / NIMH NIH HHS / United States
5T32-18399 / / PHS HHS / United States
AA10215 / AA / NIAAA NIH HHS / United States
AA13239 / AA / NIAAA NIH HHS / United States
M01 RR00827 / RR / NCRR NIH HHS / United States
MH55253 / MH / NIMH NIH HHS / United States