The effects of mind-body therapies on the immune system: meta-analysis.
|Title||The effects of mind-body therapies on the immune system: meta-analysis.|
|Publication Type||Journal Article|
|Year of Publication||2014|
|Authors||Morgan N, Irwin MR, Chung M, Wang C|
|Keywords||C-Reactive Protein, CD4 Lymphocyte Count, Humans, Inflammation, Interleukin-6, MEDLINE, Randomized Controlled Trials as Topic, Tai Ji, Tumor Necrosis Factor-alpha, Virus Diseases|
IMPORTANCE: Psychological and health-restorative benefits of mind-body therapies have been investigated, but their impact on the immune system remain less defined.
OBJECTIVE: To conduct the first comprehensive review of available controlled trial evidence to evaluate the effects of mind-body therapies on the immune system, focusing on markers of inflammation and anti-viral related immune responses.
METHODS: Data sources included MEDLINE, CINAHL, SPORTDiscus, and PsycINFO through September 1, 2013. Randomized controlled trials published in English evaluating at least four weeks of Tai Chi, Qi Gong, meditation, or Yoga that reported immune outcome measures were selected. Studies were synthesized separately by inflammatory (n = 18), anti-viral related immunity (n = 7), and enumerative (n = 14) outcomes measures. We performed random-effects meta-analyses using standardized mean difference when appropriate.
RESULTS: Thirty-four studies published in 39 articles (total 2, 219 participants) met inclusion criteria. For inflammatory measures, after 7 to 16 weeks of mind-body intervention, there was a moderate effect on reduction of C-reactive protein (effect size [ES], 0.58; 95% confidence interval [CI], 0.04 to 1.12), a small but not statistically significant reduction of interleukin-6 (ES, 0.35; 95% CI, -0.04 to 0.75), and negligible effect on tumor necrosis factor-α (ES, 0.21; 95% CI, -0.15 to 0.58). For anti-viral related immune and enumerative measures, there were negligible effects on CD4 counts (ES, 0.15; 95% CI, -0.04 to 0.34) and natural killer cell counts (ES, 0.12, 95% CI -0.21 to 0.45). Some evidence indicated mind-body therapies increase immune responses to vaccination.
CONCLUSIONS: Mind-body therapies reduce markers of inflammation and influence virus-specific immune responses to vaccination despite minimal evidence suggesting effects on resting anti-viral or enumerative measures. These immunomodulatory effects, albeit incomplete, warrant further methodologically rigorous studies to determine the clinical implications of these findings for inflammatory and infectious disease outcomes.
|Alternate Journal||PLoS ONE|
|PubMed Central ID||PMC4079606|
|Grant List||K24 AT007323 / AT / NCCIH NIH HHS / United States |
K24 AT007323 / AT / NCCIH NIH HHS / United States
P30 AG028748 / AG / NIA NIH HHS / United States
P30-AG028748 / AG / NIA NIH HHS / United States
R01 AT005521 / AT / NCCIH NIH HHS / United States
R01 AT006367 / AT / NCCIH NIH HHS / United States
R01 AT006367-01A1 / AT / NCCIH NIH HHS / United States
R01 CA160245-01 / CA / NCI NIH HHS / United States
R01 DA032922-01 / DA / NIDA NIH HHS / United States
R01 HL095799 / HL / NHLBI NIH HHS / United States
R01-AG026364 / AG / NIA NIH HHS / United States
R01-AG034588 / AG / NIA NIH HHS / United States
R01-CA119159 / CA / NCI NIH HHS / United States
UL1TR000124 / TR / NCATS NIH HHS / United States