Depression and immunity: inflammation and depressive symptoms in multiple sclerosis.

TitleDepression and immunity: inflammation and depressive symptoms in multiple sclerosis.
Publication TypeJournal Article
Year of Publication2009
AuthorsGold SM, Irwin MR
JournalImmunol Allergy Clin North Am
Volume29
Issue2
Pagination309-20
Date Published2009 May
ISSN1557-8607
KeywordsDepression, Humans, Inflammation, Multiple Sclerosis
Abstract

An increasing body of evidence suggests that patients who have major depressive disorder show alterations in immunologic markers including increases in proinflammatory cytokine activity and inflammation. Inflammation of the central nervous system is a pathologic hallmark of multiple sclerosis (MS). Patients affected by this disease also show a high incidence of depression. Accumulating evidence from animal studies suggests that some aspects of depression and fatigue in MS may be linked to inflammatory markers. This article reviews the current knowledge in the field and illustrates how the sickness behavior model may be applied to investigate depressive symptoms in inflammatory neurologic diseases.

DOI10.1016/j.iac.2009.02.008
Alternate JournalImmunol Allergy Clin North Am
PubMed ID19389584
PubMed Central IDPMC3625861
Grant ListAG18367 / AG / NIA NIH HHS / United States
M01 RR00827 / RR / NCRR NIH HHS / United States
MH55253 / MH / NIMH NIH HHS / United States
R01 AG018367 / AG / NIA NIH HHS / United States
R01 AG026364 / AG / NIA NIH HHS / United States
R01 MH055253 / MH / NIMH NIH HHS / United States
T32 MH019925 / MH / NIMH NIH HHS / United States
T32-MH19925 / MH / NIMH NIH HHS / United States