Depression and immunity: inflammation and depressive symptoms in multiple sclerosis.
Title | Depression and immunity: inflammation and depressive symptoms in multiple sclerosis. |
Publication Type | Journal Article |
Year of Publication | 2009 |
Authors | Gold SM, Irwin MR |
Journal | Immunol Allergy Clin North Am |
Volume | 29 |
Issue | 2 |
Pagination | 309-20 |
Date Published | 2009 May |
ISSN | 1557-8607 |
Keywords | Depression, Humans, Inflammation, Multiple Sclerosis |
Abstract | An increasing body of evidence suggests that patients who have major depressive disorder show alterations in immunologic markers including increases in proinflammatory cytokine activity and inflammation. Inflammation of the central nervous system is a pathologic hallmark of multiple sclerosis (MS). Patients affected by this disease also show a high incidence of depression. Accumulating evidence from animal studies suggests that some aspects of depression and fatigue in MS may be linked to inflammatory markers. This article reviews the current knowledge in the field and illustrates how the sickness behavior model may be applied to investigate depressive symptoms in inflammatory neurologic diseases. |
DOI | 10.1016/j.iac.2009.02.008 |
Alternate Journal | Immunol Allergy Clin North Am |
PubMed ID | 19389584 |
PubMed Central ID | PMC3625861 |
Grant List | AG18367 / AG / NIA NIH HHS / United States M01 RR00827 / RR / NCRR NIH HHS / United States MH55253 / MH / NIMH NIH HHS / United States R01 AG018367 / AG / NIA NIH HHS / United States R01 AG026364 / AG / NIA NIH HHS / United States R01 MH055253 / MH / NIMH NIH HHS / United States T32 MH019925 / MH / NIMH NIH HHS / United States T32-MH19925 / MH / NIMH NIH HHS / United States |