Characterizing biased cancer-related cognitive processing: relationships with BRCA1/2 genetic mutation status, personal cancer history, age, and prophylactic surgery.
|Title||Characterizing biased cancer-related cognitive processing: relationships with BRCA1/2 genetic mutation status, personal cancer history, age, and prophylactic surgery.|
|Publication Type||Journal Article|
|Year of Publication||2014|
|Authors||Carpenter KM, Eisenberg S, Weltfreid S, Low CA, Beran T, Stanton AL|
|Date Published||2014 Sep|
|Keywords||Adult, Age Distribution, Aged, Attitude to Health, Breast Neoplasms, Cognition, Decision Making, Female, Forecasting, Genes, BRCA1, Genes, BRCA2, Genetic Predisposition to Disease, Genetic Testing, Humans, Linear Models, Logistic Models, Los Angeles, Mastectomy, Middle Aged, Mutation, Ovarian Neoplasms, Ovariectomy, Reaction Time, Risk Assessment, Stroop Test|
OBJECTIVE: This study evaluated associations of cancer-related cognitive processing with BRCA1/2 mutation carrier status, personal cancer history, age, and election of prophylactic surgery in women at high risk for breast cancer.
METHOD: In a 2 (BRCA1/2 mutation carrier status) × 2 (personal cancer history) matched-control design, with age as an additional predictor, participants (N = 115) completed a computerized cancer Stroop task. Dependent variables were response latency to cancer-related stimuli (reaction time [RT]) and cancer-related cognitive interference (cancer RT minus neutral RT). RT and interference were tested as predictors of prophylactic surgery in the subsequent four years.
RESULTS: RT for cancer-related words was significantly slower than other word groups, indicating biased processing specific to cancer-related stimuli. Participants with a cancer history evidenced longer RT to cancer-related words than those without a history; moreover, a significant Cancer History × Age interaction indicated that, among participants with a cancer history, the typical advantage associated with younger age on Stroop tasks was absent. BRCA mutation carriers demonstrated more cancer-related cognitive interference than noncarriers. Again, the typical Stroop age advantage was absent among carriers. Exploratory analyses indicated that BRCA+ status and greater cognitive interference predicted greater likelihood of undergoing prophylactic surgery. Post hoc tests suggest that cancer-related distress does not account for these relationships.
CONCLUSIONS: In the genetic testing context, younger women with a personal cancer history or who are BRCA1/2 mutation carriers might be particularly vulnerable to biases in cancer-related cognitive processing. Biased processing was associated marginally with greater likelihood of prophylactic surgery.
|Alternate Journal||Health Psychol|
|Grant List||P30 CA16042 / CA / NCI NIH HHS / United States |
R25 CA087949 / CA / NCI NIH HHS / United States