Catecholamine predictors of complicated grief treatment outcomes.

TitleCatecholamine predictors of complicated grief treatment outcomes.
Publication TypeJournal Article
Year of Publication2013
AuthorsO'Connor M-F, M Shear K, Fox R, Skritskaya N, Campbell B, Ghesquiere A, Glickman K
JournalInt J Psychophysiol
Date Published2013 Jun
KeywordsAged, Biomarkers, Catecholamines, Female, Grief, Humans, Interpersonal Relations, Male, Middle Aged, Psychotherapy, Treatment Outcome

Could sympathetic hyperarousal limit treatment success in complicated grief? The present study investigated persons with complicated grief, a chronic condition with distinct symptoms including persistent intense yearning and longing for the person who died, avoidance of reminders that the person is gone, deep relentless sadness, self-blame, bitterness, or anger in connection with the death, and an inability to gain satisfaction or joy through engaging in meaningful activities or relationships with significant others. Length of bereavement did not correlate with complicated grief scores. Catecholamines (i.e., epinephrine, norepinephrine, dopamine) in plasma were assessed pre- and post-psychotherapeutic treatment. Participants with the highest levels of epinephrine at pre-treatment had the highest levels of complicated grief symptoms at post-treatment, accounting for baseline levels of symptoms. This predictive relationship was not seen for depressive symptoms. The present study supports the hypothesis that catecholamine levels are affected by bereavement, and in turn, can affect the ability of those with complicated grief to benefit from psychotherapy.

Alternate JournalInt J Psychophysiol
PubMed ID23044089
PubMed Central IDPMC3664660
Grant List5P30AG028748 / AG / NIA NIH HHS / United States
AG028404 / AG / NIA NIH HHS / United States
K01 AG028404 / AG / NIA NIH HHS / United States
MH60741 / MH / NIMH NIH HHS / United States
P30 AG028748 / AG / NIA NIH HHS / United States
R01 MH060783 / MH / NIMH NIH HHS / United States