Cancer-related fatigue--mechanisms, risk factors, and treatments.

TitleCancer-related fatigue--mechanisms, risk factors, and treatments.
Publication TypeJournal Article
Year of Publication2014
AuthorsBower JE
JournalNat Rev Clin Oncol
Date Published2014 Oct
KeywordsFatigue, Humans, Inflammation, Longitudinal Studies, Neoplasms, Quality of Life, Randomized Controlled Trials as Topic, Risk Factors, Survivors

Fatigue is one of the most common adverse effects of cancer that might persist for years after treatment completion in otherwise healthy survivors. Cancer-related fatigue causes disruption in all aspects of quality of life and might be a risk factor of reduced survival. The prevalence and course of fatigue in patients with cancer have been well characterized and there is growing understanding of the underlying biological mechanisms. Inflammation seems to have a key role in fatigue before, during, and after cancer-treatment. However, there is a considerable variability in the presentation of cancer-related fatigue, much of which is not explained by disease-related or treatment-related characteristics, suggesting that host factors might be important in the development and persistence of this symptom. Indeed, longitudinal studies have identified genetic, biological, psychosocial, and behavioural risk factors associated with cancer-related fatigue. Although no current gold-standard treatment for fatigue is available, a variety of intervention approaches have shown beneficial effects in randomized controlled trials, including physical activity, psychosocial, mind-body, and pharmacological treatments. This Review describes the mechanisms, risk factors, and possible interventions for cancer-related fatigue, focusing on recent longitudinal studies and randomized trials that have targeted fatigued patients.

Alternate JournalNat Rev Clin Oncol
PubMed ID25113839
PubMed Central IDPMC4664449
Grant List5R01CA160427 / CA / NCI NIH HHS / United States
R01 CA160427 / CA / NCI NIH HHS / United States