Association of C-reactive protein and interleukin-6 with new-onset fatigue in the Whitehall II prospective cohort study.
|Title||Association of C-reactive protein and interleukin-6 with new-onset fatigue in the Whitehall II prospective cohort study.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Cho HJ, Kivimäki M, Bower JE, Irwin MR|
|Date Published||2013 Aug|
|Keywords||Adult, Biomarkers, C-Reactive Protein, Cross-Sectional Studies, Fatigue, Fatigue Syndrome, Chronic, Female, Humans, Inflammation Mediators, Interleukin-6, London, Male, Middle Aged, Prospective Studies|
BACKGROUND: Although basic research on neuroimmune interactions suggests that inflammatory processes may play a role in the development of fatigue, population-based evidence on this association is limited. This study examined whether plasma C-reactive protein (CRP) and interleukin-6 (IL-6), biomarkers of systemic inflammation, predict fatigue onset.
METHOD: The Whitehall II study is a large-scale cohort study conducted in 20 civil service departments in London. Plasma CRP and IL-6 were measured in 4847 non-fatigued participants at phase 3 (1991-1993, aged 39-63 years). Fatigue was assessed using the Vitality subscale of the 36-item Short Form Health Survey (SF-36) at phase 3 and phase 4 (1995-1996).
RESULTS: During a mean follow-up of 3.1 years, 957 new fatigue cases (19.7%) were identified using the pre-established cut-off score of ≤ 50 on the Vitality subscale. CRP values were dichotomized as low (<1.0 mg/l ) or high (≥ 1.0 mg/l) using the Centers for Disease Control/American Heart Association recommendations. Similarly, IL-6 values were also dichotomized as low (<1.5 pg/ml) or high (≥ 1.5 pg/ml). After full adjustment for sociodemographic and biobehavioral covariates, the odds ratios for new-onset fatigue were 1.28 [95% confidence interval (CI) 1.09-1.49, p = 0.003] for high CRP and 1.24 (95% CI 1.06-1.45, p = 0.008) for high IL-6. Similar results were found when CRP and IL-6 were treated as continuous variables.
CONCLUSIONS: Plasma CRP and IL-6 were prospectively associated with new-onset fatigue, supporting the hypothesis that low-grade inflammation has a role in the development of fatigue.
|Alternate Journal||Psychol Med|
|PubMed Central ID||PMC3819455|
|Grant List||AG13196 / AG / NIA NIH HHS / United States |
HL36310 / HL / NHLBI NIH HHS / United States
HS06516 / HS / AHRQ HHS / United States
P30 AG028748 / AG / NIA NIH HHS / United States
P30-AG028748 / AG / NIA NIH HHS / United States
PG/11/63/29011 / / British Heart Foundation / United Kingdom
R01 AG013196 / AG / NIA NIH HHS / United States
R01 HL036310 / HL / NHLBI NIH HHS / United States
R01-AG026364 / AG / NIA NIH HHS / United States
R01-AG034588 / AG / NIA NIH HHS / United States
R01-CA119159 / CA / NCI NIH HHS / United States
R01-HL079955 / HL / NHLBI NIH HHS / United States
R01-MH091352 / MH / NIMH NIH HHS / United States
RG/13/2/30098 / / British Heart Foundation / United Kingdom
UL1 TR000124 / TR / NCATS NIH HHS / United States
/ / British Heart Foundation / United Kingdom
/ / Department of Health / United Kingdom
/ / Medical Research Council / United Kingdom