The association between major depression and levels of soluble intercellular adhesion molecule 1, interleukin-6, and C-reactive protein in patients with recent acute coronary syndromes.
|Title||The association between major depression and levels of soluble intercellular adhesion molecule 1, interleukin-6, and C-reactive protein in patients with recent acute coronary syndromes.|
|Publication Type||Journal Article|
|Year of Publication||2004|
|Authors||Lespérance F, Frasure-Smith N, Théroux P, Irwin M|
|Journal||Am J Psychiatry|
|Date Published||2004 Feb|
|Keywords||Acute Disease, Adult, Aged, Aged, 80 and over, Body Mass Index, C-Reactive Protein, Comorbidity, Coronary Disease, Depressive Disorder, Major, Female, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Intercellular Adhesion Molecule-1, Interleukin-6, Male, Middle Aged, Obesity, Prevalence|
OBJECTIVE: This study was conducted to determine whether or not depression is associated with higher levels of inflammatory markers in patients recovering from acute coronary syndromes.
METHOD: Plasma levels of soluble intercellular adhesion molecule 1 (sICAM-1) and interleukin-6 (IL-6) and the serum level of C-reactive protein were measured in 481 patients 2 months after hospitalization for acute coronary syndromes. Diagnosis of major depression was based on the Structured Clinical Interview for DSM-IV.
RESULTS: Depressed patients showed significantly higher sICAM-1 levels, a difference that remained significant after adjustment for potential confounders (gender, smoking, presence of metabolic syndrome). Although there was no significant association between depression and IL-6, there was an interaction between depression and statin therapy for levels of C-reactive protein. Depressed patients not taking statins had markedly higher C-reactive protein levels than did nondepressed patients. There was no relationship with depression in those receiving statins.
CONCLUSIONS: These results suggest chronic endothelial activation among depressed patients after acute coronary syndromes. Further research is needed to determine whether or not higher levels of sICAM-1 may identify a subgroup of depressed patients at particularly high risk for cardiac events among patients with established coronary artery disease or among those without previous coronary artery disease.
|Alternate Journal||Am J Psychiatry|
|Grant List||MH-55253 / MH / NIMH NIH HHS / United States|