New pathways and data on rapid eye movement sleep behaviour disorder in a rat model.
|Title||New pathways and data on rapid eye movement sleep behaviour disorder in a rat model.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Hsieh K-C, Nguyen D, Siegel JM, Lai Y-Y|
|Date Published||2013 Aug|
|Keywords||Animals, Baclofen, Brain Stem, Disease Models, Animal, Electroencephalography, Evoked Potentials, Auditory, GABA Antagonists, GABA-B Receptor Agonists, Inferior Colliculi, Male, Neural Pathways, Polysomnography, Rats, Rats, Sprague-Dawley, Receptors, GABA-B, REM Sleep Behavior Disorder, Sleep, REM|
OBJECTIVE: An abnormality in auditory evoked responses localised to the inferior colliculus (IC) has been reported in rapid eye movement (REM) sleep behaviour disorder (RBD) patients. The external cortex of the inferior colliculus (ICX) has been demonstrated not only to be involved in auditory processing, but also to participate in the modulation of motor activity.
METHODS: Rats were surgically implanted with electrodes for electroencephalography (EEG) and electromyography (EMG) recording and guide cannulae aimed at the ICX for drug infusions. Drug infusions were conducted after the animals recovered from surgery. Polysomnographic recordings with video were analysed to detect normal and abnormal sleep states.
RESULTS: Baclofen, a gamma-aminobutyric acid B (GABAB) receptor agonist, infused into the ICX increased phasic motor activity in slow-wave sleep (SWS) and REM sleep and tonic muscle activity in REM sleep; it also elicited RBD-like activity during the infusion and post-infusion period. In contrast, saclofen, a GABAB receptor antagonist, did not produce significant changes in motor activities in sleep. Baclofen infusions in ICX also significantly increased REM sleep during the post-infusion period, while saclofen infusions did not change the amount of any sleep-waking states.
CONCLUSIONS: This study suggests that GABAB receptor mechanisms in the ICX may be implicated in the pathology of RBD.
|Alternate Journal||Sleep Med.|
|PubMed Central ID||PMC3546264|
|Grant List||I01 BX001753 / BX / BLRD VA / United States |
NS14610 / NS / NINDS NIH HHS / United States
NS42566 / NS / NINDS NIH HHS / United States
R01 DA034748 / DA / NIDA NIH HHS / United States
R01 MH064109 / MH / NIMH NIH HHS / United States
R01 NS014610 / NS / NINDS NIH HHS / United States
R01 NS042566 / NS / NINDS NIH HHS / United States