Emotional acceptance, inflammation, and sickness symptoms across the first two years following breast cancer diagnosis.
|Title||Emotional acceptance, inflammation, and sickness symptoms across the first two years following breast cancer diagnosis.|
|Publication Type||Journal Article|
|Year of Publication||2016|
|Authors||Reed RG, Weihs KL, Sbarra DA, Breen EC, Irwin MR, Butler EA|
|Journal||Brain Behav Immun|
|Date Published||2016 Aug|
PURPOSE: Breast cancer diagnosis and treatment are associated with increased inflammatory activity, which can induce sickness symptoms. We examined whether emotional acceptance moderates the association between proinflammatory cytokines and self-reported sickness symptoms in women recently diagnosed with breast cancer.
METHODS: Women (N=136) diagnosed with stage 0-III breast cancer within the previous 6months provided plasma samples and completed the FACT: Physical Well-Being Scale, as well as the Acceptance of Emotion Scale every 3months for 2years. At each time point, we quantified interleukin (IL)-6, IL-8, IL-10, and tumor necrosis factor (TNF)-α using a high sensitivity multiplex assay.
RESULTS: Higher within-subject mean TNF-α across all time-points predicted higher mean sickness symptoms. At individual time-points, higher IL-6 and IL-8 levels were associated with higher sickness symptoms. Mean emotional acceptance across all time-points moderated the relationship between mean IL-8 and sickness symptoms, with sickness symptoms remaining persistently high in women with low emotional acceptance even when IL-8 levels were low. At individual time-points, emotional acceptance positively moderated the correlations of IL-8 and TNF-α with sickness symptoms, such that the associations between higher levels of these proinflammatory cytokines and higher sickness symptoms were attenuated when emotional acceptance was high.
CONCLUSION: Emotional acceptance was shown for the first time to moderate the associations of cytokines with sickness symptoms in breast cancer patients over time following diagnosis and treatment. The association between emotional acceptance and sickness symptoms was significantly different from zero but relatively small in comparison to the range of sickness symptoms. Results suggest that targeting emotion regulation may help to break the cycle between inflammation and sickness symptoms in women with breast cancer.
|Alternate Journal||Brain Behav. Immun.|
|PubMed Central ID||PMC4917434|
|Grant List||R01 CA133081 / CA / NCI NIH HHS / United States|