A biobehavioral perspective of tumor biology.

TitleA biobehavioral perspective of tumor biology.
Publication TypeJournal Article
Year of Publication2005
AuthorsMcDonald PGreen, Antoni MH, Lutgendorf SK, Cole SW, Dhabhar FS, Sephton SE, Stefanek M, Sood AK
JournalDiscov Med
Date Published2005 Dec

Extract: The perspective that cancer may be causally linked to stress has a long history. In 200 AD, Galen proposed that melancholic women were more susceptible to cancer than women who were sanguine. Rigorous examinations of related observations have lagged over the ensuing centuries. More recently, epidemiologic studies have shown that psychologic and social characteristics (e.g., chronic stress and negative life events, social isolation and support, socioeconomic burden, and emotional processes) might be associated with differential cancer incidence, progression, and mortality. The biologic mechanisms (e.g., signaling pathways) that may account for such observations are being discovered through the convergence of relevant molecular, cellular, and clinical data. In this article, we review the clinical and experimental evidence regarding the effects of stress on tumor development, growth, and progression. Within this context, we define "stress" as an external event ("stressor") or perception of such events that engender psychologic and physiologic changes ("stress responses") designed to approach, avoid, or defend against the external event.

Alternate JournalDiscov Med
PubMed ID20704834
PubMed Central IDPMC3144932
Grant ListR01 CA110793 / CA / NCI NIH HHS / United States
R01 CA110793-01 / CA / NCI NIH HHS / United States