Steven Cole

Steve Cole is an Associate Professor in the Division of Hematology-Oncology at the UCLA School of Medicine. After receiving his Ph.D. from Stanford University in 1993, Dr. Cole undertook 5 years of post-doctoral training in molecular virology at UCLA. His laboratory studies social regulation of gene expression and the biochemical signaling pathways involved. Much of this research focuses on viral genomes (HIV-1, KSHV) and the hormonal control of human gene expression dynamics. These studies take advantage of statistical bioinformatics tools developed by Dr. Cole to analyze the upstream control of gene expression by transcription factors and chromosomal alterations. Several of his software tools are in wide-spread use, including FOCUS (hypothesis-driven microarray analysis), GenomeScan (mapping chromosomal alterations from gene expression data), and TELiS (assessing transcription factor activity from gene expression data). His research has garnered a series of grants from the National Institutes of Health, nationwide media coverage on television, radio, newspapers, and the internet, and several scientific honors including Fellowship in the Academy of Behavioral Medicine research, the Cornelius Hoppers Young Investigator Award from the University of California AIDS Research Program, the George Miller Young Investigator Award from the Academy of Behavioral Medicine Research, Stanford's Centennial Teaching Award, the Daniel G. Aldrich Research Award at the University of California Santa Barbara, and served as an invited scholar and instructor at the Santa Fe Institute for Complex Systems. In addition to his primary appointment in the Department of Medicine, Dr. Cole is also a member of the Norman Cousins Center, the Jonsson Comprehensive Cancer Center, and the UCLA Molecular Biology Institute.

Mailing Address:	11-934 Factor Building UCLA School of Medicine Campus - 167817 Los Angeles, CA 90095 UNITED STATES
Work Address:	Office Factor Los Angeles, CA 90095 UNITED STATES
Work Address:	Laboratory Factor Los Angeles, CA 90095 UNITED STATES

Home Page:	http://www.cousinspni.org

Additional information

Contact details

Site:

Semel Institute/NPI

Faculty Details

DGSOM FDB ID:

45359

Primary Appointment:

Medicine

Secondary Appointment:

Psychiatry

Edit profile · Read full profile...

Research Interests

Steve Cole is an Assistant Professor in the Division of Hematology-Oncology at the UCLA School of Medicine. After receiving his Ph.D. from Stanford University in 1993, Dr. Cole undertook 5 years of post-doctoral training in molecular virology at UCLA. His laboratory studies social regulation of gene expression and the biochemical signaling pathways involved. Much of this research focuses on viral genomes (HIV-1, KSHV) and the hormonal control of human gene expression dynamics. These studies take advantage of statistical bioinformatics tools developed by Dr. Cole to analyze the ÃÂÃÂupstreamÃÂÃÂ control of gene expression by transcription factors and chromosomal alterations. Several of his software tools are in wide-spread use, including FOCUS (hypothesis-driven microarray analysis), GenomeScan (mapping chromosomal alterations from gene expression data), and TELiS (assessing transcription factor activity from gene expression data). His research has garnered a series of grants from the National Institutes of Health, nationwide media coverage on television, radio, newspapers, and the internet, and several scientific honors including the Cornelius Hoppers Young Investigator Award from the University of California AIDS Research Program, the George Miller Young Investigator Award from the Academy of Behavioral Medicine Research, StanfordÃÂÃÂs Centennial Teaching Award, the Daniel G. Aldrich Research Award at the University of California Santa Barbara, and served as an invited scholar and instructor at the Santa Fe Institute for Complex Systems. In addition to his primary appointment in the Department of Medicine, Dr. Cole is also a member of the Norman Cousins Center, the Jonsson Comprehensive Cancer Center, and the UCLA Molecular Biology Institute.

Publications

Chang M, Brown H, Symensma T, Tanaka L, Arevalo J, Collado-Hidalgo A, Galic Z, Deng H, Zack J, Sun R, Cole S Beta-adrenergic stimulation of HHV-8 lytic gene expression via PKA-dependent control of viral RTA. Under review 2004; .

Zhou X, Rao NP, Cole SW, Mok SC, Chen Z, Wong DTW Current progress in concurrent analysis of loss of heterozygosity and comparative genomic hybridization utilizing high density oligonucleotide polymorphism arrays.. Cancer Genetics and Cytogenetics 2004; .

Zhou X, Cole SW, Cheng Z, Li Y, Wong DTW Identification of partial chromosomal deletion through binary recursive partitioning of microarray differential expression data. Journal of Medical Genetics 2004; In press.: .

Cole SW The complexity of dynamic host networks. The complexity of dynamic host networks 2003; .

Cole SW, Kemeny ME Psychosocial influences on the progression of HIV infection. Psychoneuroimmunology 2001; 2: 583-612.

Cole S, Knutson B, Wolkowitz O, Reus V Serotonergic neurotransmission modulates socially inhibited personality characteristics in normal humans.. Under review 2001; .

Cole SW, Jamieson BD, Zack JA cAMP externalizes lymphocyte CXCR4: Implications for chemotaxis and HIV infection.. Journal of Immunology 1999; 162: 1392-1400.

Cole SW, Korin YD, Fahey JL, Zack JA Norepineprhine accelerates HIV replication via progein kinase A-dependent effects on cytokine production.. Journal of Immunology 1998; 161: 610-616.

Cole SW, Knutson BD, Wolkowitz OL, Reus VI Serotonergic neurotransmission modulates socially inhibited personality characteristics in normal humans. 1998; .

Cole SW Blind T cell homeostasis and HIV infection.. Immunology Today 1997; 18: 505-506.

Cole SW, Kemeny ME Psychobiology of HIV infection.. Critical reviews in neurobiology. . 1997; 11(4): 289-321.

Cole SW, Kemeny ME, Taylor SE, Visscher BR, Fahey JL Accelerated course of human immunodeficiency virus infection in gay men who conceal their homosexual identity.. Psychosomatic medicine. . 1996; 58(3): 219-31.

Bower Julienne E, Ganz Patricia A, Tao May Lin, Hu Wenhua, Belin Thomas R, Sepah Saviz, Cole Steve, Aziz Najib Inflammatory biomarkers and fatigue during radiation therapy for breast and prostate cancer.. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009; 15(17): 5534-40.

Fuligni Andrew J, Telzer Eva H, Bower Julienne, Irwin Michael R, Kiang Lisa, Cole Steve W Daily family assistance and inflammation among adolescents from Latin American and European backgrounds.. Brain, behavior, and immunity. 2009; 23(6): 803-9.

Miller Gregory E, Chen Edith, Fok Alexandra K, Walker Hope, Lim Alvin, Nicholls Erin F, Cole Steve, Kobor Michael S Low early-life social class leaves a biological residue manifested by decreased glucocorticoid and increased proinflammatory signaling.. Proceedings of the National Academy of Sciences of the United States of America. 2009; 106(34): 14716-21.

Garcia-Ortiz José Elias, Pelosi Emanuele, Omari Shakib, Nedorezov Timur, Piao Yulan, Karmazin Jesse, Uda Manuela, Cao Antonio, Cole Steve W, Forabosco Antonino, Schlessinger David, Ottolenghi Chris Foxl2 functions in sex determination and histogenesis throughout mouse ovary development.. BMC developmental biology. 2009; 9(6): 36.

Cole Steve W, Mendoza Sally P, Capitanio John P Social stress desensitizes lymphocytes to regulation by endogenous glucocorticoids: insights from in vivo cell trafficking dynamics in rhesus macaques.. Psychosomatic medicine. 2009; 71(6): 591-7.

Fuligni Andrew J, Telzer Eva H, Bower Julienne, Cole Steve W, Kiang Lisa, Irwin Michael R A preliminary study of daily interpersonal stress and C-reactive protein levels among adolescents from Latin American and European backgrounds.. Psychosomatic medicine. 2009; 71(3): 329-33.

Lee Jeong-Won, Shahzad Mian M K, Lin Yvonne G, Armaiz-Pena Guillermo, Mangala Lingegowda S, Han Hee-Dong, Kim Hye-Sun, Nam Eun Ji, Jennings Nicholas B, Halder Jyotsnabaran, Nick Alpa M, Stone Rebecca L, Lu Chunhua, Lutgendorf Susan K, Cole Steve W, Lokshin Anna E, Sood Anil K Surgical stress promotes tumor growth in ovarian carcinoma.. Clinical cancer research : an official journal of the American Association for Cancer Research. 2009; 15(8): 2695-702.

Lutgendorf Susan K, DeGeest Koen, Sung Caroline Y, Arevalo Jesusa M, Penedo Frank, Lucci Joseph, Goodheart Michael, Lubaroff David, Farley Donna M, Sood Anil K, Cole Steve W Depression, social support, and beta-adrenergic transcription control in human ovarian cancer.. Brain, behavior, and immunity. 2009; 23(2): 176-83.

Miller Gregory, Chen Edith, Cole Steve W Health psychology: developing biologically plausible models linking the social world and physical health.. Annual review of psychology. 2009; 60(2): 501-24.

Miller Gregory E, Rohleder Nicolas, Cole Steve W Chronic interpersonal stress predicts activation of pro- and anti-inflammatory signaling pathways 6 months later.. Psychosomatic medicine. 2009; 71(1): 57-62.

Armaiz-Pena Guillermo N, Lutgendorf Susan K, Cole Steve W, Sood Anil K Neuroendocrine modulation of cancer progression.. Brain, behavior, and immunity. 2009; 23(1): 10-5.

Lutgendorf Susan K, Lamkin Donald M, Jennings Nicholas B, Arevalo Jesusa M G, Penedo Frank, DeGeest Koen, Langley Robert R, Lucci Joseph A, Cole Steve W, Lubaroff David M, Sood Anil K Biobehavioral influences on matrix metalloproteinase expression in ovarian carcinoma.. Clinical cancer research : an official journal of the American Association for Cancer Research. 2008; 14(21): 6839-46.

Cole Steve W Social regulation of leukocyte homeostasis: the role of glucocorticoid sensitivity.. Brain, behavior, and immunity. 2008; 22(7): 1049-55.

Irwin Michael R, Wang Minge, Ribeiro Denise, Cho Hyong Jin, Olmstead Richard, Breen Elizabeth Crabb, Martinez-Maza Otoniel, Cole Steve Sleep loss activates cellular inflammatory signaling.. Biological psychiatry. 2008; 64(6): 538-40.

Miller Gregory E, Chen Edith, Sze Jasmen, Marin Teresa, Arevalo Jesusa M G, Doll Richard, Ma Roy, Cole Steve W A functional genomic fingerprint of chronic stress in humans: blunted glucocorticoid and increased NF-kappaB signaling.. Biological psychiatry. 2008; 64(4): 266-72.

Kato Pamela M, Cole Steve W, Bradlyn Andrew S, Pollock Brad H A video game improves behavioral outcomes in adolescents and young adults with cancer: a randomized trial.. Pediatrics. 2008; 122(2): e305-17.

Collado-Hidalgo Brad H, Bower Brad H, Ganz Brad H, Irwin Brad H, Cole Brad H Cytokine gene polymorphisms and fatigue in breast cancer survivors: Early findings.. Brain, behavior, and immunity. 2008; 122(2): .

Capitanio John P, Abel Kristina, Mendoza Sally P, Blozis Shelley A, McChesney Michael B, Cole Steve W, Mason William A Personality and serotonin transporter genotype interact with social context to affect immunity and viral set-point in simian immunodeficiency virus disease.. Brain, behavior, and immunity. 2008; 22(5): 676-89.

Sloan Erica K, Capitanio John P, Tarara Ross P, Cole Steve W Social temperament and lymph node innervation.. Brain, behavior, and immunity. 2008; 22(5): 717-26.

Cole Steve W Psychosocial influences on HIV-1 disease progression: neural, endocrine, and virologic mechanisms.. Psychosomatic medicine. 2008; 70(5): 562-8.

Fouse Shaun D, Shen Yin, Pellegrini Matteo, Cole Steve, Meissner Alexander, Van Neste Leander, Jaenisch Rudolf, Fan Guoping Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation.. Cell stem cell. 2008; 2(2): 160-9.

Sloan Erica K, Nguyen Christina T, Cox Benjamin F, Tarara Ross P, Capitanio John P, Cole Steve W SIV infection decreases sympathetic innervation of primate lymph nodes: the role of neurotrophins.. Brain, behavior, and immunity. 2008; 22(2): 185-94.

Sloan Erica K, Capitanio John P, Cole Steve W Stress-induced remodeling of lymphoid innervation.. Brain, behavior, and immunity. 2008; 22(1): 15-21.

Landen Charles N, Lin Yvonne G, Armaiz Pena Guillermo N, Das Pamela D, Arevalo Jesusa M, Kamat Aparna A, Han Liz Y, Jennings Nicholas B, Spannuth Whitney A, Thaker Premal H, Lutgendorf Susan K, Savary Cherylyn A, Sanguino Angela M, Lopez-Berestein Gabriel, Cole Steve W, Sood Anil K Neuroendocrine modulation of signal transducer and activator of transcription-3 in ovarian cancer.. Cancer research. 2007; 67(21): 10389-96.

Beale Ivan L, Kato Pamela M, Marin-Bowling Veronica M, Guthrie Nicole, Cole Steve W Improvement in cancer-related knowledge following use of a psychoeducational video game for adolescents and young adults with cancer.. The Journal of adolescent health : official publication of the Society for Adolescent Medicine. 2007; 41(3): 263-70.

Sloan Erica K, Capitanio John P, Tarara Ross P, Mendoza Sally P, Mason William A, Cole Steve W Social stress enhances sympathetic innervation of primate lymph nodes: mechanisms and implications for viral pathogenesis.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007; 27(33): 8857-65.

Bower Julienne E, Ganz Patricia A, Aziz Najib, Olmstead Richard, Irwin Michael R, Cole Steve W Inflammatory responses to psychological stress in fatigued breast cancer survivors: relationship to glucocorticoids.. Brain, behavior, and immunity. 2007; 21(3): 251-8.

Irwin Michael R, Olmos Luis, Wang Minge, Valladares Edwin M, Motivala Sarosh J, Fong Tim, Newton Tom, Butch Anthony, Olmstead Richard, Cole Steve W Cocaine dependence and acute cocaine induce decreases of monocyte proinflammatory cytokine expression across the diurnal period: autonomic mechanisms.. The Journal of pharmacology and experimental therapeutics. 2007; 320(2): 507-15.

Cole Steve W, Hawkley Louise C, Arevalo Jesusa M, Sung Caroline Y, Rose Robert M, Cacioppo John T Social regulation of gene expression in human leukocytes.. Genome biology. 2007; 8(9): R189.

Collado-Hidalgo Alicia, Sung Caroline, Cole Steve Adrenergic inhibition of innate anti-viral response: PKA blockade of Type I interferon gene transcription mediates catecholamine support for HIV-1 replication.. Brain, behavior, and immunity. 2006; 20(6): 552-63.

Irwin Michael R, Wang Minge, Campomayor Capella O, Collado-Hidalgo Alicia, Cole Steve Sleep deprivation and activation of morning levels of cellular and genomic markers of inflammation.. Archives of internal medicine. 2006; 166(16): 1756-62.

Sloan Erica K, Tarara Ross P, Capitanio John P, Cole Steve W Enhanced replication of simian immunodeficiency virus adjacent to catecholaminergic varicosities in primate lymph nodes.. Journal of virology. 2006; 80(9): 4326-35.

Collado-Hidalgo Alicia, Bower Julienne E, Ganz Patricia A, Cole Steve W, Irwin Michael R Inflammatory biomarkers for persistent fatigue in breast cancer survivors.. Clinical cancer research : an official journal of the American Association for Cancer Research. 2006; 12(9): 2759-66.

Chang Margaret, Brown Helen J, Collado-Hidalgo Alicia, Arevalo Jesusa M, Galic Zoran, Symensma Tonia L, Tanaka Lena, Deng Hongyu, Zack Jerome A, Sun Ren, Cole Steve W beta-Adrenoreceptors reactivate Kaposi's sarcoma-associated herpesvirus lytic replication via PKA-dependent control of viral RTA.. Journal of virology. 2005; 79(21): 13538-47.

Sinaceur Marwan, Heath Chip, Cole Steve Emotional and deliberative reactions to a public crisis: Mad Cow disease in France.. Psychological science : a journal of the American Psychological Society / APS. 2005; 16(3): 247-54.

Cole Steve W, Yan Weihong, Galic Zoran, Arevalo Jesusa, Zack Jerome A Expression-based monitoring of transcription factor activity: the TELiS database.. Bioinformatics (Oxford, England). 2005; 21(6): 803-10.

Cole SW, Yan W, Galic Z, Arevalo J, Zack JA Expression-based monitoring of transcription factor activity: the TELiS database.. Bioinformatics (Oxford, England) . 2005; 21(6): 803-10.

Bradlyn Andrew S, Kato Pamela M, Beale Ivan L, Cole Steve Pediatric oncology professionals' perceptions of information needs of adolescent patients with cancer.. Journal of pediatric oncology nursing : official journal of the Association of Pediatric Oncology Nurses. 2005; 21(6): 335-42.

Chen Edith, Cole Steve W, Kato Pamela M A review of empirically supported psychosocial interventions for pain and adherence outcomes in sickle cell disease.. Journal of pediatric psychology. 2004; 29(3): 197-209.

Chen Hongying, Zha Junli, Gowans Reginald E, Camargo Paulo, Nishitani Junko, McQuirter Joseph L, Cole Steve W, Zack Jerome A, Liu Xuan Alcohol enhances HIV type 1 infection in normal human oral keratinocytes by up-regulating cell-surface CXCR4 coreceptor.. AIDS research and human retroviruses. 2004; 20(5): 513-9.

Chen H, Zha J, Gowans RE, Camargo P, Nishitani J, McQuirter JL, Cole SW, Zack JA, Liu X Alcohol enhances HIV type 1 infection in normal human oral keratinocytes by up-regulating cell-surface CXCR4 coreceptor.. AIDS research and human retroviruses. . 2004; 20(5): 513-9.

Richlin Vanessa A, Arevalo Jesusa M G, Zack Jerome A, Cole Steve W Stress-induced enhancement of NF-kappaB DNA-binding in the peripheral blood leukocyte pool: effects of lymphocyte redistribution.. Brain, behavior, and immunity. 2004; 18(3): 231-7.

Richlin VA, Arevalo JM, Zack JA, Cole SW Stress-induced enhancement of NF-kappaB DNA-binding in the peripheral blood leukocyte pool: effects of lymphocyte redistribution.. Brain, behavior, and immunity. . 2004; 18(3): 231-7.

Zhou X, Cole SW, Hu S, Wong DT Detection of DNA copy number abnormality by microarray expression analysis.. Human genetics. . 2004; 114(5): 464-7.

Amado Rafael G, Mitsuyasu Ronald T, Rosenblatt Joseph D, Ngok Frances K, Bakker Andreas, Cole Steve, Chorn Nathalie, Lin Lii-Shin, Bristol Gregory, Boyd Maureen P, MacPherson Janet L, Fanning Gregory C, Todd Alison V, Ely Julie A, Zack Jerome A, Symonds Geoff P Anti-human immunodeficiency virus hematopoietic progenitor cell-delivered ribozyme in a phase I study: myeloid and lymphoid reconstitution in human immunodeficiency virus type-1-infected patients.. Human gene therapy. 2004; 15(3): 251-62.

Cole SW, Kemeny ME, Fahey JL, Zack JA, Naliboff BD Psychological risk factors for HIV pathogenesis: mediation by the autonomic nervous system.. Biological psychiatry. . 2003; 54(12): 1444-56.

Symensma Tonia L, Martinez-Guzman DeeAnn, Jia Qingmei, Bortz Eric, Wu Ting-Ting, Rudra-Ganguly Nandini, Cole Steve, Herschman Harvey, Sun Ren COX-2 induction during murine gammaherpesvirus 68 infection leads to enhancement of viral gene expression.. Journal of virology. 2003; 77(23): 12753-63.

Symensma TL, Martinez-Guzman D, Jia Q, Bortz E, Wu TT, Rudra-Ganguly N, Cole S, Herschman H, Sun R COX-2 induction during murine gammaherpesvirus 68 infection leads to enhancement of viral gene expression.. Journal of virology. . 2003; 77(23): 12753-63.

Cole Steve W, Kemeny Margaret E, Fahey John L, Zack Jerome A, Naliboff Bruce D Psychological risk factors for HIV pathogenesis: mediation by the autonomic nervous system.. Biological psychiatry. 2003; 54(12): 1444-56.

Cole SW, Galic Z, Zack JA Controlling false-negative errors in microarray differential expression analysis: a PRIM approach.. Bioinformatics (Oxford, England) . 2003; 19(14): 1808-16.

Cole Steve W, Galic Zoran, Zack Jerome A Controlling false-negative errors in microarray differential expression analysis: a PRIM approach.. Bioinformatics (Oxford, England). 2003; 19(14): 1808-16.

Bower JE, Ganz PA, Aziz N, Fahey JL, Cole SW T-cell homeostasis in breast cancer survivors with persistent fatigue.. Journal of the National Cancer Institute. . 2003; 95(15): 1165-8.

Bower Julienne E, Ganz Patricia A, Aziz Najib, Fahey John L, Cole Steve W T-cell homeostasis in breast cancer survivors with persistent fatigue.. Journal of the National Cancer Institute. 2003; 95(15): 1165-8.

Liu Xuan, Zha Junli, Chen Hongying, Nishitani Junko, Camargo Paulo, Cole Steve W, Zack Jerome A Human immunodeficiency virus type 1 infection and replication in normal human oral keratinocytes.. Journal of virology. 2003; 77(6): 3470-6.

Liu X, Zha J, Chen H, Nishitani J, Camargo P, Cole SW, Zack JA Human immunodeficiency virus type 1 infection and replication in normal human oral keratinocytes.. Journal of virology. . 2003; 77(6): 3470-6.

Arjomand Jamshid, Cole Steve, Evans Chris J Novel orphanin FQ/nociceptin transcripts are expressed in human immune cells.. Journal of neuroimmunology. 2002; 130(1-2): 100-8.

Cohan Catherine L, Cole Steve W Life course transitions and natural disaster: marriage, birth, and divorce following Hurricane Hugo.. Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43). 2002; 16(1): 14-25.

Cole SW, Naliboff BD, Kemeny ME, Griswold MP, Fahey JL, Zack JA Impaired response to HAART in HIV-infected individuals with high autonomic nervous system activity.. Proceedings of the National Academy of Sciences of the United States of America. . 2001; 98(22): 12695-700.

Cole SW, Kemeny ME, Weitzman OB, Schoen M, Anton PA Socially inhibited individuals show heightened DTH response during intense social engagement.. Brain, behavior, and immunity. . 1999; 13(2): 187-200.

Cole SW, Kemeny ME, Taylor SE Social identity and physical health: accelerated HIV progression in rejection-sensitive gay men.. Journal of personality and social psychology. . 1997; 72(2): 320-35.

Knutson B, Cole S, Wolkowitz O, Reus V, Chan T, Moore E Serotonergic intervention increases affiliative behavior in humans.. Annals of the New York Academy of Sciences. . 1997; 807: 492-3.

Cole SW, Kemeny ME, Taylor SE, Visscher BR Elevated physical health risk among gay men who conceal their homosexual identity.. Health psychology : official journal of the Division of Health Psychology, American Psychological Association. . 1996; 15(4): 243-51.

Centers, Programs, Divisions and other groups

Cousins Center for Psychoneuroimmunology Faculty