Joseph Watson
Email
jwatson@mednet.ucla.edu
Phone
Work Phone Number:
310-206-7745
310-825-7587
Address
Work Address:
Office760 Westwood Plaza Los Angeles, CA 90095UNITED STATES
Laboratory760 Westwood PlazaLos Angeles, CA 90095UNITED STATES
Dr. Watson received his Ph.D from the Department of Chemistry and Biochemistry at UCLA in 1985 in Jay Gralla's Laboratory in which he combined virology and protein biochemistry to identify early SV40 virus replication and transcription complexes associated with the nuclear matrix of eukaryotic cells. He then went on to do a postdoctoral fellowship in molecular biology of the nervous system in Dr. J. Gregor Sutcliffe?s lab at The Scripps Research Institute in La Jolla, CA, where he began his initial studies of neurodegenerative diseases focusing on identifying novel genes relevant to Huntington?s Disease. He returned to UCLA in 1989 as a member of the Mental Retardation Research Center and the Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine at UCLA, studying synaptic targets of neurodegenerative diseases that include both Parkinson?s Disease (PD) and Alzheimer?s Disease (AD). He is also the Vice Chair of the Neuroscience Undergraduate Interdepartmental Program for the UCLA campus and Outreach Program Director for the Brain Research Institute (BRI).
Publications
Watson, J.B. Subtractive cDNA Hybridization and Brain: Then, Now, and Tomorrow..
Handbook of Molecular-Genetic Techniques for Brain and Behavior Research (Techniques in the Behavior
1999; Vol. 13:
189-199.
Romero-Calderón Rafael, O'Hare Elizabeth D, Suthana Nanthia A, Scott-Van Zeeland Ashley A, Rizk-Jackson Angela, Attar Aida, Madsen Sarah K, Ghiani Cristina A, Evans Christopher J, Watson Joseph B Project brainstorm: using neuroscience to connect college students
with local schools..
PLoS biology.
2012; 10(4):
e1001310.
Cummings Damian M, Alaghband Yasaman, Hickey Miriam A, Joshi Prasad R, Hong S Candice, Zhu Chunni, Ando Timothy K, André Véronique M, Cepeda Carlos, Watson Joseph B, Levine Michael S A critical window of CAG repeat-length correlates with phenotype
severity in the R6/2 mouse model of Huntington's disease..
Journal of neurophysiology.
2012; 107(2):
677-91.
Zeng Yan, Tan Miao, Kohyama Jun, Sneddon Marissa, Watson Joseph B, Sun Yi E, Xie Cui-Wei Epigenetic enhancement of BDNF signaling rescues synaptic plasticity
in aging..
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2011; 31(49):
17800-10.
Cepeda Carlos, Cummings Damian M, Hickey Miriam A, Kleiman-Weiner Max, Chen Jane Y, Watson Joseph B, Levine Michael S Rescuing the Corticostriatal Synaptic Disconnection in the R6/2 Mouse
Model of Huntington's Disease: Exercise, Adenosine Receptors and
Ampakines..
PLoS currents.
2010; 2(2):
.
Watson J B, Hatami A, David H, Masliah E, Roberts K, Evans C E, Levine M S Alterations in corticostriatal synaptic plasticity in mice overexpressing human alpha-synuclein..
Neuroscience.
2009; 159(2):
501-13.
Fox Rebecca M, Watson Joseph D, Von Stetina Stephen E, McDermott Joan, Brodigan Thomas M, Fukushige Tetsunari, Krause Michael, Miller David M The embryonic muscle transcriptome of Caenorhabditis elegans..
Genome biology.
2007; 8(9):
R188.
Watson J B, Arnold M M, Ho Y-S, O'Dell T J Age-dependent modulation of hippocampal long-term potentiation by
antioxidant enzymes..
Journal of neuroscience research.
2006; 84(7):
1564-74.
Zhao Danyun, Watson Joseph B, Xie Cui-Wei Amyloid beta prevents activation of calcium/calmodulin-dependent
protein kinase II and AMPA receptor phosphorylation during hippocampal
long-term potentiation..
Journal of neurophysiology.
2004; 92(5):
2853-8.
Chotiner J K, Khorasani H, Nairn A C, O'Dell T J, Watson J B Adenylyl cyclase-dependent form of chemical long-term potentiation
triggers translational regulation at the elongation step..
Neuroscience.
2003; 116(3):
743-52.
Watson J B, Khorasani H, Persson A, Huang K-P, Huang F L, O'Dell T J Age-related deficits in long-term potentiation are insensitive to
hydrogen peroxide: coincidence with enhanced autophosphorylation of
Ca2+/calmodulin-dependent protein kinase II..
Journal of neuroscience research.
2002; 70(3):
298-308.
Cepeda Carlos, Crawford Cynthia A, Margulies Jody E, Watson Joseph B, Levine Michael S, Cohen Randy W Enhanced epileptogenic susceptibility in a genetic model of reactive
synaptogenesis: the spastic Han-Wistar rat..
Developmental neuroscience.
2002; 24(4):
262-71.
Makhinson M, Chotiner J K, Watson J B, O'Dell T J Adenylyl cyclase activation modulates activity-dependent changes in
synaptic strength and Ca2+/calmodulin-dependent kinase II
autophosphorylation..
The Journal of neuroscience : the official journal of the Society for Neuroscience.
1999; 19(7):
2500-10.
Johnson M W, Chotiner J K, Watson J B Isolation and characterization of synaptoneurosomes from single rat
hippocampal slices..
Journal of neuroscience methods.
1997; 77(2):
151-6.
Chang, JW Schumacher, E Coulter, PM Vinters, HV Watson, JB Dendritic translocation of RC3/neurogranin mRNA in normal aging, Alzheimer disease and fronto-temporal dementia..
Journal of neuropathology and experimental neurology. .
1997; 56(10):
1105-18.
