Jerome Siegel

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Publications

See: http://www.npi.ucla.edu/sleepresearch . ; .
Siegel, J.M. A tribute to Nathaniel Kleitman.. Arch. Ital. Biol. 2001; 139: 3-10.
Eiland, M.M., Lyamin, O.I. and Siegel, J.M. State related discharge of neruons in the brainstem of freely moving box turtles, Terapene Carolina major.. Arch. Ital. Biol. 2001; 139: 23-36.
Siegel, J. M. Brainstem mechanisms generating REM sleep.. Principles and Practice of Sleep Medicine 2000; Third Edition: 112-133.
Siegel, J. M. Brainstem mechanisms generating REM sleep.. Principles and Practice of Sleep Medicine 2000; Third Edition: 112-133.
Siegel, J.M. Narcolepsy.. Scientific American 2000; 282: 76-81.
Siegel, J.M. Phylogenetic data bearing on the REM sleep-learning connection.. The Behavioral and Brain Sciences 2000; 23: 1007.
Lyamin, O.I., Manger,P.R. Mukhametov, L.M., Siegel, J.M.and Shpak, O.V. Rest and activity states in a gray whale.. J. Sleep Res. 2000; 9: 261-267.
Rechtschaffen, A. and Siegel, J.M. Sleep and Dreaming.. Principles of Neuroscience. 2000; Fourth Edition: 936-947.
John, J Wu, MF Siegel, JM Systemic administration of hypocretin-1 reduces cataplexy and normalizes sleep and waking durations in narcoleptic dogs.. Sleep research online [electronic resource] : SRO. . 2000; 3(1): 23-8.
Wu, MF Gulyani, SA Yau, E Mignot, E Phan, B Siegel, JM Locus coeruleus neurons: cessation of activity during cataplexy.. Neuroscience. . 1999; 91(4): 1389-99.
Siegel, J.M. Narcolepsy: A key role for hypocretins (orexins).. Cell 1999; 98: 409-412.
Lai. Y.Y., Shalita, T., Hajnik, T., Wu, J.-P., Kuo, J.-S., Chia, L.-G., and Siegel, J.M. Neurotoxic Nmethyl-D-Aspartate lesion of the ventral midbrain and mesopontine junction alters sleep-wake organization.. Neuroscience 1999; 90: 469-483.
Siegel, JM Manger, PR Nienhuis, R Fahringer, HM Shalita, T Pettigrew, JD Sleep in the platypus.. Neuroscience. . 1999; 91(1): 391-400.
Siegel, J.M. Sleep.. Encarta Encyclopedia 1999; 2000: 0000.
Siegel, J.M. Sleep.. Encarta Encyclopedia 1999; 2000: 0000.
Siegel, J.M. The evolution of REM sleep.. In Handbook of Behavioral State Control 1999; first edition: pp 87-100.
Kohyama, J., Lai, Y.Y. and Siegel, J.M. Conduction velocity of the reticulospinal system mediating muscle tone suppression.. J. Neurophysiol. 1998; 80: 1839-1851.
Lai, Y.Y. and Siegel, J.M. Muscle atonia and REM sleep.. Rapid eye movement sleep 1998; first edition: 69-90.
Nitz, D. and Siegel, J.M. GABA release in the locus coeruleus as a function of sleep/wake state.. Neuroscience 1997; 78: 795-801.
Siegel, J.M. Sleep in monotremes; implications for the evolution of REM sleep.. Sleep and sleep disorders: from molecule to behavior 1997; First edition: 113-128.
Siegel, J.M. and Harper, R.H. Sleep.. Human Physiology 1996; 1: 1183-1197.
Siegel, J.M. and Harper, R.H. Sleep.. Human Physiology 1996; 1: 1183-1197.
Nishino, S., Tafti, M., Reid, M., Shelton, J., Siegel, J.M., Dement, W.C., and Mignot, E. Muscle atonia is triggered by cholinergic stimulation of the basal forebrain: Implications for the pathophysiology of narcolepsy.. J. Neuroscience 1995; 15: 4806-4814.
Siegel, JM Phylogeny and the function of REM sleep.. Behavioural brain research. . 1995; 69(1-2): 29-34.
Siegel, J. M. Brainstem mechanisms generating REM sleep.. Principles and Practice of Sleep Medicine 1994; Third Edition: 125-144.
Siegel, J.M., and Lai, Y.Y. Brainstem systems mediating the control of muscle tone.. Environment and Physiology 1994; First Edition: 62-78.
Carskadon, M.A., Rechtschaffen, A., Richardson, G., Roth, T., Siegel, J.M.v (Editor).. Encyclopedia of Sleep and Dreaming 1993; 703 pages.
Kodama, T., and Siegel, J.M. Brainstem acetylcholine release and REM sleep.. Sleep Wakefulness 1993; First edition: 51-56.
Wu, M.F, Jenden, D.J., Fairchild, D.M. and Siegel, J.M. Cholinergic mechanisms in startle and prepulse inhibition:Effect of the false cholinergic precursor N-aminodeanol.. Behavioral Neurosci. 1993; 107: 306-316.
Siegel, J.M. Function of REM sleep.. Encyclopedia of Sleep and Dreaming 1993; First Edition: 507-510.
Siegel, J.M. Medulla.. Encyclopedia of Sleep and Dreaming 1993; 358-359.
Siegel, J.M. Pons.. Encyclopedia of Sleep and Dreaming 1993; First edition: 461-462.
Siegel, J.M. REM sleep Mechanisms.. Encyclopedia of Sleep and Dreaming 1993; First Edition: 510-513.
Kodama, T., Lai, Y.Y. and Siegel, J.M. Enhancement of acetylcholine release during REM sleep in the caudo-medial medulla measured by in vivo microdialysis.. Brain Res. 1992; 580: 348-350.
McGinty, D. J. and Siegel, J. M. Neuronal unit recording in unrestrained animals: Role in structure-function analysis of sleep-waking mechanisms.. Progress in Physiological Psychology 1992; 15: 85-140.
Siegel, J.M. Brain Mechanisms of Sleep and Wakefulness.. Basics of Sleep Behavior 1991; .
Lai, Y.Y. and Siegel, J.M. Ponto-medullary glutamate receptors mediating locomotion and muscle tone suppression.. J. Neurosci. 1991; 11: 2931-2937.
Shouse, M. N., King, A., Langer, J., Wellesley, K., Vreeken, T., King, K., Siegel, J., Szymusiak, R. Basic mechanisms underlying seizure prone and seizure resistant sleep states.. Kindling 1990; 4: 313-327.
Siegel, J. M. Mechanisms of sleep control.. J. Clin Neurophysiol. 1990; 7: 49-65.
Siegel, J. M. Brainstem mechanisms generating REM sleep.. Principles and Practice of Sleep Medicine 1989; 104-121.
Siegel, J. M. Brainstem mechanisms generating REM sleep.. Principles and Practice of Sleep Medicine 1989; 104-121.
Wu, M.F., Mallick, B.N. and Siegel J.M. Lateral geniculate spikes, muscle atonia and startle response elicited by auditory stimuli as a function of stimulus parameters and arousal state.. Brain Res. 1989; 499: 7-17.
Lai, Y. Y., Siegel, J. M. and Wilson, W. J. Effect of blood pressure manipulations on medial medulla-induced muscle atonia.. Am. J. Physiol. 1987; 252: H1249-H1257.
Siegel, J. M., Tomaszewski, K. S. and Nienhuis, R. Behavioral states in the chronic medullary and mid-pontine cat.. Electroenceph. clin Neurophysiol. 1986; 63: 274-288.
Siegel, JM Fahringer, H Tomaszewski, KS Kaitin, K Kilduff, T Dement, WC Heart rate and blood pressure changes associated with cataplexy in canine narcolepsy.. Sleep. . 1986; 9(1 Pt 2): 216-21.
Siegel, J. M. and McGinty, D. J. Location of the systems generating REM sleep: lateral vs. medial pons. Commentary.. Behav. Brain Sci. 1986; 9: 420-421.
Siegel, J. M. Pontomedullary interactions in the generation of REM sleep.. Brain Mechanisms of Sleep 1985; 157-174.
Siegel, J. M. A behavioral approach to the analysis of reticular formation unit activity.. Behavioral Approaches to Brain Research 1983; 94-116.
Siegel, J. M. Brainstem mechanisms in REM sleep control.. Sleep Functions and Mechanisms in Animals and Man: An Evolutionary Perspective. 1983; 217-231.
Siegel, J. M. Reticular activity and arousal. Commentary.. Behav. Brain Sci. 1983; 6: 741-743.
McGinty, D. J. and Siegel, J. M. Sleep states.. Handbook of Behavioral Neurobiology: Motivation 1983; 105-181.
Siegel, J. M. Behavioral functions of the reticular formation.. Brain Res. Rev. 1979; 1: 69-105.
Breedlove, SM McGinty, DJ Siegel, JM Operant conditioning of pontine gigantocellular units.. Brain research bulletin. . 1979; 4(5): 663-7.
Siegel, J. M. Reticular formation activity and REM sleep.. The Functions of Sleep 1979; 37-71.
Siegel, J. M. and McGinty, D. J. Pontine reticular formation neurons and motor activity.. Science 1978; 199: 207-208.
McGinty, D. J. and Siegel, J. M. Neuronal activity patterns during rapid-eye- movement sleep:relation to waking patterns.. Neurobiology of Sleep and Memory 1977; 135-158.
Siegel, J. M. and McGinty, D. J. Brainstem neurons without spontaneous unit discharge.. Science 1976; 193: 240-242.
Kiyashchenko, LI Mileykovskiy, BY Lai, YY Siegel, JM Increased and decreased muscle tone with orexin (hypocretin) microinjections in the locus coeruleus and pontine inhibitory area.. Journal of neurophysiology. . 2001; 85(5): 2008-16.
Mileykovskiy, BY Kiyashchenko, LI Kodama, T Lai, YY Siegel, JM Activation of pontine and medullary motor inhibitory regions reduces discharge in neurons located in the locus coeruleus and the anatomical equivalent of the midbrain locomotor region.. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 2000; 20(22): 8551-8.
Hajnik, T Lai, YY Siegel, JM Atonia-related regions in the rodent pons and medulla.. Journal of neurophysiology. . 2000; 84(4): 1942-8.
Thannickal, TC Moore, RY Nienhuis, R Ramanathan, L Gulyani, S Aldrich, M Cornford, M Siegel, JM Reduced number of hypocretin neurons in human narcolepsy.. Neuron. . 2000; 27(3): 469-74.
Lai, YY Clements, JR Wu, XY Shalita, T Wu, JP Kuo, JS Siegel, JM Brainstem projections to the ventromedial medulla in cat: retrograde transport horseradish peroxidase and immunohistochemical studies.. The Journal of comparative neurology. . 1999; 408(3): 419-36.
Siegel, JM Nienhuis, R Gulyani, S Ouyang, S Wu, MF Mignot, E Switzer, RC McMurry, G Cornford, M Neuronal degeneration in canine narcolepsy.. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 1999; 19(1): 248-57.
Kohyama, J Lai, YY Siegel, JM Inactivation of the pons blocks medullary-induced muscle tone suppression in the decerebrate cat.. Sleep. . 1998; 21(7): 695-9.
Siegel, JM Manger, PR Nienhuis, R Fahringer, HM Pettigrew, JD Monotremes and the evolution of rapid eye movement sleep.. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. . 1998; 353(1372): 1147-57.
Reid, MS Nishino, S Tafti, M Siegel, JM Dement, WC Mignot, E Neuropharmacological characterization of basal forebrain cholinergic stimulated cataplexy in narcoleptic canines.. Experimental neurology. . 1998; 151(1): 89-104.
Kodama, T Lai, YY Siegel, JM Enhanced glutamate release during REM sleep in the rostromedial medulla as measured by in vivo microdialysis.. Brain research. . 1998; 780(1): 178-81.
Nitz, D Siegel, J GABA release in the dorsal raphe nucleus: role in the control of REM sleep.. The American journal of physiology. . 1997; 273(1 Pt 2): R451-5.
Lai, YY Siegel, JM Brainstem-mediated locomotion and myoclonic jerks. I. Neural substrates.. Brain research. . 1997; 745(1-2): 257-64.
Lai, YY Siegel, JM Brainstem-mediated locomotion and myoclonic jerks. II Pharmacological effects.. Brain research. . 1997; 745(1-2): 265-70.
Nitz, D Siegel, JM GABA release in posterior hypothalamus across sleep-wake cycle.. The American journal of physiology. . 1996; 271(6 Pt 2): R1707-12.
Reid, MS Tafti, M Nishino, S Sampathkumaran, R Siegel, JM Mignot, E Local administration of dopaminergic drugs into the ventral tegmental area modulates cataplexy in the narcoleptic canine.. Brain research. . 1996; 733(1): 83-100.
Siegel, JM Manger, PR Nienhuis, R Fahringer, HM Pettigrew, JD The echidna Tachyglossus aculeatus combines REM and non-REM aspects in a single sleep state: implications for the evolution of sleep.. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 1996; 16(10): 3500-6.
Nitz, D Andersen, A Fahringer, H Nienhuis, R Mignot, E Siegel, J Altered distribution of cholinergic cells in the narcoleptic dog.. Neuroreport. . 1995; 6(11): 1521-4.
Reid, MS Tafti, M Nishino, S Siegel, JM Dement, WC Mignot, E Cholinergic regulation of cataplexy in canine narcolepsy in the pontine reticular formation is mediated by M2 muscarinic receptors.. Sleep. . 1994; 17(5): 424-35.
Reid, MS Tafti, M Geary, JN Nishino, S Siegel, JM Dement, WC Mignot, E Cholinergic mechanisms in canine narcolepsy--I. Modulation of cataplexy via local drug administration into the pontine reticular formation.. Neuroscience. . 1994; 59(3): 511-22.
Reid, MS Siegel, JM Dement, WC Mignot, E Cholinergic mechanisms in canine narcolepsy--II. Acetylcholine release in the pontine reticular formation is enhanced during cataplexy.. Neuroscience. . 1994; 59(3): 523-30.
Lai, YY Clements, JR Siegel, JM Glutamatergic and cholinergic projections to the pontine inhibitory area identified with horseradish peroxidase retrograde transport and immunohistochemistry.. The Journal of comparative neurology. . 1993; 336(3): 321-30.
Mignot, E Nishino, S Sharp, LH Arrigoni, J Siegel, JM Reid, MS Edgar, DM Ciaranello, RD Dement, WC Heterozygosity at the canarc-1 locus can confer susceptibility for narcolepsy: induction of cataplexy in heterozygous asymptomatic dogs after administration of a combination of drugs acting on monoaminergic and cholinergic systems.. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 1993; 13(3): 1057-64.
Baghdoyan, HA Spotts, JL Snyder, SG Simultaneous pontine and basal forebrain microinjections of carbachol suppress REM sleep.. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 1993; 13(1): 229-42.
Siegel, JM Nienhuis, R Fahringer, HM Chiu, C Dement, WC Mignot, E Lufkin, R Activity of medial mesopontine units during cataplexy and sleep-waking states in the narcoleptic dog.. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 1992; 12(5): 1640-6.
Lai, YY Siegel, JM Corticotropin-releasing factor mediated muscle atonia in pons and medulla.. Brain research. . 1992; 575(1): 63-8.
Shouse, MN Siegel, JM Pontine regulation of REM sleep components in cats: integrity of the pedunculopontine tegmentum (PPT) is important for phasic events but unnecessary for atonia during REM sleep.. Brain research. . 1992; 571(1): 50-63.
Mallick, BN Fahringer, HM Wu, MF Siegel, JM REM sleep deprivation reduces auditory evoked inhibition of dorsolateral pontine neurons.. Brain research. . 1991; 552(2): 333-7.
Siegel, JM Nienhuis, R Fahringer, HM Paul, R Shiromani, P Dement, WC Mignot, E Chiu, C Neuronal activity in narcolepsy: identification of cataplexy-related cells in the medial medulla.. Science. . 1991; 252(5010): 1315-8.
Wu, MF Siegel, JM Facilitation of the acoustic startle reflex by ponto-geniculo-occipital waves: effects of PCPA.. Brain research. . 1990; 532(1-2): 237-41.
Wu, MF Siegel, JM Shouse, MN Schenkel, E Lesions producing REM sleep without atonia disinhibit the acoustic startle reflex without affecting prepulse inhibition.. Brain research. . 1990; 528(2): 330-4.
Lai, YY Siegel, JM Muscle tone suppression and stepping produced by stimulation of midbrain and rostral pontine reticular formation.. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 1990; 10(8): 2727-34.
Shiromani, PJ Lai, YY Siegel, JM Descending projections from the dorsolateral pontine tegmentum to the paramedian reticular nucleus of the caudal medulla in the cat.. Brain research. . 1990; 517(1-2): 224-8.
Mallick, BN Siegel, JM Fahringer, H Changes in pontine unit activity with REM sleep deprivation.. Brain research. . 1990; 515(1-2): 94-8.
Lai, YY Siegel, JM Cardiovascular and muscle tone changes produced by microinjection of cholinergic and glutamatergic agonists in dorsolateral pons and medial medulla.. Brain research. . 1990; 514(1): 27-36.
Shouse, MN Siegel, JM Wu, MF Szymusiak, R Morrison, AR Mechanisms of seizure suppression during rapid-eye-movement (REM) sleep in cats.. Brain research. . 1989; 505(2): 271-82.
Suzuki, SS Siegel, JM Wu, MF Role of pontomedullary reticular formation neurons in horizontal head movements: an ibotenic acid lesion study in the cat.. Brain research. . 1989; 484(1-2): 78-93.
Schenkel, E Siegel, JM REM sleep without atonia after lesions of the medial medulla.. Neuroscience letters. . 1989; 98(2): 159-65.
Schenkel, E Siegel, JM REM sleep without atonia after lesions of the medial medulla.. Neuroscience letters. . 1989; 98(2): 159-65.
Schenkel, E Siegel, JM REM sleep without atonia after lesions of the medial medulla.. Neuroscience letters. . 1989; 98(2): 159-65.
Schenkel, E Siegel, JM REM sleep without atonia after lesions of the medial medulla.. Neuroscience letters. . 1989; 98(2): 159-65.
Nienhuis, R Siegel, JM Analysis of head movement and position using hall effect devices.. Physiology & behavior. . 1989; 45(1): 199-203.
Siegel, JM Tomaszewski, KS Fahringer, H Cave, G Kilduff, T Dement, WC Heart rate and blood pressure changes during sleep-waking cycles and cataplexy in narcoleptic dogs.. The American journal of physiology. . 1989; 256(1 Pt 2): H111-9.
Lai, YY Siegel, JM Medullary regions mediating atonia.. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 1988; 8(12): 4790-6.
Siegel, JM Rogawski, MA A function for REM sleep: regulation of noradrenergic receptor sensitivity.. Brain research. . 1988; 472(3): 213-33.
Wu, MF Suzuki, SS Siegel, JM Anatomical distribution and response patterns of reticular neurons active in relation to acoustic startle.. Brain research. . 1988; 457(2): 399-406.
Shiromani, PJ Siegel, JM Tomaszewski, KS McGinty, DJ Alterations in blood pressure and REM sleep after pontine carbachol microinfusion.. Experimental neurology. . 1986; 91(2): 285-92.
Suzuki, SS Siegel, JM Reticular formation neurons related to tongue movement in the behaving cat.. Experimental neurology. . 1985; 89(3): 689-97.
Siegel, JM Nienhuis, R Tomaszewski, KS REM sleep signs rostral to chronic transections at the pontomedullary junction.. Neuroscience letters. . 1984; 45(3): 241-6.
Siegel, JM Tomaszewski, KS Behavioral organization of reticular formation: studies in the unrestrained cat. I. Cells related to axial, limb, eye, and other movements.. Journal of neurophysiology. . 1983; 50(3): 696-716.
Siegel, JM Tomaszewski, KS Wheeler, RL Behavioral organization of reticular formation: studies in the unrestrained cat. II. Cells related to facial movements.. Journal of neurophysiology. . 1983; 50(3): 717-23.
Siegel, JM Nienhuis, R Tomaszewski, KS Rostral brainstem contributes to medullary inhibition of muscle tone.. Brain research. . 1983; 268(2): 344-8.
Siegel, JM Nienhuis, R Wheeler, RL McGinty, DJ Harper, RM Discharge pattern of reticular formation unit pairs in waking and REM sleep.. Experimental neurology. . 1981; 74(3): 875-91.
Siegel, JM Wheeler, RL Breedlove, SM McGinty, DJ Brain stem units related to movements of the pinna.. Brain research. . 1980; 202(1): 183-8.
Siegel, JM Wheeler, RL McGinty, DJ Activity of medullary reticular formation neurons in the unrestrained cat during waking and sleep.. Brain research. . 1979; 179(1): 49-60.
Siegel, JM Behavioral relations of medullary reticular formation cells.. Experimental neurology. . 1979; 65(3): 691-8.
Siegel, JM Sterman, MB Ross, S Automatic detection and operant reinforcement of slow potential shifts.. Physiology & behavior. . 1979; 23(2): 411-3.
Siegel, JM Breedlove, SM McGinty, DJ Photographic analysis of relation between unit activity and movement.. Journal of neuroscience methods. . 1979; 1(2): 159-64.
Bowersox, SS Siegel, JM Sterman, MB Effects of restraint on electroencephalographic variables and monomethylhydrazine-induced seizures in the cat.. Experimental neurology. . 1978; 61(1): 154-64.
Siegel, JM McGinty, DJ Breedlove, SM Sleep and waking activity of pontine gigantocellular field neurons.. Experimental neurology. . 1977; 56(3): 553-73.
Siegel, JM McGinty, DJ Pontine reticular formation neurons: relationship of discharge to motor activity.. Science. . 1977; 196(4290): 678-80.
Siegel, JM REM sleep predicts subsequent food intake.. Physiology & behavior. . 1975; 15(5): 399-403.
Siegel, JM A stereotaxic map of the bony tentorium of the cat.. Physiology & behavior. . 1974; 13(5): 715-7.
Siegel, JM Coleman, PD Riesen, AH Pattern evoked response deficiency in pattern deprived cats.. Electroencephalography and clinical neurophysiology. . 1973; 35(6): 569-73.
Zeigler, HP Green, HL Siegel, J Food and water intake and weight regulation in the pigeon.. Physiology & behavior. . 1972; 8(1): 127-34.
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