Daniel Geschwind
Dr. Daniel Geschwind holds the Gordon and Virginia MacDonald Distinguished Chair in Human Genetics and is a professor of Neurology and Psychiatry at the UCLA School of Medicine. He is director of the Neurogenetics Program and the Center for Autism Research and Treatment (CART) and co-director of the Center for Neurobehavioral Genetics.
Dr. Geschwind obtained an A.B. in psychology and chemistry at Dartmouth College and his M.D./Ph.D. at Yale School of Medicine, prior to completing his internship, residency, and postdoctoral fellowship at UCLA. He joined the UCLA faculty in 1997.
Dr. Geschwind's laboratory conducts research in three primary areas of neurogenetics: autism and language; focal neurodegenerative syndromes; and the structural/molecular basis of human cognitive specializations. Utilizing a multi-pronged approach, he studies normal human and animal model brain patterning to diseases in which language and social communication are disrupted, such as autism. His laboratory has forged important collaborations with investigators to use evolutionary comparisons to further the genetic evaluation of human brain development and patterning, including work with songbirds and non-human primates. He also provides scientific oversight for Autism Genetic Resource Exchange (AGRE), the largest collection of multiplex autism families in the world.
Dr. Geschwind has published over two hundred papers and review articles and serves as an associate editor of the Neurobiology of Disease, deputy editor of Biological Psychiatry, and is an editorial board member of several other journals including Neuron. Dr. Geschwind is active on the scientific advisory boards of the March of Dimes, Cure Autism Now Foundation (now Autism Speaks), Faculty of 1000 Medicine, and the Society for Neuroscience Program Committee. In 2004, Dr. Geschwind received the Derek Denny-Brown Neurological Scholar Award from the American Neurological Association and in 2011 was inducted into the Institute of Medicine (IOM) of the National Academies.
Contact information
Mailing Address:
Laboratory
695 Charles E Young Dr South
Los Angeles, CA 90095
UNITED STATES
Office Address:
Office
695 Charles E Young Dr South
Los Angeles, CA 90095
UNITED STATES
| Email: | dhg@ucla.edu |
|---|
Research Interests
|
Application of network analyses, systems biology, and integration of multiple levels of data, to molecular pathways for nervous system function in health and disease. |
Publications
Oldham, M. C. Geschwind, D. H. Comparative genomics: grasping human transcriptome evolution: what does it all mean?.
Heredity.
2006; 96(5):
339-40.
Oldham, M. C. Geschwind, D. H. Deconstructing language by comparative gene expression: from neurobiology to microarray.
Genes Brain Behav.
2006; 5 Suppl 1:
54-63.
Lobo, M. K. Karsten, S. L. Gray, M. Geschwind, D. H. Yang, X. W. FACS-array profiling of striatal projection neuron subtypes in juvenile and adult mouse brains.
Nat Neurosci.
2006; 9(3):
443-52.
Chen, G. K. Kono, N. Geschwind, D. H. Cantor, R. M. Quantitative trait locus analysis of nonverbal communication in autism spectrum disorder.
Mol Psychiatry.
2006; 11(2):
214-20.
Ylisaukko-oja, T. Alarcon, M. Cantor, R. M. Auranen, M. Vanhala, R. Kempas, E. von Wendt, L. Jarvela, I. Geschwind, D. H. Peltonen, L. Search for autism loci by combined analysis of Autism Genetic Resource Exchange and Finnish families.
Ann Neurol.
2006; 59(1):
145-55.
Oldham, M. C. Geschwind, D. H. Evolutionary genetics: the human brain -- adaptation at many levels.
Eur J Hum Genet.
2005; 13(5):
520-2.
Alarcon, M. Yonan, A. L. Gilliam, T. C. Cantor, R. M. Geschwind, D. H. Quantitative genome scan and Ordered-Subsets Analysis of autism endophenotypes support language QTLs.
Mol Psychiatry.
2005; 10(8):
747-57.
Cantor, R. M. Kono, N. Duvall, J. A. Alvarez-Retuerto, A. Stone, J. L. Alarcon, M. Nelson, S. F. Geschwind, D. H. Replication of autism linkage: fine-mapping peak at 17q21.
Am J Hum Genet.
2005; 76(6):
1050-6.
Assal, F. Alarcon, M. Solomon, E. C. Masterman, D. Geschwind, D. H. Cummings, J. L. Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease.
Arch Neurol.
2004; 61(8):
1249-53.
Stone, J. L. Merriman, B. Cantor, R. M. Yonan, A. L. Gilliam, T. C. Geschwind, D. H. Nelson, S. F. Evidence for sex-specific risk alleles in autism spectrum disorder.
Am J Hum Genet.
2004; 75(6):
1117-23.
Geschwind, D. GENSAT: a genomic resource for neuroscience research.
Lancet Neurol.
2004; 3(2):
82.
Preuss, T. M. Caceres, M. Oldham, M. C. Geschwind, D. H. Human brain evolution: insights from microarrays.
Nat Rev Genet.
2004; 5(11):
850-60.
Yonan, A. L. Alarcon, M. Cheng, R. Magnusson, P. K. Spence, S. J. Palmer, A. A. Grunn, A. Juo, S. H. Terwilliger, J. D. Liu, J. Cantor, R. M. Geschwind, D. H. Gilliam, T. C. A genomewide screen of 345 families for autism-susceptibility loci.
Am J Hum Genet.
2003; 73(4):
886-97.
Geschwind, D. H. DNA microarrays: translation of the genome from laboratory to clinic.
Lancet Neurol.
2003; 2(5):
275-82.
Sobrido, M. J. Miller, B. L. Havlioglu, N. Zhukareva, V. Jiang, Z. Nasreddine, Z. S. Lee, V. M. Chow, T. W. Wilhelmsen, K. C. Cummings, J. L. Wu, J. Y. Geschwind, D. H. Novel tau polymorphisms, tau haplotypes, and splicing in familial and sporadic frontotemporal dementia.
Arch Neurol.
2003; 60(5):
698-702.
Alarcon M, Cantor RM, Liu J, Gilliam TC, the Autism Genetic Resource Exchange Consortium, Geschwind DH Evidence for a language quantitative trait locus on chromosome 7q in multiplex autism families..
Am. J. Human Genetics
2002; 70:
60-71.
Sabatti, C. Karsten, S. L. Geschwind, D. H. Thresholding rules for recovering a sparse signal from microarray experiments.
Math Biosci.
2002; 176(1):
17-34.
Geschwind, D. H. Ou, J. Easterday, M. C. Dougherty, J. D. Jackson, R. L. Chen, Z. Antoine, H. Terskikh, A. Weissman, I. L. Nelson, S. F. Kornblum, H. I. A genetic analysis of neural progenitor differentiation.
Neuron.
2001; 29(2):
325-39.
Liu, J. Nyholt, D. R. Magnussen, P. Parano, E. Pavone, P. Geschwind, D. Lord, C. Iversen, P. Hoh, J. Ott, J. Gilliam, T. C. A genomewide screen for autism susceptibility loci.
Am J Hum Genet.
2001; 69(2):
327-40.
Wilhelmsen, K. C. Miller, B. Geschwind, D. Commentary.
Neurobiol Aging.
2001; 22(1):
119-21.
Geschwind, D. H. Robidoux, J. Alarcon, M. Miller, B. L. Wilhelmsen, K. C. Cummings, J. L. Nasreddine, Z. S. Dementia and neurodevelopmental predisposition: cognitive dysfunction in presymptomatic subjects precedes dementia by decades in frontotemporal dementia.
Ann Neurol.
2001; 50(6):
741-6.
Kornblum, H. I. Geschwind, D. H. Molecular markers in CNS stem cell research: hitting a moving target.
Nat Rev Neurosci.
2001; 2(11):
843-6.
Cholfin, J. A. Sobrido, M. J. Perlman, S. Pulst, S. M. Geschwind, D. H. The SCA12 mutation as a rare cause of spinocerebellar ataxia.
Arch Neurol.
2001; 58(11):
1833-5.
Geschwind, D. H. Sowinski, J. Lord, C. Iversen, P. Shestack, J. Jones, P. Ducat, L. Spence, S. J. The autism genetic resource exchange: a resource for the study of autism and related neuropsychiatric conditions.
Am J Hum Genet.
2001; 69(2):
463-6.
Kornblum, H. Geschwind, D. The use of representational difference analysis and cDNA microarrays in neural repair research.
Restor Neurol Neurosci.
2001; 18(2-3):
89-94.
Geschwind, D. H. Boone, K. B. Miller, B. L. Swerdloff, R. S. Neurobehavioral phenotype of Klinefelter syndrome.
Ment Retard Dev Disabil Res Rev.
2000; 6(2):
107-16.
Geschwind, D. H. Loginov, M. Stern, J. M. Identification of a locus on chromosome 14q for idiopathic basal ganglia calcification (Fahr disease).
Am J Hum Genet.
1999; 65(3):
764-72.
Wilhelmsen, K. C. Clark, L. N. Miller, B. L. Geschwind, D. H. Tau mutations in frontotemporal dementia.
Dement Geriatr Cogn Disord.
1999; 10 Suppl 1:
88-92.
Geschwind, D. H. Gregg, J. Boone, K. Karrim, J. Pawlikowska-Haddal, A. Rao, E. Ellison, J. Ciccodicola, A. D'Urso, M. Woods, R. Rappold, G. A. Swerdloff, R. Nelson, S. F. Klinefelter's syndrome as a model of anomalous cerebral laterality: testing gene dosage in the X chromosome pseudoautosomal region using a DNA microarray.
Dev Genet.
1998; 23(3):
215-29.
Geschwind, D. Karrim, J. Nelson, S. F. Miller, B. The apolipoprotein E epsilon4 allele is not a significant risk factor for frontotemporal dementia.
Ann Neurol.
1998; 44(1):
134-8.
Geschwind, D. H. Perlman, S. Figueroa, C. P. Treiman, L. J. Pulst, S. M. The prevalence and wide clinical spectrum of the spinocerebellar ataxia type 2 trinucleotide repeat in patients with autosomal dominant cerebellar ataxia.
Am J Hum Genet.
1997; 60(4):
842-50.
Geschwind, D. H. Rhee, R. Nelson, S. F. A biotinylated MutS fusion protein and its use in a rapid mutation screening technique.
Genet Anal.
1996; 13(4):
105-11.
Geschwind, D. H. Thormodsson, F. R. Hockfield, S. Changes in protein expression during neural development analyzed by two-dimensional gel electrophoresis.
Electrophoresis.
1996; 17(11):
1677-82.
Geschwind, D. H. Iacoboni, M. Mega, M. S. Zaidel, D. W. Cloughesy, T. Zaidel, E. Alien hand syndrome: interhemispheric motor disconnection due to a lesion in the midbody of the corpus callosum.
Neurology.
1995; 45(4):
802-8.
Minturn, J. E. Fryer, H. J. Geschwind, D. H. Hockfield, S. TOAD-64, a gene expressed early in neuronal differentiation in the rat, is related to unc-33, a C. elegans gene involved in axon outgrowth.
J Neurosci.
1995; 15(10):
6757-66.
Lidow, M. S. Goldman-Rakic, P. S. Gallager, D. W. Geschwind, D. H. Rakic, P. Distribution of major neurotransmitter receptors in the motor and somatosensory cortex of the rhesus monkey.
Neuroscience.
1989; 32(3):
609-27.
Geschwind, D. H. Hockfield, S. Identification of proteins that are developmentally regulated during early cerebral corticogenesis in the rat.
J Neurosci.
1989; 9(12):
4303-17.
Braskie Meredith N, Medina Luis D, Rodriguez-Agudelo Yaneth, Geschwind Daniel H, Macias-Islas Miguel Angel, Cummings Jeffrey L, Bookheimer Susan Y, Ringman John M Increased fMRI signal with age in familial Alzheimer's disease
mutation carriers..
Neurobiology of aging.
2012; 33(2):
424.e11-21.
Fogel Brent L, Lee Ji Yong, Lane Jessica, Wahnich Amanda, Chan Sandy, Huang Alden, Osborn Greg E, Klein Eric, Mamah Catherine, Perlman Susan, Geschwind Daniel H, Coppola Giovanni Mutations in rare ataxia genes are uncommon causes of sporadic
cerebellar ataxia..
Movement disorders : official journal of the Movement Disorder Society.
2012; 33(2):
.
Ringman John M, Schulman Howard, Becker Chris, Jones Ted, Bai Yuchen, Immermann Fred, Cole Gregory, Sokolow Sophie, Gylys Karen, Geschwind Daniel H, Cummings Jeffrey L, Wan Hong I Proteomic changes in cerebrospinal fluid of presymptomatic and
affected persons carrying familial Alzheimer disease mutations..
Archives of neurology.
2012; 69(1):
96-104.
Paşca Sergiu P, Portmann Thomas, Voineagu Irina, Yazawa Masayuki, Shcheglovitov Aleksandr, Paşca Anca M, Cord Branden, Palmer Theo D, Chikahisa Sachiko, Nishino Seiji, Bernstein Jonathan A, Hallmayer Joachim, Geschwind Daniel H, Dolmetsch Ricardo E Using iPSC-derived neurons to uncover cellular phenotypes associated
with Timothy syndrome..
Nature medicine.
2011; 17(12):
1657-62.
Coppola Giovanni, Burnett Ryan, Perlman Susan, Versano Revital, Gao Fuying, Plasterer Heather, Rai Myriam, Saccá Francesco, Filla Alessandro, Lynch David R, Rusche James R, Gottesfeld Joel M, Pandolfo Massimo, Geschwind Daniel H A gene expression phenotype in lymphocytes from Friedreich ataxia
patients..
Annals of neurology.
2011; 70(5):
790-804.
Wexler Eric M, Geschwind Daniel H DISC1: a schizophrenia gene with multiple personalities..
Neuron.
2011; 72(4):
501-3.
Casey Jillian P, Magalhaes Tiago, Conroy Judith M, Regan Regina, Shah Naisha, Anney Richard, Shields Denis C, Abrahams Brett S, Almeida Joana, Bacchelli Elena, Bailey Anthony J, Baird Gillian, Battaglia Agatino, Berney Tom, Bolshakova Nadia, Bolton Patrick F, Bourgeron Thomas, Brennan Sean, Cali Phil, Correia Catarina, Corsello Christina, Coutanche Marc, Dawson Geraldine, de Jonge Maretha, Delorme Richard, Duketis Eftichia, Duque Frederico, Estes Annette, Farrar Penny, Fernandez Bridget A, Folstein Susan E, Foley Suzanne, Fombonne Eric, Freitag Christine M, Gilbert John, Gillberg Christopher, Glessner Joseph T, Green Jonathan, Guter Stephen J, Hakonarson Hakon, Holt Richard, Hughes Gillian, Hus Vanessa, Igliozzi Roberta, Kim Cecilia, Klauck Sabine M, Kolevzon Alexander, Lamb Janine A, Leboyer Marion, Le Couteur Ann, Leventhal Bennett L, Lord Catherine, Lund Sabata C, Maestrini Elena, Mantoulan Carine, Marshall Christian R, McConachie Helen, McDougle Christopher J, McGrath Jane, McMahon William M, Merikangas Alison, Miller Judith, Minopoli Fiorella, Mirza Ghazala K, Munson Jeff, Nelson Stanley F, Nygren Gudrun, Oliveira Guiomar, Pagnamenta Alistair T, Papanikolaou Katerina, Parr Jeremy R, Parrini Barbara, Pickles Andrew, Pinto Dalila, Piven Joseph, Posey David J, Poustka Annemarie, Poustka Fritz, Ragoussis Jiannis, Roge Bernadette, Rutter Michael L, Sequeira Ana F, Soorya Latha, Sousa Inês, Sykes Nuala, Stoppioni Vera, Tancredi Raffaella, Tauber Maïté, Thompson Ann P, Thomson Susanne, Tsiantis John, Van Engeland Herman, Vincent John B, Volkmar Fred, Vorstman Jacob A S, Wallace Simon, Wang Kai, Wassink Thomas H, White Kathy, Wing Kirsty, Wittemeyer Kerstin, Yaspan Brian L, Zwaigenbaum Lonnie, Betancur Catalina, Buxbaum Joseph D, Cantor Rita M, Cook Edwin H, Coon Hilary, Cuccaro Michael L, Geschwind Daniel H, Haines Jonathan L, Hallmayer Joachim, Monaco Anthony P, Nurnberger John I, Pericak-Vance Margaret A, Schellenberg Gerard D, Scherer Stephen W, Sutcliffe James S, Szatmari Peter, Vieland Veronica J, Wijsman Ellen M, Green Andrew, Gill Michael, Gallagher Louise, Vicente Astrid, Ennis Sean A novel approach of homozygous haplotype sharing identifies candidate
genes in autism spectrum disorder..
Human genetics.
2011; 72(2):
.
DeJesus-Hernandez Mariely, Mackenzie Ian R, Boeve Bradley F, Boxer Adam L, Baker Matt, Rutherford Nicola J, Nicholson Alexandra M, Finch NiCole A, Flynn Heather, Adamson Jennifer, Kouri Naomi, Wojtas Aleksandra, Sengdy Pheth, Hsiung Ging-Yuek R, Karydas Anna, Seeley William W, Josephs Keith A, Coppola Giovanni, Geschwind Daniel H, Wszolek Zbigniew K, Feldman Howard, Knopman David S, Petersen Ronald C, Miller Bruce L, Dickson Dennis W, Boylan Kevin B, Graff-Radford Neill R, Rademakers Rosa Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72
causes chromosome 9p-linked FTD and ALS..
Neuron.
2011; 72(2):
245-56.
Wexler Eric M, Rosen Ezra, Lu Daning, Osborn Gregory E, Martin Elizabeth, Raybould Helen, Geschwind Daniel H Genome-wide analysis of a Wnt1-regulated transcriptional network
implicates neurodegenerative pathways..
Science signaling.
2011; 4(193):
ra65.
Peñagarikano Olga, Abrahams Brett S, Herman Edward I, Winden Kellen D, Gdalyahu Amos, Dong Hongmei, Sonnenblick Lisa I, Gruver Robin, Almajano Joel, Bragin Anatol, Golshani Peyman, Trachtenberg Joshua T, Peles Elior, Geschwind Daniel H Absence of CNTNAP2 leads to epilepsy, neuronal migration
abnormalities, and core autism-related deficits..
Cell.
2011; 147(1):
235-46.
Rosen Ezra Y, Wexler Eric M, Versano Revital, Coppola Giovanni, Gao Fuying, Winden Kellen D, Oldham Michael C, Martens Lauren Herl, Zhou Ping, Farese Robert V, Geschwind Daniel H Functional genomic analyses identify pathways dysregulated by
progranulin deficiency, implicating Wnt signaling..
Neuron.
2011; 71(6):
1030-42.
Geschwind Daniel H Genetics of autism spectrum disorders..
Trends in cognitive sciences.
2011; 15(9):
409-16.
Mukamel Zohar, Konopka Genevieve, Wexler Eric, Osborn Gregory E, Dong Hongmei, Bergman Mica Y, Levitt Pat, Geschwind Daniel H Regulation of MET by FOXP2, genes implicated in higher cognitive
dysfunction and autism risk..
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2011; 31(32):
11437-42.
Miller Jeremy A, Cai Chaochao, Langfelder Peter, Geschwind Daniel H, Kurian Sunil M, Salomon Daniel R, Horvath Steve Strategies for aggregating gene expression data: the collapseRows R
function..
BMC bioinformatics.
2011; 12(32):
322.
Vernes Sonja C, Oliver Peter L, Spiteri Elizabeth, Lockstone Helen E, Puliyadi Rathi, Taylor Jennifer M, Ho Joses, Mombereau Cedric, Brewer Ariel, Lowy Ernesto, Nicod Jérôme, Groszer Matthias, Baban Dilair, Sahgal Natasha, Cazier Jean-Baptiste, Ragoussis Jiannis, Davies Kay E, Geschwind Daniel H, Fisher Simon E Foxp2 regulates gene networks implicated in neurite outgrowth in the
developing brain..
PLoS genetics.
2011; 7(7):
e1002145.
Becker Esther B E, Fogel Brent L, Rajakulendran Sanjeev, Dulneva Anna, Hanna Michael G, Perlman Susan L, Geschwind Daniel H, Davies Kay E Candidate screening of the TRPC3 gene in cerebellar ataxia..
Cerebellum (London, England).
2011; 10(2):
296-9.
Tang Bin, Seredenina Tamara, Coppola Giovanni, Kuhn Alexandre, Geschwind Daniel H, Luthi-Carter Ruth, Thomas Elizabeth A Gene expression profiling of R6/2 transgenic mice with different CAG
repeat lengths reveals genes associated with disease onset and
progression in Huntington's disease..
Neurobiology of disease.
2011; 42(3):
459-67.
Sanders Stephan J, Ercan-Sencicek A Gulhan, Hus Vanessa, Luo Rui, Murtha Michael T, Moreno-De-Luca Daniel, Chu Su H, Moreau Michael P, Gupta Abha R, Thomson Susanne A, Mason Christopher E, Bilguvar Kaya, Celestino-Soper Patricia B S, Choi Murim, Crawford Emily L, Davis Lea, Wright Nicole R Davis, Dhodapkar Rahul M, DiCola Michael, DiLullo Nicholas M, Fernandez Thomas V, Fielding-Singh Vikram, Fishman Daniel O, Frahm Stephanie, Garagaloyan Rouben, Goh Gerald S, Kammela Sindhuja, Klei Lambertus, Lowe Jennifer K, Lund Sabata C, McGrew Anna D, Meyer Kyle A, Moffat William J, Murdoch John D, O'Roak Brian J, Ober Gordon T, Pottenger Rebecca S, Raubeson Melanie J, Song Youeun, Wang Qi, Yaspan Brian L, Yu Timothy W, Yurkiewicz Ilana R, Beaudet Arthur L, Cantor Rita M, Curland Martin, Grice Dorothy E, Günel Murat, Lifton Richard P, Mane Shrikant M, Martin Donna M, Shaw Chad A, Sheldon Michael, Tischfield Jay A, Walsh Christopher A, Morrow Eric M, Ledbetter David H, Fombonne Eric, Lord Catherine, Martin Christa Lese, Brooks Andrew I, Sutcliffe James S, Cook Edwin H, Geschwind Daniel, Roeder Kathryn, Devlin Bernie, State Matthew W Multiple recurrent de novo CNVs, including duplications of the 7q11.23
Williams syndrome region, are strongly associated with autism..
Neuron.
2011; 70(5):
863-85.
Dolmetsch Ricardo, Geschwind Daniel H The human brain in a dish: the promise of iPSC-derived neurons..
Cell.
2011; 145(6):
831-4.
Voineagu Irina, Wang Xinchen, Johnston Patrick, Lowe Jennifer K, Tian Yuan, Horvath Steve, Mill Jonathan, Cantor Rita M, Blencowe Benjamin J, Geschwind Daniel H Transcriptomic analysis of autistic brain reveals convergent molecular
pathology..
Nature.
2011; 474(7351):
380-4.
Naj Adam C, Jun Gyungah, Beecham Gary W, Wang Li-San, Vardarajan Badri Narayan, Buros Jacqueline, Gallins Paul J, Buxbaum Joseph D, Jarvik Gail P, Crane Paul K, Larson Eric B, Bird Thomas D, Boeve Bradley F, Graff-Radford Neill R, De Jager Philip L, Evans Denis, Schneider Julie A, Carrasquillo Minerva M, Ertekin-Taner Nilufer, Younkin Steven G, Cruchaga Carlos, Kauwe John S K, Nowotny Petra, Kramer Patricia, Hardy John, Huentelman Matthew J, Myers Amanda J, Barmada Michael M, Demirci F Yesim, Baldwin Clinton T, Green Robert C, Rogaeva Ekaterina, St George-Hyslop Peter, Arnold Steven E, Barber Robert, Beach Thomas, Bigio Eileen H, Bowen James D, Boxer Adam, Burke James R, Cairns Nigel J, Carlson Chris S, Carney Regina M, Carroll Steven L, Chui Helena C, Clark David G, Corneveaux Jason, Cotman Carl W, Cummings Jeffrey L, DeCarli Charles, DeKosky Steven T, Diaz-Arrastia Ramon, Dick Malcolm, Dickson Dennis W, Ellis William G, Faber Kelley M, Fallon Kenneth B, Farlow Martin R, Ferris Steven, Frosch Matthew P, Galasko Douglas R, Ganguli Mary, Gearing Marla, Geschwind Daniel H, Ghetti Bernardino, Gilbert John R, Gilman Sid, Giordani Bruno, Glass Jonathan D, Growdon John H, Hamilton Ronald L, Harrell Lindy E, Head Elizabeth, Honig Lawrence S, Hulette Christine M, Hyman Bradley T, Jicha Gregory A, Jin Lee-Way, Johnson Nancy, Karlawish Jason, Karydas Anna, Kaye Jeffrey A, Kim Ronald, Koo Edward H, Kowall Neil W, Lah James J, Levey Allan I, Lieberman Andrew P, Lopez Oscar L, Mack Wendy J, Marson Daniel C, Martiniuk Frank, Mash Deborah C, Masliah Eliezer, McCormick Wayne C, McCurry Susan M, McDavid Andrew N, McKee Ann C, Mesulam Marsel, Miller Bruce L, Miller Carol A, Miller Joshua W, Parisi Joseph E, Perl Daniel P, Peskind Elaine, Petersen Ronald C, Poon Wayne W, Quinn Joseph F, Rajbhandary Ruchita A, Raskind Murray, Reisberg Barry, Ringman John M, Roberson Erik D, Rosenberg Roger N, Sano Mary, Schneider Lon S, Seeley William, Shelanski Michael L, Slifer Michael A, Smith Charles D, Sonnen Joshua A, Spina Salvatore, Stern Robert A, Tanzi Rudolph E, Trojanowski John Q, Troncoso Juan C, Van Deerlin Vivianna M, Vinters Harry V, Vonsattel Jean Paul, Weintraub Sandra, Welsh-Bohmer Kathleen A, Williamson Jennifer, Woltjer Randall L, Cantwell Laura B, Dombroski Beth A, Beekly Duane, Lunetta Kathryn L, Martin Eden R, Kamboh M Ilyas, Saykin Andrew J, Reiman Eric M, Bennett David A, Morris John C, Montine Thomas J, Goate Alison M, Blacker Deborah, Tsuang Debby W, Hakonarson Hakon, Kukull Walter A, Foroud Tatiana M, Haines Jonathan L, Mayeux Richard, Pericak-Vance Margaret A, Farrer Lindsay A, Schellenberg Gerard D Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated
with late-onset Alzheimer's disease..
Nature genetics.
2011; 43(5):
436-41.
Juknat Ana, Pietr Maciej, Kozela Ewa, Rimmerman Neta, Levy Rivka, Coppola Giovanni, Geschwind Daniel, Vogel Zvi Differential transcriptional profiles mediated by exposure to the
cannabinoids cannabidiol and Δ(9) -tetrahydrocannabinol in BV-2
microglial cells..
British journal of pharmacology.
2011; 286(18):
.
Sleiman Sama F, Langley Brett C, Basso Manuela, Berlin Jill, Xia Li, Payappilly Jimmy B, Kharel Madan K, Guo Hengchang, Marsh J Lawrence, Thompson Leslie Michels, Mahishi Lata, Ahuja Preeti, MacLellan W Robb, Geschwind Daniel H, Coppola Giovanni, Rohr Jürgen, Ratan Rajiv R Mithramycin is a gene-selective Sp1 inhibitor that identifies a
biological intersection between cancer and neurodegeneration..
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2011; 31(18):
6858-70.
Iwamoto Kazuya, Bundo Miki, Ueda Junko, Oldham Michael C, Ukai Wataru, Hashimoto Eri, Saito Toshikazu, Geschwind Daniel H, Kato Tadafumi Neurons show distinctive DNA methylation profile and higher
interindividual variations compared with non-neurons..
Genome research.
2011; 21(5):
688-96.
Cenik Basar, Sephton Chantelle F, Dewey Colleen M, Xian Xunde, Wei Shuguang, Yu Kimberley, Niu Wenze, Coppola Giovanni, Coughlin Sarah E, Lee Suzee E, Dries Daniel R, Almeida Sandra, Geschwind Daniel H, Gao Fen-Biao, Miller Bruce L, Farese Robert V, Posner Bruce A, Yu Gang, Herz Joachim Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin
transcription: rational therapeutic approach to frontotemporal
dementia..
The Journal of biological chemistry.
2011; 286(18):
16101-8.
Ringman John M, Medina Luis D, Braskie Meredith, Rodriguez-Agudelo Yaneth, Geschwind Daniel H, Macias-Islas Miguel A, Cummings Jeffrey L, Bookheimer Susan Effects of risk genes on BOLD activation in presymptomatic carriers of
familial Alzheimer's disease mutations during a novelty encoding task..
Cerebral cortex (New York, N.Y. : 1991).
2011; 21(4):
877-83.
Zai Laila, Ferrari Christina, Dice Carlie, Subbaiah Sathish, Havton Leif A, Coppola Giovanni, Geschwind Daniel, Irwin Nina, Huebner Eric, Strittmatter Stephen M, Benowitz Larry I Inosine augments the effects of a Nogo receptor blocker and of
environmental enrichment to restore skilled forelimb use after stroke..
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2011; 31(16):
5977-88.
Geschwind Daniel H Neurodevelopmental disorders: hope for a new beginning..
Current opinion in neurology.
2011; 24(2):
95-7.
Thomas Elizabeth A, Coppola Giovanni, Tang Bin, Kuhn Alexandre, Kim SoongHo, Geschwind Daniel H, Brown Timothy B, Luthi-Carter Ruth, Ehrlich Michelle E In vivo cell-autonomous transcriptional abnormalities revealed in mice
expressing mutant huntingtin in striatal but not cortical neurons..
Human molecular genetics.
2011; 20(6):
1049-60.
Marques Fernanda, Sousa João C, Coppola Giovanni, Gao Fuying, Puga Renato, Brentani Helena, Geschwind Daniel H, Sousa Nuno, Correia-Neves Margarida, Palha Joana A Transcriptome signature of the adult mouse choroid plexus..
Fluids and barriers of the CNS.
2011; 8(1):
10.
Winden Kellen D, Karsten Stanislav L, Bragin Anatol, Kudo Lili C, Gehman Lauren, Ruidera Josephine, Geschwind Daniel H, Engel Jerome A systems level, functional genomics analysis of chronic epilepsy..
PloS one.
2011; 6(6):
e20763.
Lu Po H, Thompson Paul M, Leow Alex, Lee Grace J, Lee Agatha, Yanovsky Igor, Parikshak Neelroop, Khoo Theresa, Wu Stephanie, Geschwind Daniel, Bartzokis George Apolipoprotein E genotype is associated with temporal and hippocampal
atrophy rates in healthy elderly adults: a tensor-based morphometry
study..
Journal of Alzheimer's disease : JAD.
2011; 23(3):
433-42.
Apostolova Liana G, Hwang Kristy S, Medina Luis D, Green Amity E, Braskie Meredith N, Dutton Rebecca A, Lai Jeffrey, Geschwind Daniel H, Cummings Jeffrey L, Thompson Paul M, Ringman John M Cortical and hippocampal atrophy in patients with autosomal dominant
familial Alzheimer's disease..
Dementia and geriatric cognitive disorders.
2011; 32(2):
118-25.
Medina Luis D, Rodriguez-Agudelo Yaneth, Geschwind Daniel H, Gilbert Paul E, Liang Li-Jung, Cummings Jeffrey L, Ringman John M Propositional density and apolipoprotein E genotype among persons at
risk for familial Alzheimer's disease..
Dementia and geriatric cognitive disorders.
2011; 32(3):
188-92.
Newbern Jason M, Li Xiaoyan, Shoemaker Sarah E, Zhou Jiang, Zhong Jian, Wu Yaohong, Bonder Daniel, Hollenback Steven, Coppola Giovanni, Geschwind Daniel H, Landreth Gary E, Snider William D Specific functions for ERK/MAPK signaling during PNS development..
Neuron.
2011; 69(1):
91-105.
Li Songlin, Overman Justine J, Katsman Diana, Kozlov Serguei V, Donnelly Christopher J, Twiss Jeffery L, Giger Roman J, Coppola Giovanni, Geschwind Daniel H, Carmichael S Thomas An age-related sprouting transcriptome provides molecular control of
axonal sprouting after stroke..
Nature neuroscience.
2010; 13(12):
1496-504.
Scott-Van Zeeland Ashley A, Abrahams Brett S, Alvarez-Retuerto Ana I, Sonnenblick Lisa I, Rudie Jeffrey D, Ghahremani Dara, Mumford Jeanette A, Poldrack Russell A, Dapretto Mirella, Geschwind Daniel H, Bookheimer Susan Y Altered functional connectivity in frontal lobe circuits is associated
with variation in the autism risk gene CNTNAP2..
Science translational medicine.
2010; 2(56):
56ra80.
Wang Su, Chandler-Militello Devin, Lu Gang, Roy Neeta S, Zielke Alex, Auvergne Romane, Stanwood Nancy, Geschwind Daniel, Coppola Giovanni, Nicolis Silvia K, Sim Fraser J, Goldman Steven A Prospective identification, isolation, and profiling of a
telomerase-expressing subpopulation of human neural stem cells, using
sox2 enhancer-directed fluorescence-activated cell sorting..
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2010; 30(44):
14635-48.
Anney Richard, Klei Lambertus, Pinto Dalila, Regan Regina, Conroy Judith, Magalhaes Tiago R, Correia Catarina, Abrahams Brett S, Sykes Nuala, Pagnamenta Alistair T, Almeida Joana, Bacchelli Elena, Bailey Anthony J, Baird Gillian, Battaglia Agatino, Berney Tom, Bolshakova Nadia, Bölte Sven, Bolton Patrick F, Bourgeron Thomas, Brennan Sean, Brian Jessica, Carson Andrew R, Casallo Guillermo, Casey Jillian, Chu Su H, Cochrane Lynne, Corsello Christina, Crawford Emily L, Crossett Andrew, Dawson Geraldine, de Jonge Maretha, Delorme Richard, Drmic Irene, Duketis Eftichia, Duque Frederico, Estes Annette, Farrar Penny, Fernandez Bridget A, Folstein Susan E, Fombonne Eric, Freitag Christine M, Gilbert John, Gillberg Christopher, Glessner Joseph T, Goldberg Jeremy, Green Jonathan, Guter Stephen J, Hakonarson Hakon, Heron Elizabeth A, Hill Matthew, Holt Richard, Howe Jennifer L, Hughes Gillian, Hus Vanessa, Igliozzi Roberta, Kim Cecilia, Klauck Sabine M, Kolevzon Alexander, Korvatska Olena, Kustanovich Vlad, Lajonchere Clara M, Lamb Janine A, Laskawiec Magdalena, Leboyer Marion, Le Couteur Ann, Leventhal Bennett L, Lionel Anath C, Liu Xiao-Qing, Lord Catherine, Lotspeich Linda, Lund Sabata C, Maestrini Elena, Mahoney William, Mantoulan Carine, Marshall Christian R, McConachie Helen, McDougle Christopher J, McGrath Jane, McMahon William M, Melhem Nadine M, Merikangas Alison, Migita Ohsuke, Minshew Nancy J, Mirza Ghazala K, Munson Jeff, Nelson Stanley F, Noakes Carolyn, Noor Abdul, Nygren Gudrun, Oliveira Guiomar, Papanikolaou Katerina, Parr Jeremy R, Parrini Barbara, Paton Tara, Pickles Andrew, Piven Joseph, Posey David J, Poustka Annemarie, Poustka Fritz, Prasad Aparna, Ragoussis Jiannis, Renshaw Katy, Rickaby Jessica, Roberts Wendy, Roeder Kathryn, Roge Bernadette, Rutter Michael L, Bierut Laura J, Rice John P, Salt Jeff, Sansom Katherine, Sato Daisuke, Segurado Ricardo, Senman Lili, Shah Naisha, Sheffield Val C, Soorya Latha, Sousa Inês, Stoppioni Vera, Strawbridge Christina, Tancredi Raffaella, Tansey Katherine, Thiruvahindrapduram Bhooma, Thompson Ann P, Thomson Susanne, Tryfon Ana, Tsiantis John, Van Engeland Herman, Vincent John B, Volkmar Fred, Wallace Simon, Wang Kai, Wang Zhouzhi, Wassink Thomas H, Wing Kirsty, Wittemeyer Kerstin, Wood Shawn, Yaspan Brian L, Zurawiecki Danielle, Zwaigenbaum Lonnie, Betancur Catalina, Buxbaum Joseph D, Cantor Rita M, Cook Edwin H, Coon Hilary, Cuccaro Michael L, Gallagher Louise, Geschwind Daniel H, Gill Michael, Haines Jonathan L, Miller Judith, Monaco Anthony P, Nurnberger John I, Paterson Andrew D, Pericak-Vance Margaret A, Schellenberg Gerard D, Scherer Stephen W, Sutcliffe James S, Szatmari Peter, Vicente Astrid M, Vieland Veronica J, Wijsman Ellen M, Devlin Bernie, Ennis Sean, Hallmayer Joachim A genome-wide scan for common alleles affecting risk for autism..
Human molecular genetics.
2010; 19(20):
4072-82.
Mumford Jeanette A, Horvath Steve, Oldham Michael C, Langfelder Peter, Geschwind Daniel H, Poldrack Russell A Detecting network modules in fMRI time series: a weighted network
analysis approach..
NeuroImage.
2010; 52(4):
1465-76.
Konopka Genevieve, Geschwind Daniel H Human brain evolution: harnessing the genomics (r)evolution to link
genes, cognition, and behavior..
Neuron.
2010; 68(2):
231-44.
McConoughey Stephen J, Basso Manuela, Niatsetskaya Zoya V, Sleiman Sama F, Smirnova Natalia A, Langley Brett C, Mahishi Lata, Cooper Arthur J L, Antonyak Marc A, Cerione Rick A, Li Bo, Starkov Anatoly, Chaturvedi Rajnish Kumar, Beal M Flint, Coppola Giovanni, Geschwind Daniel H, Ryu Hoon, Xia Li, Iismaa Siiri E, Pallos Judit, Pasternack Ralf, Hils Martin, Fan Jing, Raymond Lynn A, Marsh J Lawrence, Thompson Leslie M, Ratan Rajiv R Inhibition of transglutaminase 2 mitigates transcriptional
dysregulation in models of Huntington disease..
EMBO molecular medicine.
2010; 2(9):
349-70.
Costigan Michael, Belfer Inna, Griffin Robert S, Dai Feng, Barrett Lee B, Coppola Giovanni, Wu Tianxia, Kiselycznyk Carly, Poddar Minakshi, Lu Yan, Diatchenko Luda, Smith Shad, Cobos Enrique J, Zaykin Dmitri, Allchorne Andrew, Gershon Edith, Livneh Jessica, Shen Pei-Hong, Nikolajsen Lone, Karppinen Jaro, Männikkö Minna, Kelempisioti Anthi, Goldman David, Maixner William, Geschwind Daniel H, Max Mitchell B, Seltzer Ze'ev, Woolf Clifford J Multiple chronic pain states are associated with a common amino
acid-changing allele in KCNS1..
Brain : a journal of neurology.
2010; 133(9):
2519-27.
Miller Jeremy A, Horvath Steve, Geschwind Daniel H Divergence of human and mouse brain transcriptome highlights Alzheimer
disease pathways..
Proceedings of the National Academy of Sciences of the United States of America.
2010; 107(28):
12698-703.
Pinto Dalila, Pagnamenta Alistair T, Klei Lambertus, Anney Richard, Merico Daniele, Regan Regina, Conroy Judith, Magalhaes Tiago R, Correia Catarina, Abrahams Brett S, Almeida Joana, Bacchelli Elena, Bader Gary D, Bailey Anthony J, Baird Gillian, Battaglia Agatino, Berney Tom, Bolshakova Nadia, Bölte Sven, Bolton Patrick F, Bourgeron Thomas, Brennan Sean, Brian Jessica, Bryson Susan E, Carson Andrew R, Casallo Guillermo, Casey Jillian, Chung Brian H Y, Cochrane Lynne, Corsello Christina, Crawford Emily L, Crossett Andrew, Cytrynbaum Cheryl, Dawson Geraldine, de Jonge Maretha, Delorme Richard, Drmic Irene, Duketis Eftichia, Duque Frederico, Estes Annette, Farrar Penny, Fernandez Bridget A, Folstein Susan E, Fombonne Eric, Freitag Christine M, Gilbert John, Gillberg Christopher, Glessner Joseph T, Goldberg Jeremy, Green Andrew, Green Jonathan, Guter Stephen J, Hakonarson Hakon, Heron Elizabeth A, Hill Matthew, Holt Richard, Howe Jennifer L, Hughes Gillian, Hus Vanessa, Igliozzi Roberta, Kim Cecilia, Klauck Sabine M, Kolevzon Alexander, Korvatska Olena, Kustanovich Vlad, Lajonchere Clara M, Lamb Janine A, Laskawiec Magdalena, Leboyer Marion, Le Couteur Ann, Leventhal Bennett L, Lionel Anath C, Liu Xiao-Qing, Lord Catherine, Lotspeich Linda, Lund Sabata C, Maestrini Elena, Mahoney William, Mantoulan Carine, Marshall Christian R, McConachie Helen, McDougle Christopher J, McGrath Jane, McMahon William M, Merikangas Alison, Migita Ohsuke, Minshew Nancy J, Mirza Ghazala K, Munson Jeff, Nelson Stanley F, Noakes Carolyn, Noor Abdul, Nygren Gudrun, Oliveira Guiomar, Papanikolaou Katerina, Parr Jeremy R, Parrini Barbara, Paton Tara, Pickles Andrew, Pilorge Marion, Piven Joseph, Ponting Chris P, Posey David J, Poustka Annemarie, Poustka Fritz, Prasad Aparna, Ragoussis Jiannis, Renshaw Katy, Rickaby Jessica, Roberts Wendy, Roeder Kathryn, Roge Bernadette, Rutter Michael L, Bierut Laura J, Rice John P, Salt Jeff, Sansom Katherine, Sato Daisuke, Segurado Ricardo, Sequeira Ana F, Senman Lili, Shah Naisha, Sheffield Val C, Soorya Latha, Sousa Inês, Stein Olaf, Sykes Nuala, Stoppioni Vera, Strawbridge Christina, Tancredi Raffaella, Tansey Katherine, Thiruvahindrapduram Bhooma, Thompson Ann P, Thomson Susanne, Tryfon Ana, Tsiantis John, Van Engeland Herman, Vincent John B, Volkmar Fred, Wallace Simon, Wang Kai, Wang Zhouzhi, Wassink Thomas H, Webber Caleb, Weksberg Rosanna, Wing Kirsty, Wittemeyer Kerstin, Wood Shawn, Wu Jing, Yaspan Brian L, Zurawiecki Danielle, Zwaigenbaum Lonnie, Buxbaum Joseph D, Cantor Rita M, Cook Edwin H, Coon Hilary, Cuccaro Michael L, Devlin Bernie, Ennis Sean, Gallagher Louise, Geschwind Daniel H, Gill Michael, Haines Jonathan L, Hallmayer Joachim, Miller Judith, Monaco Anthony P, Nurnberger John I, Paterson Andrew D, Pericak-Vance Margaret A, Schellenberg Gerard D, Szatmari Peter, Vicente Astrid M, Vieland Veronica J, Wijsman Ellen M, Scherer Stephen W, Sutcliffe James S, Betancur Catalina Functional impact of global rare copy number variation in autism
spectrum disorders..
Nature.
2010; 466(7304):
368-72.
Michaelevski Izhak, Segal-Ruder Yael, Rozenbaum Meir, Medzihradszky Katalin F, Shalem Ophir, Coppola Giovanni, Horn-Saban Shirley, Ben-Yaakov Keren, Dagan Shachar Y, Rishal Ida, Geschwind Daniel H, Pilpel Yitzhak, Burlingame Alma L, Fainzilber Mike Signaling to transcription networks in the neuronal retrograde injury
response..
Science signaling.
2010; 3(130):
ra53.
Panaitof S Carmen, Abrahams Brett S, Dong Hongmei, Geschwind Daniel H, White Stephanie A Language-related Cntnap2 gene is differentially expressed in sexually
dimorphic song nuclei essential for vocal learning in songbirds..
The Journal of comparative neurology.
2010; 518(11):
1995-2018.
Ziegler Lina, Segal-Ruder Yael, Coppola Giovanni, Reis Arbel, Geschwind Daniel, Fainzilber Mike, Goldstein Ronald S A human neuron injury model for molecular studies of axonal
regeneration..
Experimental neurology.
2010; 223(1):
119-27.
Hilton Claudia L, Fitzgerald Robert T, Jackson Kelley M, Maxim Rolanda A, Bosworth Christopher C, Shattuck Paul T, Geschwind Daniel H, Constantino John N Brief report: Under-representation of African americans in autism
genetic research: a rationale for inclusion of subjects representing
diverse family structures..
Journal of autism and developmental disorders.
2010; 40(5):
633-9.
Abrahams Brett S, Geschwind Daniel H Connecting genes to brain in the autism spectrum disorders..
Archives of neurology.
2010; 67(4):
395-9.
Sarafian Theodore A, Montes Cindy, Imura Tetsuya, Qi Jingwei, Coppola Giovanni, Geschwind Daniel H, Sofroniew Michael V Disruption of astrocyte STAT3 signaling decreases mitochondrial
function and increases oxidative stress in vitro..
PloS one.
2010; 5(3):
e9532.
Shoemaker Lorelei D, Orozco Nicholas M, Geschwind Daniel H, Whitelegge Julian P, Faull Kym F, Kornblum Harley I Identification of differentially expressed proteins in murine
embryonic and postnatal cortical neural progenitors..
PloS one.
2010; 5(2):
e9121.
Bartzokis George, Lu Po H, Tishler Todd A, Peters Douglas G, Kosenko Anastasia, Barrall Katherine A, Finn J Paul, Villablanca Pablo, Laub Gerhard, Altshuler Lori L, Geschwind Daniel H, Mintz Jim, Neely Elizabeth, Connor James R Prevalent iron metabolism gene variants associated with increased
brain ferritin iron in healthy older men..
Journal of Alzheimer's disease : JAD.
2010; 20(1):
333-41.
Geschwind Daniel H Autism: the ups and downs of neuroligin..
Biological psychiatry.
2009; 66(10):
904-5.
Konopka Genevieve, Bomar Jamee M, Winden Kellen, Coppola Giovanni, Jonsson Zophonias O, Gao Fuying, Peng Sophia, Preuss Todd M, Wohlschlegel James A, Geschwind Daniel H Human-specific transcriptional regulation of CNS development genes by
FOXP2..
Nature.
2009; 462(7270):
213-7.
Geschwind Daniel H, Konopka Genevieve Neuroscience in the era of functional genomics and systems biology..
Nature.
2009; 461(7266):
908-15.
Woods Diana Lynn, Bushnell Brittany, Kim Haesook, Geschwind Daniel, Cummings Jeffrey Apolipoprotein epsilon4 status is associated with behavioral symptoms
in nursing home residents with dementia..
International psychogeriatrics / IPA.
2009; 21(4):
722-8.
Criscuolo Chiara, Filla Alessandro, Coppola Giovanni, Rinaldi Carlo, Carbone Rosa, Pinto Stefano, Wang Qing, de Leva Maria Fulvia, Salvatore Elena, Banfi Sandro, Brunetti Arturo, Quarantelli Mario, Geschwind Daniel H, Pappatà Sabina, De Michele Giuseppe Two novel CYP7B1 mutations in Italian families with SPG5: a clinical
and genetic study..
Journal of neurology.
2009; 256(8):
1252-7.
Coppola Giovanni, Marmolino Daniele, Lu Daning, Wang Qing, Cnop Miriam, Rai Myriam, Acquaviva Fabio, Cocozza Sergio, Pandolfo Massimo, Geschwind Daniel H Functional genomic analysis of frataxin deficiency reveals
tissue-specific alterations and identifies the PPARgamma pathway as a
therapeutic target in Friedreich's ataxia..
Human molecular genetics.
2009; 18(13):
2452-61.
Bill Brent R, Geschwind Daniel H Genetic advances in autism: heterogeneity and convergence on shared
pathways..
Current opinion in genetics & development.
2009; 19(3):
271-8.
Bucan Maja, Abrahams Brett S, Wang Kai, Glessner Joseph T, Herman Edward I, Sonnenblick Lisa I, Alvarez Retuerto Ana I, Imielinski Marcin, Hadley Dexter, Bradfield Jonathan P, Kim Cecilia, Gidaya Nicole B, Lindquist Ingrid, Hutman Ted, Sigman Marian, Kustanovich Vlad, Lajonchere Clara M, Singleton Andrew, Kim Junhyong, Wassink Thomas H, McMahon William M, Owley Thomas, Sweeney John A, Coon Hilary, Nurnberger John I, Li Mingyao, Cantor Rita M, Minshew Nancy J, Sutcliffe James S, Cook Edwin H, Dawson Geraldine, Buxbaum Joseph D, Grant Struan F A, Schellenberg Gerard D, Geschwind Daniel H, Hakonarson Hakon Genome-wide analyses of exonic copy number variants in a family-based
study point to novel autism susceptibility genes..
PLoS genetics.
2009; 5(6):
e1000536.
Zai Laila, Ferrari Christina, Subbaiah Sathish, Havton Leif A, Coppola Giovanni, Strittmatter Stephen, Irwin Nina, Geschwind Daniel, Benowitz Larry I Inosine alters gene expression and axonal projections in neurons
contralateral to a cortical infarct and improves skilled use of the
impaired limb..
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2009; 29(25):
8187-97.
Wang Kai, Zhang Haitao, Ma Deqiong, Bucan Maja, Glessner Joseph T, Abrahams Brett S, Salyakina Daria, Imielinski Marcin, Bradfield Jonathan P, Sleiman Patrick M A, Kim Cecilia E, Hou Cuiping, Frackelton Edward, Chiavacci Rosetta, Takahashi Nagahide, Sakurai Takeshi, Rappaport Eric, Lajonchere Clara M, Munson Jeffrey, Estes Annette, Korvatska Olena, Piven Joseph, Sonnenblick Lisa I, Alvarez Retuerto Ana I, Herman Edward I, Dong Hongmei, Hutman Ted, Sigman Marian, Ozonoff Sally, Klin Ami, Owley Thomas, Sweeney John A, Brune Camille W, Cantor Rita M, Bernier Raphael, Gilbert John R, Cuccaro Michael L, McMahon William M, Miller Judith, State Matthew W, Wassink Thomas H, Coon Hilary, Levy Susan E, Schultz Robert T, Nurnberger John I, Haines Jonathan L, Sutcliffe James S, Cook Edwin H, Minshew Nancy J, Buxbaum Joseph D, Dawson Geraldine, Grant Struan F A, Geschwind Daniel H, Pericak-Vance Margaret A, Schellenberg Gerard D, Hakonarson Hakon Common genetic variants on 5p14.1 associate with autism spectrum
disorders..
Nature.
2009; 459(7246):
528-33.
Wexler Eric M, Paucer Andres, Kornblum Harley I, Palmer Theodore D, Plamer Theodore D, Geschwind Daniel H Endogenous Wnt signaling maintains neural progenitor cell potency..
Stem cells (Dayton, Ohio).
2009; 27(5):
1130-41.
Johnson Matthew B, Kawasawa Yuka Imamura, Mason Christopher E, Krsnik Zeljka, Coppola Giovanni, Bogdanović Darko, Geschwind Daniel H, Mane Shrikant M, State Matthew W, Sestan Nenad Functional and evolutionary insights into human brain development
through global transcriptome analysis..
Neuron.
2009; 62(4):
494-509.
Marques Fernanda, Sousa João C, Coppola Giovanni, Falcao Ana M, Rodrigues Ana João, Geschwind Daniel H, Sousa Nuno, Correia-Neves Margarida, Palha Joana A Kinetic profile of the transcriptome changes induced in the choroid
plexus by peripheral inflammation..
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2009; 29(5):
921-32.
Marques Fernanda, Sousa João C, Coppola Giovanni, Geschwind Daniel H, Sousa Nuno, Palha Joana A, Correia-Neves Margarida The choroid plexus response to a repeated peripheral inflammatory
stimulus..
BMC neuroscience.
2009; 10(1):
135.
Geschwind Daniel H Advances in autism..
Annual review of medicine.
2009; 60(3):
367-80.
Nagahara Alan H, Merrill David A, Coppola Giovanni, Tsukada Shingo, Schroeder Brock E, Shaked Gideon M, Wang Ling, Blesch Armin, Kim Albert, Conner James M, Rockenstein Edward, Chao Moses V, Koo Edward H, Geschwind Daniel, Masliah Eliezer, Chiba Andrea A, Tuszynski Mark H Neuroprotective effects of brain-derived neurotrophic factor in rodent
and primate models of Alzheimer's disease..
Nature medicine.
2009; 15(3):
331-7.
Winden Kellen D, Oldham Michael C, Mirnics Karoly, Ebert Philip J, Swan Christo H, Levitt Pat, Rubenstein John L, Horvath Steve, Geschwind Daniel H The organization of the transcriptional network in specific neuronal
classes..
Molecular systems biology.
2009; 5(3):
291.
Kumar Ravinesh A, Marshall Christian R, Badner Judith A, Babatz Timothy D, Mukamel Zohar, Aldinger Kimberly A, Sudi Jyotsna, Brune Camille W, Goh Gerald, Karamohamed Samer, Sutcliffe James S, Cook Edwin H, Geschwind Daniel H, Dobyns William B, Scherer Stephen W, Christian Susan L Association and mutation analyses of 16p11.2 autism candidate genes..
PloS one.
2009; 4(2):
e4582.
Kelly Theresa K, Karsten Stanislav L, Geschwind Daniel H, Kornblum Harley I Cell lineage and regional identity of cultured spinal cord neural stem
cells and comparison to brain-derived neural stem cells..
PloS one.
2009; 4(1):
e4213.
Wiedau-Pazos Martina, Wong Eugene, Solomon Esther, Alarcon Maricela, Geschwind Daniel H Wnt-pathway activation during the early stage of neurodegeneration in
FTDP-17 mice..
Neurobiology of aging.
2009; 30(1):
14-21.
Alvarez Retuerto Ana I, Cantor Rita M, Gleeson Joseph G, Ustaszewska Anna, Schackwitz Wendy S, Pennacchio Len A, Geschwind Daniel H Association of common variants in the Joubert syndrome gene (AHI1)
with autism..
Human molecular genetics.
2008; 17(24):
3887-96.
Ratan Rajiv R, Siddiq Ambreena, Aminova Leila, Langley Brett, McConoughey Stephen, Karpisheva Ksenia, Lee Hsin-Hwa, Carmichael Thomas, Kornblum Harley, Coppola Giovanni, Geschwind Daniel H, Hoke Ahmet, Smirnova Natalya, Rink Cameron, Roy Sashwati, Sen Chandan, Beattie Michael S, Hart Ron P, Grumet Martin, Sun Dongming, Freeman Robert S, Semenza Gregg L, Gazaryan Irina Small molecule activation of adaptive gene expression: tilorone or its
analogs are novel potent activators of hypoxia inducible factor-1 that
provide prophylaxis against stroke and spinal cord injury..
Annals of the New York Academy of Sciences.
2008; 1147(24):
383-94.
Vernes Sonja C, Newbury Dianne F, Abrahams Brett S, Winchester Laura, Nicod Jérôme, Groszer Matthias, Alarcón Maricela, Oliver Peter L, Davies Kay E, Geschwind Daniel H, Monaco Anthony P, Fisher Simon E A functional genetic link between distinct developmental language
disorders..
The New England journal of medicine.
2008; 359(22):
2337-45.
Oldham Michael C, Konopka Genevieve, Iwamoto Kazuya, Langfelder Peter, Kato Tadafumi, Horvath Steve, Geschwind Daniel H Functional organization of the transcriptome in human brain..
Nature neuroscience.
2008; 11(11):
1271-82.
Carmichael S Thomas, Vespa Paul M, Saver Jeffery L, Coppola Giovanni, Geschwind Daniel H, Starkman Sidney, Miller Chad M, Kidwell Chelsea S, Liebeskind David S, Martin Neil A Genomic profiles of damage and protection in human intracerebral
hemorrhage..
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2008; 28(11):
1860-75.
Schaffer Barbara A J, Bertram Lars, Miller Bruce L, Mullin Kristina, Weintraub Sandra, Johnson Nancy, Bigio Eileen H, Mesulam Marsel, Wiedau-Pazos Martina, Jackson George R, Cummings Jeffrey L, Cantor Rita M, Levey Allan I, Tanzi Rudolph E, Geschwind Daniel H Association of GSK3B with Alzheimer disease and frontotemporal
dementia..
Archives of neurology.
2008; 65(10):
1368-74.
Geschwind Daniel H Autism: many genes, common pathways?.
Cell.
2008; 135(3):
391-5.
Miller Julie E, Spiteri Elizabeth, Condro Michael C, Dosumu-Johnson Ryan T, Geschwind Daniel H, White Stephanie A Birdsong decreases protein levels of FoxP2, a molecule required for
human speech..
Journal of neurophysiology.
2008; 100(4):
2015-25.
Varki Ajit, Geschwind Daniel H, Eichler Evan E Explaining human uniqueness: genome interactions with environment,
behaviour and culture..
Nature reviews. Genetics.
2008; 9(10):
749-63.
Karsten Stanislav L, Kudo Lili C, Geschwind Daniel H Gene expression analysis of neural cells and tissues using DNA
microarrays..
Current protocols in neuroscience / editorial board, Jacqueline N. Crawley ... [et al.].
2008; Chapter 4(10):
Unit 4.28.
Rutherford Nicola J, Zhang Yong-Jie, Baker Matt, Gass Jennifer M, Finch Nicole A, Xu Ya-Fei, Stewart Heather, Kelley Brendan J, Kuntz Karen, Crook Richard J P, Sreedharan Jemeen, Vance Caroline, Sorenson Eric, Lippa Carol, Bigio Eileen H, Geschwind Daniel H, Knopman David S, Mitsumoto Hiroshi, Petersen Ronald C, Cashman Neil R, Hutton Mike, Shaw Christopher E, Boylan Kevin B, Boeve Bradley, Graff-Radford Neill R, Wszolek Zbigniew K, Caselli Richard J, Dickson Dennis W, Mackenzie Ian R, Petrucelli Leonard, Rademakers Rosa Novel mutations in TARDBP (TDP-43) in patients with familial
amyotrophic lateral sclerosis..
PLoS genetics.
2008; 4(9):
e1000193.
Thomas Elizabeth A, Coppola Giovanni, Desplats Paula A, Tang Bin, Soragni Elisabetta, Burnett Ryan, Gao Fuying, Fitzgerald Kelsey M, Borok Jenna F, Herman David, Geschwind Daniel H, Gottesfeld Joel M The HDAC inhibitor 4b ameliorates the disease phenotype and
transcriptional abnormalities in Huntington's disease transgenic mice..
Proceedings of the National Academy of Sciences of the United States of America.
2008; 105(40):
15564-9.
Geschwind Daniel H Autism: Family connections..
Nature.
2008; 454(7206):
838-9.
Coppola Giovanni, Karydas Anna, Rademakers Rosa, Wang Qing, Baker Matt, Hutton Mike, Miller Bruce L, Geschwind Daniel H Gene expression study on peripheral blood identifies progranulin
mutations..
Annals of neurology.
2008; 64(1):
92-6.
Abu-Elneel Kawther, Liu Tsunglin, Gazzaniga Francesca S, Nishimura Yuhei, Wall Dennis P, Geschwind Daniel H, Lao Kaiqin, Kosik Kenneth S Heterogeneous dysregulation of microRNAs across the autism spectrum..
Neurogenetics.
2008; 9(3):
153-61.
Rosen Rebecca F, Farberg Aaron S, Gearing Marla, Dooyema Jeromy, Long Patrick M, Anderson Daniel C, Davis-Turak Jeremy, Coppola Giovanni, Geschwind Daniel H, Paré Jean-Francois, Duong Timothy Q, Hopkins William D, Preuss Todd M, Walker Lary C Tauopathy with paired helical filaments in an aged chimpanzee..
The Journal of comparative neurology.
2008; 509(3):
259-70.
Dibbens Leanne M, Tarpey Patrick S, Hynes Kim, Bayly Marta A, Scheffer Ingrid E, Smith Raffaella, Bomar Jamee, Sutton Edwina, Vandeleur Lucianne, Shoubridge Cheryl, Edkins Sarah, Turner Samantha J, Stevens Claire, O'Meara Sarah, Tofts Calli, Barthorpe Syd, Buck Gemma, Cole Jennifer, Halliday Kelly, Jones David, Lee Rebecca, Madison Mark, Mironenko Tatiana, Varian Jennifer, West Sofie, Widaa Sara, Wray Paul, Teague John, Dicks Ed, Butler Adam, Menzies Andrew, Jenkinson Andrew, Shepherd Rebecca, Gusella James F, Afawi Zaid, Mazarib Aziz, Neufeld Miriam Y, Kivity Sara, Lev Dorit, Lerman-Sagie Tally, Korczyn Amos D, Derry Christopher P, Sutherland Grant R, Friend Kathryn, Shaw Marie, Corbett Mark, Kim Hyung-Goo, Geschwind Daniel H, Thomas Paul, Haan Eric, Ryan Stephen, McKee Shane, Berkovic Samuel F, Futreal P Andrew, Stratton Michael R, Mulley John C, Gécz Jozef X-linked protocadherin 19 mutations cause female-limited epilepsy and
cognitive impairment..
Nature genetics.
2008; 40(6):
776-81.
Lange Philipp S, Chavez Juan C, Pinto John T, Coppola Giovanni, Sun Chiao-Wang, Townes Tim M, Geschwind Daniel H, Ratan Rajiv R ATF4 is an oxidative stress-inducible, prodeath transcription factor
in neurons in vitro and in vivo..
The Journal of experimental medicine.
2008; 205(5):
1227-42.
Abrahams Brett S, Geschwind Daniel H Advances in autism genetics: on the threshold of a new neurobiology..
Nature reviews. Genetics.
2008; 9(5):
341-55.
Rai Myriam, Soragni Elisabetta, Jenssen Kai, Burnett Ryan, Herman David, Coppola Giovanni, Geschwind Daniel H, Gottesfeld Joel M, Pandolfo Massimo HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia
mouse model..
PloS one.
2008; 3(4):
e1958.
Krystal John H, Carter Cameron S, Geschwind Daniel, Manji Husseini K, March John S, Nestler Eric J, Zubieta Jon-Kar, Charney Dennis S, Goldman David, Gur Raquel E, Lieberman Jeffrey A, Roy-Byrne Peter, Rubinow David R, Anderson Stewart A, Barondes Samuel, Berman Karen F, Blair James, Braff David L, Brown E Sherwood, Calabrese Joseph R, Carlezon William A, Cook Edwin H, Davidson Richard J, Davis Michael, Desimone Robert, Drevets Wayne C, Duman Ronald S, Essock Susan M, Faraone Stephen V, Freedman Robert, Friston Karl J, Gelernter Joel, Geller Barbara, Gill Michael, Gould Elizabeth, Grace Anthony A, Grillon Christian, Gueorguieva Ralitza, Hariri Ahmad R, Innis Robert B, Jones Edward G, Kleinman Joel E, Koob George F, Krystal Andrew D, Leibenluft Ellen, Levinson Douglas F, Levitt Pat R, Lewis David A, Liberzon Israel, Lipska Barbara K, Marder Stephen R, Markou Athina, Mason Graeme F, McDougle Christopher J, McEwen Bruce S, McMahon Francis J, Meaney Michael J, Meltzer Herbert Y, Merikangas Kathleen R, Meyer-Lindenberg Andreas, Mirnics Károly, Monteggia Lisa M, Neumeister Alexander, O'Brien Charles P, Owen Michael J, Pine Daniel S, Rapoport Judith L, Rauch Scott L, Robbins Trevor W, Rosenbaum Jerrold F, Rosenberg David R, Ross Christopher A, Rush A John, Sackeim Harold A, Sanacora Gerard, Schatzberg Alan F, Shaham Yavin, Siever Larry J, Sunderland Trey, Tecott Laurence H, Thase Michael E, Todd Richard D, Weissman Myrna M, Yehuda Rachel, Yoshikawa Takeo, Young Elizabeth A, McCandless R It is time to take a stand for medical research and against terrorism
targeting medical scientists..
Biological psychiatry.
2008; 63(8):
725-7.
Cantor Rita M, Geschwind Daniel H Schizophrenia: genome, interrupted..
Neuron.
2008; 58(2):
165-7.
Marques Fernanda, Rodrigues Ana-João, Sousa João C, Coppola Giovanni, Geschwind Daniel H, Sousa Nuno, Correia-Neves Margarida, Palha Joana A Lipocalin 2 is a choroid plexus acute-phase protein..
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2008; 28(3):
450-5.
Miller Jeremy A, Oldham Michael C, Geschwind Daniel H A systems level analysis of transcriptional changes in Alzheimer's
disease and normal aging..
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2008; 28(6):
1410-20.
Alarcón Maricela, Abrahams Brett S, Stone Jennifer L, Duvall Jacqueline A, Perederiy Julia V, Bomar Jamee M, Sebat Jonathan, Wigler Michael, Martin Christa L, Ledbetter David H, Nelson Stanley F, Cantor Rita M, Geschwind Daniel H Linkage, association, and gene-expression analyses identify CNTNAP2 as
an autism-susceptibility gene..
American journal of human genetics.
2008; 82(1):
150-9.
Nakano Ichiro, Masterman-Smith Michael, Saigusa Kuniyasu, Paucar Andres A, Horvath Steve, Shoemaker Lorelei, Watanabe Momoko, Negro Alejandra, Bajpai Ruchi, Howes Amy, Lelievre Vincent, Waschek James A, Lazareff Jorge A, Freije William A, Liau Linda M, Gilbertson Richard J, Cloughesy Timothy F, Geschwind Daniel H, Nelson Stanley F, Mischel Paul S, Terskikh Alexey V, Kornblum Harley I Maternal embryonic leucine zipper kinase is a key regulator of the
proliferation of malignant brain tumors, including brain tumor stem
cells..
Journal of neuroscience research.
2008; 86(1):
48-60.
Bakkaloglu Betul, O'Roak Brian J, Louvi Angeliki, Gupta Abha R, Abelson Jesse F, Morgan Thomas M, Chawarska Katarzyna, Klin Ami, Ercan-Sencicek A Gulhan, Stillman Althea A, Tanriover Gamze, Abrahams Brett S, Duvall Jackie A, Robbins Elissa M, Geschwind Daniel H, Biederer Thomas, Gunel Murat, Lifton Richard P, State Matthew W Molecular cytogenetic analysis and resequencing of contactin
associated protein-like 2 in autism spectrum disorders..
American journal of human genetics.
2008; 82(1):
165-73.
Bartzokis George, Lu Po H, Geschwind Daniel H, Tingus Kathleen, Huang Danny, Mendez Mario F, Edwards Nancy, Mintz Jim Apolipoprotein E affects both myelin breakdown and cognition:
implications for age-related trajectories of decline into dementia..
Biological psychiatry.
2007; 62(12):
1380-7.
Vernes Sonja C, Spiteri Elizabeth, Nicod Jérôme, Groszer Matthias, Taylor Jennifer M, Davies Kay E, Geschwind Daniel H, Fisher Simon E High-throughput analysis of promoter occupancy reveals direct neural
targets of FOXP2, a gene mutated in speech and language disorders..
American journal of human genetics.
2007; 81(6):
1232-50.
Spiteri Elizabeth, Konopka Genevieve, Coppola Giovanni, Bomar Jamee, Oldham Michael, Ou Jing, Vernes Sonja C, Fisher Simon E, Ren Bing, Geschwind Daniel H Identification of the transcriptional targets of FOXP2, a gene linked
to speech and language, in developing human brain..
American journal of human genetics.
2007; 81(6):
1144-57.
Wexler Eric M, Geschwind Daniel H Out FOXing Parkinson disease: where development meets
neurodegeneration..
PLoS biology.
2007; 5(12):
e334.
Geschwind Daniel Autism: searching for coherence..
Biological psychiatry.
2007; 62(9):
949-50.
Martin Christa Lese, Duvall Jacqueline A, Ilkin Yesim, Simon Jason S, Arreaza M Gladys, Wilkes Kristin, Alvarez-Retuerto Ana, Whichello Amy, Powell Cynthia M, Rao Kathleen, Cook Edwin, Geschwind Daniel H Cytogenetic and molecular characterization of A2BP1/FOX1 as a
candidate gene for autism..
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics.
2007; 144B(7):
869-76.
Kudo Lili C, Karsten Stanislav L, Chen Ju, Levitt Pat, Geschwind Daniel H Genetic analysis of anterior posterior expression gradients in the
developing mammalian forebrain..
Cerebral cortex (New York, N.Y. : 1991).
2007; 17(9):
2108-22.
Nakano Ichiro, Dougherty Joseph D, Kim Kevin, Klement Ivan, Geschwind Daniel H, Kornblum Harley I Phosphoserine phosphatase is expressed in the neural stem cell niche
and regulates neural stem and progenitor cell proliferation..
Stem cells (Dayton, Ohio).
2007; 25(8):
1975-84.
Zhao Xiaoyue, Leotta Anthony, Kustanovich Vlad, Lajonchere Clara, Geschwind Daniel H, Law Kiely, Law Paul, Qiu Shanping, Lord Catherine, Sebat Jonathan, Ye Kenny, Wigler Michael A unified genetic theory for sporadic and inherited autism..
Proceedings of the National Academy of Sciences of the United States of America.
2007; 104(31):
12831-6.
Ringman John M, O'Neill Joseph, Geschwind Daniel, Medina Luis, Apostolova Liana G, Rodriguez Yaneth, Schaffer Barbara, Varpetian Arousiak, Tseng Benjamin, Ortiz Freddy, Fitten Jaime, Cummings Jeffrey L, Bartzokis George Diffusion tensor imaging in preclinical and presymptomatic carriers of
familial Alzheimer's disease mutations..
Brain : a journal of neurology.
2007; 130(Pt 7):
1767-76.
Nishimura Yuhei, Martin Christa L, Vazquez-Lopez Araceli, Spence Sarah J, Alvarez-Retuerto Ana Isabel, Sigman Marian, Steindler Corinna, Pellegrini Sandra, Schanen N Carolyn, Warren Stephen T, Geschwind Daniel H Genome-wide expression profiling of lymphoblastoid cell lines
distinguishes different forms of autism and reveals shared pathways..
Human molecular genetics.
2007; 16(14):
1682-98.
Duvall Jacqueline A, Lu Ake, Cantor Rita M, Todd Richard D, Constantino John N, Geschwind Daniel H A quantitative trait locus analysis of social responsiveness in
multiplex autism families..
The American journal of psychiatry.
2007; 164(4):
656-62.
Rodrigues Ana-João, Coppola Giovanni, Santos Cláudia, Costa Maria do Carmo, Ailion Michael, Sequeiros Jorge, Geschwind Daniel H, Maciel Patrícia Functional genomics and biochemical characterization of the C. elegans
orthologue of the Machado-Joseph disease protein ataxin-3..
The FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2007; 21(4):
1126-36.
Sebat Jonathan, Lakshmi B, Malhotra Dheeraj, Troge Jennifer, Lese-Martin Christa, Walsh Tom, Yamrom Boris, Yoon Seungtai, Krasnitz Alex, Kendall Jude, Leotta Anthony, Pai Deepa, Zhang Ray, Lee Yoon-Ha, Hicks James, Spence Sarah J, Lee Annette T, Puura Kaija, Lehtimäki Terho, Ledbetter David, Gregersen Peter K, Bregman Joel, Sutcliffe James S, Jobanputra Vaidehi, Chung Wendy, Warburton Dorothy, King Mary-Claire, Skuse David, Geschwind Daniel H, Gilliam T Conrad, Ye Kenny, Wigler Michael Strong association of de novo copy number mutations with autism..
Science (New York, N.Y.).
2007; 316(5823):
445-9.
Stone Jennifer L, Merriman Barry, Cantor Rita M, Geschwind Daniel H, Nelson Stanley F High density SNP association study of a major autism linkage region on
chromosome 17..
Human molecular genetics.
2007; 16(6):
704-15.
Nelson Stanley F, Szatmari Peter, Paterson Andrew D, Zwaigenbaum Lonnie, Roberts Wendy, Brian Jessica, Liu Xiao-Qing, Vincent John B, Skaug Jennifer L, Thompson Ann P, Senman Lili, Feuk Lars, Qian Cheng, Bryson Susan E, Jones Marshall B, Marshall Christian R, Scherer Stephen W, Vieland Veronica J, Bartlett Christopher, Mangin La Vonne, Goedken Rhinda, Segre Alberto, Pericak-Vance Margaret A, Cuccaro Michael L, Gilbert John R, Wright Harry H, Abramson Ruth K, Betancur Catalina, Bourgeron Thomas, Gillberg Christopher, Leboyer Marion, Buxbaum Joseph D, Davis Kenneth L, Hollander Eric, Silverman Jeremy M, Hallmayer Joachim, Lotspeich Linda, Sutcliffe James S, Haines Jonathan L, Folstein Susan E, Piven Joseph, Wassink Thomas H, Sheffield Val, Geschwind Daniel H, Bucan Maja, Brown W Ted, Cantor Rita M, Constantino John N, Gilliam T Conrad, Herbert Martha, Lajonchere Clara, Ledbetter David H, Lese-Martin Christa, Miller Janet, Nelson Stan, Samango-Sprouse Carol A, Spence Sarah, State Matthew, Tanzi Rudolph E, Coon Hilary, Dawson Geraldine, Devlin Bernie, Estes Annette, Flodman Pamela, Klei Lambertus, McMahon William M, Minshew Nancy, Munson Jeff, Korvatska Elena, Rodier Patricia M, Schellenberg Gerard D, Smith Moyra, Spence M Anne, Stodgell Chris, Tepper Ping Guo, Wijsman Ellen M, Yu Chang-En, Rogé Bernadette, Mantoulan Carine, Wittemeyer Kerstin, Poustka Annemarie, Felder Bärbel, Klauck Sabine M, Schuster Claudia, Poustka Fritz, Bölte Sven, Feineis-Matthews Sabine, Herbrecht Evelyn, Schmötzer Gabi, Tsiantis John, Papanikolaou Katerina, Maestrini Elena, Bacchelli Elena, Blasi Francesca, Carone Simona, Toma Claudio, Van Engeland Herman, de Jonge Maretha, Kemner Chantal, Koop Frederieke, Koop Frederike, Langemeijer Marjolein, Langemeijer Marjolijn, Hijmans Channa, Hijimans Channa, Staal Wouter G, Baird Gillian, Bolton Patrick F, Rutter Michael L, Weisblatt Emma, Green Jonathan, Aldred Catherine, Wilkinson Julie-Anne, Pickles Andrew, Le Couteur Ann, Berney Tom, McConachie Helen, Bailey Anthony J, Francis Kostas, Honeyman Gemma, Hutchinson Aislinn, Parr Jeremy R, Wallace Simon, Monaco Anthony P, Barnby Gabrielle, Kobayashi Kazuhiro, Lamb Janine A, Sousa Ines, Sykes Nuala, Cook Edwin H, Guter Stephen J, Leventhal Bennett L, Salt Jeff, Lord Catherine, Corsello Christina, Hus Vanessa, Weeks Daniel E, Volkmar Fred, Tauber Maïté, Fombonne Eric, Shih Andy, Meyer Kacie J Mapping autism risk loci using genetic linkage and chromosomal
rearrangements..
Nature genetics.
2007; 39(3):
319-28.
Geschwind Daniel H, Levitt Pat Autism spectrum disorders: developmental disconnection syndromes..
Current opinion in neurobiology.
2007; 17(1):
103-11.
Sengupta Soma, Horowitz Peleg M, Karsten Stanislav L, Jackson George R, Geschwind Daniel H, Fu Yifan, Berry Robert W, Binder Lester I Degradation of tau protein by puromycin-sensitive aminopeptidase in
vitro..
Biochemistry.
2006; 45(50):
15111-9.
Poon Michael M, Choi Sang-Hyun, Jamieson Christina A M, Geschwind Daniel H, Martin Kelsey C Identification of process-localized mRNAs from cultured rodent
hippocampal neurons..
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2006; 26(51):
13390-9.
Oldham Michael C, Horvath Steve, Geschwind Daniel H Conservation and evolution of gene coexpression networks in human and
chimpanzee brains..
Proceedings of the National Academy of Sciences of the United States of America.
2006; 103(47):
17973-8.
White Stephanie A, Fisher Simon E, Geschwind Daniel H, Scharff Constance, Holy Timothy E Singing mice, songbirds, and more: models for FOXP2 function and
dysfunction in human speech and language..
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2006; 26(41):
10376-9.
Karsten Stanislav L, Sang Tzu-Kang, Gehman Lauren T, Chatterjee Shreyasi, Liu Jiankai, Lawless George M, Sengupta Soma, Berry Robert W, Pomakian Justine, Oh Hyun S, Schulz Cordula, Hui Koon-Sea, Wiedau-Pazos Martina, Vinters Harry V, Binder Lester I, Geschwind Daniel H, Jackson George R A genomic screen for modifiers of tauopathy identifies
puromycin-sensitive aminopeptidase as an inhibitor of tau-induced
neurodegeneration..
Neuron.
2006; 51(5):
549-60.
Spence, S. J. Cantor, R. M. Chung, L. Kim, S. Geschwind, D. H. Alarcon, M. Stratification based on language-related endophenotypes in autism: Attempt to replicate reported linkage.
Am J Med Genet B Neuropsychiatr Genet.
2006;
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Groszer, M. Erickson, R. Scripture-Adams, D. D. Dougherty, J. D. Le Belle, J. Zack, J. A. Geschwind, D. H. Liu, X. Kornblum, H. I. Wu, H. PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry.
Proc Natl Acad Sci U S A.
2006; 103(1):
111-6.
Dougherty, J. D. Garcia, A. D. Nakano, I. Livingstone, M. Norris, B. Polakiewicz, R. Wexler, E. M. Sofroniew, M. V. Kornblum, H. I. Geschwind, D. H. PBK/TOPK, a proliferating neural progenitor-specific mitogen-activated protein kinase kinase.
J Neurosci.
2005; 25(46):
10773-85.
Nakano, I. Paucar, A. A. Bajpai, R. Dougherty, J. D. Zewail, A. Kelly, T. K. Kim, K. J. Ou, J. Groszer, M. Imura, T. Freije, W. A. Nelson, S. F. Sofroniew, M. V. Wu, H. Liu, X. Terskikh, A. V. Geschwind, D. H. Kornblum, H. I. Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation.
J Cell Biol.
2005; 170(3):
413-27.
Sun, T. Patoine, C. Abu-Khalil, A. Visvader, J. Sum, E. Cherry, T. J. Orkin, S. H. Geschwind, D. H. Walsh, C. A. Early asymmetry of gene transcription in embryonic human left and right cerebral cortex.
Science.
2005; 308(5729):
1794-8.
Karsten, S. L. Geschwind, D. H. Exercise your amyloid.
Cell.
2005; 120(5):
572-4.
Dougherty, J. D. Geschwind, D. H. Progress in realizing the promise of microarrays in systems neurobiology.
Neuron.
2005; 45(2):
183-5.
Oliveira, J. R. Spiteri, E. Sobrido, M. J. Hopfer, S. Klepper, J. Voit, T. Gilbert, J. Wszolek, Z. K. Calne, D. B. Stoessl, A. J. Hutton, M. Manyam, B. V. Boller, F. Baquero, M. Geschwind, D. H. Genetic heterogeneity in familial idiopathic basal ganglia calcification (Fahr disease).
Neurology.
2004; 63(11):
2165-7.
Abu-Khalil, A. Fu, L. Grove, E. A. Zecevic, N. Geschwind, D. H. Wnt genes define distinct boundaries in the developing human brain: implications for human forebrain patterning.
J Comp Neurol.
2004; 474(2):
276-88.
Jen, J. C. Chan, W. M. Bosley, T. M. Wan, J. Carr, J. R. Rub, U. Shattuck, D. Salamon, G. Kudo, L. C. Ou, J. Lin, D. D. Salih, M. A. Kansu, T. Al Dhalaan, H. Al Zayed, Z. MacDonald, D. B. Stigsby, B. Plaitakis, A. Dretakis, E. K. Gottlob, I. Pieh, C. Traboulsi, E. I. Wang, Q. Wang, L. Andrews, C. Yamada, K. Demer, J. L. Karim, S. Alger, J. R. Geschwind, D. H. Deller, T. Sicotte, N. L. Nelson, S. F. Baloh, R. W. Engle, E. C. Mutations in a human ROBO gene disrupt hindbrain axon pathway crossing and morphogenesis.
Science.
2004; 304(5676):
1509-13.
Teramitsu, I. Kudo, L. C. London, S. E. Geschwind, D. H. White, S. A. Parallel FoxP1 and FoxP2 expression in songbird and human brain predicts functional interaction.
J Neurosci.
2004; 24(13):
3152-63.
Bragin, A. Karsten, S. L. Almajano, J. Wilson, C. L. Geschwind, D. H. Engel, J., Jr. Large-scale microarray gene expression analysis in discrete electrophysiologically identified neuronal clusters.
J Neurosci Methods.
2004; 133(1-2):
49-55.
Hedlund, E. Karsten, S. L. Kudo, L. Geschwind, D. H. Carpenter, E. M. Identification of a Hoxd10-regulated transcriptional network and combinatorial interactions with Hoxa10 during spinal cord development.
J Neurosci Res.
2004; 75(3):
307-19.
Easterday, M. C. Dougherty, J. D. Jackson, R. L. Ou, J. Nakano, I. Paucar, A. A. Roobini, B. Dianati, M. Irvin, D. K. Weissman, I. L. Terskikh, A. V. Geschwind, D. H. Kornblum, H. I. Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations.
Dev Biol.
2003; 264(2):
309-22.
Hemmati, H. D. Nakano, I. Lazareff, J. A. Masterman-Smith, M. Geschwind, D. H. Bronner-Fraser, M. Kornblum, H. I. Cancerous stem cells can arise from pediatric brain tumors.
Proc Natl Acad Sci U S A.
2003; 100(25):
15178-83.
Geschwind, D. H. Tau phosphorylation, tangles, and neurodegeneration: the chicken or the egg?.
Neuron.
2003; 40(3):
457-60.
Caceres, M. Lachuer, J. Zapala, M. A. Redmond, J. C. Kudo, L. Geschwind, D. H. Lockhart, D. J. Preuss, T. M. Barlow, C. Elevated gene expression levels distinguish human from non-human primate brains.
Proc Natl Acad Sci U S A.
2003; 100(22):
13030-5.
Karsten, S. L. Kudo, L. C. Jackson, R. Sabatti, C. Kornblum, H. I. Geschwind, D. H. Global analysis of gene expression in neural progenitors reveals specific cell-cycle, signaling, and metabolic networks.
Dev Biol.
2003; 261(1):
165-82.
Compton, P. Geschwind, D. H. Alarcon, M. Association between human mu-opioid receptor gene polymorphism, pain tolerance, and opioid addiction.
Am J Med Genet B Neuropsychiatr Genet.
2003; 121(1):
76-82.
Fu, L. Abu-Khalil, A. Morrison, R. S. Geschwind, D. H. Kornblum, H. I. Expression patterns of epidermal growth factor receptor and fibroblast growth factor receptor 1 mRNA in fetal human brain.
J Comp Neurol.
2003; 462(2):
265-73.
Sobrido, M. J. Abu-Khalil, A. Weintraub, S. Johnson, N. Quinn, B. Cummings, J. L. Mesulam, M. M. Geschwind, D. H. Possible association of the tau H1/H1 genotype with primary progressive aphasia.
Neurology.
2003; 60(5):
862-4.
Schaffer, B. Wiedau-Pazos, M. Geschwind, D. H. Gene structure and alternative splicing of glycogen synthase kinase 3 beta (GSK-3beta) in neural and non-neural tissues.
Gene.
2003; 302(1-2):
73-81.
Jackson, GR Wiedau-Pazos, M Sang, TK Wagle, N Brown, CA Massachi, S Geschwind, DH Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila..
Neuron. .
2002; 34(4):
509-19.
Geschwind, D. H. Miller, B. L. DeCarli, C. Carmelli, D. Heritability of lobar brain volumes in twins supports genetic models of cerebral laterality and handedness.
Proc Natl Acad Sci U S A.
2002; 99(5):
3176-81.
Geschwind, DH Miller, BL DeCarli, C Carmelli, D Heritability of lobar brain volumes in twins supports genetic models of cerebral laterality and handedness..
Proceedings of the National Academy of Sciences of the United States of America. .
2002; 99(5):
3176-81.
Karsten, S. L. Van Deerlin, V. M. Sabatti, C. Gill, L. H. Geschwind, D. H. An evaluation of tyramide signal amplification and archived fixed and frozen tissue in microarray gene expression analysis.
Nucleic Acids Res.
2002; 30(2):
E4.
Sobrido, M. J. Cholfin, J. A. Perlman, S. Pulst, S. M. Geschwind, D. H. SCA8 repeat expansions in ataxia: a controversial association.
Neurology.
2001; 57(7):
1310-2.
Geschwind, D. H. Miller, B. L. Molecular approaches to cerebral laterality: development and neurodegeneration.
Am J Med Genet.
2001; 101(4):
370-81.
Terskikh, AV Easterday, MC Li, L Hood, L Kornblum, HI Geschwind, DH Weissman, IL From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs..
Proceedings of the National Academy of Sciences of the United States of America. .
2001; 98(14):
7934-9.
Geschwind, DH Sharing gene expression data: an array of options..
Nature reviews. Neuroscience. .
2001; 2(6):
435-8.
Luo, Z Geschwind, DH Microarray applications in neuroscience..
Neurobiology of disease. .
2001; 8(2):
183-93.
Geschwind, DH Mice, microarrays, and the genetic diversity of the brain..
Proceedings of the National Academy of Sciences of the United States of America. .
2000; 97(20):
10676-8.
Geschwind, D. H. Founders and CAG repeats: cause or effect?.
Neurology.
1999; 52(4):
685-6.
Hong, M. Zhukareva, V. Vogelsberg-Ragaglia, V. Wszolek, Z. Reed, L. Miller, B. I. Geschwind, D. H. Bird, T. D. McKeel, D. Goate, A. Morris, J. C. Wilhelmsen, K. C. Schellenberg, G. D. Trojanowski, J. Q. Lee, V. M. Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17.
Science.
1998; 282(5395):
1914-7.
Clark, L. N. Poorkaj, P. Wszolek, Z. Geschwind, D. H. Nasreddine, Z. S. Miller, B. Li, D. Payami, H. Awert, F. Markopoulou, K. Andreadis, A. D'Souza, I. Lee, V. M. Reed, L. Trojanowski, J. Q. Zhukareva, V. Bird, T. Schellenberg, G. Wilhelmsen, K. C. Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17.
Proc Natl Acad Sci U S A.
1998; 95(22):
13103-7.
Geschwind, D. H. Kelly, G. M. Fryer, H. Feeser-Bhatt, H. Hockfield, S. Identification and characterization of novel developmentally regulated proteins in rat spinal cord.
Brain Res Dev Brain Res.
1996; 97(1):
62-75.
