Christopher S. Colwell is a Neuroscientist who has served on the UCLA School of Medicine faculty since he joined the Department of Psychiatry and Biobehavioral Sciences in 1997. He became a Professor in 2008. Dr. Colwell earned his B.S. in Neuroscience from Vanderbilt University in 1985. During this time, he started his research in circadian rhythms under the mentorship of Dr. T. Page. Dr. Colwell earned his Ph.D. in Biology at the University of Virginia in 1991. His thesis work explored the neural mechanisms by which light regulates circadian rhythms. Dr. Colwell continued this line of research during a postdoctoral fellowship at the University of Virginia with Dr. G. Block. A second postdoctoral fellowship was carried out on the topics of motor control and excitotoxicity in the laboratory of Dr. M. Levine at UCLA. Dr. Colwell learned how to utilize imaging techniques to measure calcium levels inside neurons while a visiting scientist in the laboratory of Dr. Konnerth at the University of Saarland, Germany. Since Dr. Colwell's faculty appointment at UCLA, his laboratory's research has focused on understanding the mechanisms underlying circadian rhythms in mammals. Dysfunction in the timing these daily cycles is a key symptom in a number of neurological and psychiatric disorders. Better understanding the basic biology of this timing system should result in new therapies to improve the quality of life of these patients and the people who care for them.
Contact information
Work Address:
Office
760 Westwood Plaza
Los Angeles, CA 90024
UNITED STATES
Work Address:
Laboratory
760 Westwood Plaza
Los Angeles, CA 90095
UNITED STATES
Research Interests
Neural Control of Behavior, Circadian Rhythms
The central goal of our research effort is to understand the molecular, cellular, and systems-level mechanisms that underlie the generation of circadian rhythms and their regulation by light. This work is carried out using rodents and the marine mollusk Aplysia california as model organisms. Our most recent work utilizes calcium imaging and electrophysiological techniques to study synaptic communication in the suprachiasmatic nucleus (SCN). This cellular/molecular analysis is combined with a systems-level analysis of the effects of genetic and pharmacological manipulations on circadian rhythms in behavior. This integration of cellular/molecular and systems-level analysis is central to the approach we take to address research questions. Our ongoing research is focused on 4 projects: Laboratory of Circadian Neurobiology Project I: Circadian Regulation of Calcium in SCN Neurons. Project II: Role of Neuropeptides in the circadian system. Project III: Coupling between cells in the SCN. Project IV: Circadian Regulation of Learned Behaviors. http://www.mrrc.npi.ucla.edu/ccolwell
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Publications
Mengatto Cristiane Machado, Mussano Federico, Honda Yoshitomo, Colwell Christopher S, Nishimura Ichiro Circadian rhythm and cartilage extracellular matrix genes in
osseointegration: a genome-wide screening of implant failure by
vitamin D deficiency..
PloS one.
2011; 6(1):
e15848.
Atkinson Susan E, Maywood Elizabeth S, Chesham Johanna E, Wozny Christian, Colwell Christopher S, Hastings Michael H, Williams Stephen R Cyclic AMP signaling control of action potential firing rate and
molecular circadian pacemaking in the suprachiasmatic nucleus..
Journal of biological rhythms.
2011; 26(3):
210-20.
Hu Wang-Ping, Li Jia-Da, Colwell Christopher S, Zhou Qun-Yong Decreased REM sleep and altered circadian sleep regulation in mice
lacking vasoactive intestinal polypeptide..
Sleep.
2011; 34(1):
49-56.
Kudo Takashi, Schroeder Analyne, Loh Dawn H, Kuljis Dika, Jordan Maria C, Roos Kenneth P, Colwell Christopher S Dysfunctions in circadian behavior and physiology in mouse models of
Huntington's disease..
Experimental neurology.
2011; 228(1):
80-90.
Loh Dawn H, Dragich Joanna M, Kudo Takashi, Schroeder Analyne M, Nakamura Takahiro J, Waschek James A, Block Gene D, Colwell Christopher S Effects of vasoactive intestinal peptide genotype on circadian gene
expression in the suprachiasmatic nucleus and peripheral organs..
Journal of biological rhythms.
2011; 26(3):
200-9.
Gamble Karen L, Kudo Takashi, Colwell Christopher S, McMahon Douglas G Gastrin-releasing peptide modulates fast delayed rectifier potassium
current in Per1-expressing SCN neurons..
Journal of biological rhythms.
2011; 26(2):
99-106.
Colwell Christopher S Neuroscience: Sleepy neurons?.
Nature.
2011; 472(7344):
427-8.
Itri JN, Vosko AM, Schroeder A, Dragich JM, Michel S, and Colwell CS Circadian Regulation of A-type Potassium Currents in the Suprachiasmatic Nucleus..
J Neurophysiol
2010; 103:
632-640.
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Nakamura TJ, Sellix MT, Kudo T, Nakao N, Yoshimura T, Ebihara S, Colwell CS and Block GD Estrous Variations of Circadian Clock Gene Expression in Reproductive Tissues..
Steriods
2010; 75:
203-212.
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Christopher S. Colwell Preventing dehydration during sleep.
Nature Neuroscience
2010; 13(4):
1-2.
Loh Dawn H, Navarro Juliana, Hagopian Arkady, Wang Louisa M, Deboer Tom, Colwell Christopher S Rapid changes in the light/dark cycle disrupt memory of conditioned
fear in mice..
PloS one.
2010; 5(9):
.
Fulton Daniel, Paez Pablo M, Fisher Robin, Handley Vance, Colwell Christopher S, Campagnoni Anthony T Regulation of L-type Ca++ currents and process morphology in white
matter oligodendrocyte precursor cells by golli-myelin proteins..
Glia.
2010; 58(11):
1292-303.
Dragich JM, Loh DH, Wang LM, Vosko AM, Kudo T, Nakamura TJ, Odom IH, Tateyama S, Hagopian A, Waschek JA and Colwell CS The Role of the Neuropeptides PACAP and VIP in the Photic Regulation of Gene Expression in the Suprachiasmatic Nucleus. .
Eur. J. Neurosci.
2010; 31:
864-875.
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Dragich Joanna M, Loh Dawn H, Wang Louisa M, Vosko Andrew M, Kudo Takashi, Nakamura Takahiro J, Odom Irene H, Tateyama Sei, Hagopian Arkady, Waschek James A, Colwell Christopher S The role of the neuropeptides PACAP and VIP in the photic regulation
of gene expression in the suprachiasmatic nucleus..
The European journal of neuroscience.
2010; 31(5):
864-75.
Wang LMC, Dragich JM, Kudo T, Odom IH, Welsh DK, O?Dell TJ, Colwell CS Expression of the circadian clock gene Period2 in the hippocampus: Possible implications for synaptic plasticity and learned behavior..
ASN_Neuro
2009; 1(3):
139-152.
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Paez P, Fulton D, Spreuer V, Handley V, Campagnoni C, Macklin W, Colwell CS, and Campagnoni AT Golli myelin basic proteins regulate oligodendroglial progenitor cell migration through voltage-gated Ca2+ influx. .
J. Neuroscience
2009; 29(20):
6663-6676.
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Ciarleglio CM, Gamble KL, Axley JC, Strauss BR, Cohen JY, CS Colwell, and DG McMahon Population Encoding by Circadian Clock Neurons Organizes Circadian Behavior..
J. Neuroscience
2009; 29(6):
1670-1676.
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Choi HJ, Lee CJ, Schroeder A, Kim YS, Jung SH, JS Kim JS, Kim DY, Sohn EJ, Han HC, Hong SK, Colwell CS, Kim YI Excitatory Actions of GABA in the Suprachiasmatic Nucleus..
J. Neuroscience
2008; 28(21):
5450-9.
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Wang LM, Schroeder A, Loh D, Smith D, Lin K, Han JH, Michel S, Hummer DL, Ehlen JC, Albers HE, Colwell CS Role for the NR2B Subunit of the NMDA Receptor in Mediating Light Input to the Circadian System..
Eur. J. Neurosci.
2008; 27(7):
1771-9.
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Chaudhury D, Loh DH, Dragich J, Hagopian A, Colwell CS Select cognitive deficits in Vasoactive Intestinal Peptide deficient mice..
BMC_Neuroscience
2008; 9:
63.
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Loh DH, Abad C, Colwell CS, Waschek JA Vasoactive Intestinal Peptide is Critical for Circadian Regulation of Glucocorticoids..
Neuroendocrinology
2008; 88(4):
246-255.
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Paez P, Fulton D, Colwell CS, Campagnoni AT Voltage-operated Ca2+ and Na+ channels in the oligodendrocyte linage..
J. Neuroscience Res.
2008;
.
Brown T, Colwell CS, Waschek J, Piggins H Disrupted neuronal activity rhythms in the suprachiasmatic nuclei of vasoactive intestinal polypeptide-deficient mice..
J. Neurophysiol.
2007; 97 :
2553-2558.
C.S. Colwell Soporific signaling: how flies sleep through the night..
Nature Neuroscience
2007; 10(9):
1079-1080.
Vosko AM, Schroeder A, Loh DH, Colwell CS Vasoactive intestinal peptide and the mammalian circadian system..
Gen Comp Endocrinol.
2007; 152(2-3):
165-175.
Kim YI, Choi H-J, Colwell CS BDNF Regulation of NMDA Receptor-Mediated Synaptic Currents in Suprachiasmatic Nucleus Neurons..
J. Neurosci. Res.
2006; 84(7):
1512-20.
Michel S, Clark JP, Ding JM, Colwell CS BDNF and Neurotrophin Receptors Modulate Glutamate-Induced Phase Shifts of the Suprachiasmatic Nucleus..
Eur. J. Neuroscience.
2006; 24(4):
1109-16.
Colwell CS BK channels and circadian output..
Nature Neuroscience
2006; 9(8):
985-6.
Feng JM, Hu YK, Xie LH, Colwell CS, Shao XM, Sun XP, Chen B, Tang H, Campagnoni AT Golli protein negatively regulates store depletion-induced calcium influx in T cells..
Immunity
2006; 24(6):
717-727.
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Michel S, Itri J, Han JH, Gniotczynski K, Colwell CS Regulation of glutamatergic signalling by PACAP in the mammalian suprachiasmatic nucleus..
BMC_Neuroscience
2006; 7:
15.
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Colwell, CS Bridging the gap: coupling single-cell oscillators in the suprachiasmatic nucleus..
Nature neuroscience. .
2005; 8(1):
10-2.
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Itri, JN Michel, S Vansteensel, MJ Meijer, JH Colwell, CS Fast delayed rectifier potassium current is required for circadian neural activity..
Nature neuroscience. .
2005; 8(5):
650-6.
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Jacobs, EC Pribyl, TM Kampf, K Campagnoni, C Colwell, CS Reyes, SD Martin, M Handley, V Hiltner, TD Readhead, C Jacobs, RE Messing, A Fisher, RS Campagnoni, AT Region-specific myelin pathology in mice lacking the golli products of the myelin basic protein gene..
The Journal of neuroscience : the official journal of the Society for Neuroscience. .
2005; 25(30):
7004-13.
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Aton SJ, Colwell CS, Harmar AJ, Waschek J, and Herzog ED Vasoactive intestinal polypeptide mediates circadian rhythmicity and synchrony in distinct subsets of mammalian clock neurons..
Nature Neurosci.
2005; 8(4):
476-483.
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Itri, J Michel, S Waschek, JA Colwell, CS Circadian rhythm in inhibitory synaptic transmission in the mouse suprachiasmatic nucleus..
Journal of neurophysiology. .
2004; 92(1):
311-9.
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Colwell CS, Michel S, Itri J, Rodriguez W, Tam J, Lelievre V, Hu Z, Liu X and Waschek JA Disrupted Circadian Rhythms and Synaptic Communication in Vasoactive Intestinal Peptide-Deficient Mice..
Am. J. Physiol.
2003; 285(5):
R939-R949.
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Itri J, Colwell CS Presynaptic regulation of gamma-aminobutyric acid (GABA) release by vasoactive intestinal peptide (VIP) in the mouse suprachiasmatic nucleus.
J. Neurophysiol.
2003; 90(3):
1589-1597.
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Colwell, CS Michel, S Sleep and circadian rhythms: do sleep centers talk back to the clock?.
Nature neuroscience. .
2003; 6(10):
1005-6.
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Chaudhury D, Colwell CS Circadian Modulation of Learning and Memory in Fear-Conditioned Mice..
Behavioral Brain Research
2002; 133:
95-108.
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Michel, S Itri, J Colwell, CS Excitatory mechanisms in the suprachiasmatic nucleus: the role of AMPA/KA glutamate receptors..
Journal of neurophysiology. .
2002; 88(2):
817-28.
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Colwell, CS Levine, MS Metabotropic glutamate receptor modulation of excitotoxicity in the neostriatum: role of calcium channels..
Brain research. .
1999; 833(2):
234-41.
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Colwell CS. Circadian Rhythms..
Psychopharmacology: the fourth generation of progress. CD/ROM.
1998;
.
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Cepeda, C Colwell, CS Itri, JN Chandler, SH Levine, MS Dopaminergic modulation of NMDA-induced whole cell currents in neostriatal neurons in slices: contribution of calcium conductances..
Journal of neurophysiology. .
1998; 79(1):
82-94.
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Levine MS, Cepeda C, Colwell CS, Yu Q, Chandler SH Infrared video microscopy: visualization and manipulation of neurons in neostriatal slices..
Receptor Localization: Laboratory Methods and Procedures
1998;
.
Colwell CS, Cepeda C, Crawford C, Levine MS Postnatal Development of NMDA Evoked Responses in the Neostriatum..
J. Dev. Neurobiology
1998; 20:
154-163..
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Colwell, CS Circadian rhythms. Time to get excited by GABA..
Nature. .
1997; 387(6633):
554-5.
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Colwell CS, Levine MS Histamine modulates NMDA-dependent swelling in the developing neostriatum..
Brain Research
1997; 766:
205-212.
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Colwell, CS Levine, MS Glutamate receptor-induced toxicity in neostriatal cells..
Brain research. .
1996; 724(2):
205-12.
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Colwell, CS Altemus, KL Levine, MS Metabotropic glutamate receptor activation selectively limits excitotoxic damage in the intact neostriatum..
Brain research. .
1996; 726(1-2):
223-6.
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Colwell CS, Altemus KL, Cepeda C, Levine MS Regulation of NMDA-induced toxicity in the neostriatum: a new role for metabotropic glutamate receptors?.
Proc. Natl. Acad. Science
1996; 93(3):
1200-1204.
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Colwell CS Regulation of Photic Input to Circadian Systems: a role for serotonin..
Nervous systems and Behaviour.
1995;
131.
Colwell CS, Menaker M. Regulation of circadian rhythms by excitatory amino acids..
Excitatory amino acids: Their Role in Neuroendocrine Function.
1995;
223-252.
Colwell, CS Levine, MS Metabotropic glutamate receptors modulate N-methyl-D-aspartate receptor function in neostriatal neurons..
Neuroscience. .
1994; 61(3):
497-507.
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Rea MA, Glass JD, Colwell CS Serotonin modulates the photic response of the circadian oscillator in the hamster suprachiasmatic nucleus..
J. Neuroscience
1994; 14:
3635-3642.
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Colwell, CS Kaufman, CM Menaker, M Ralph, MR Light-induced phase shifts and Fos expression in the hamster circadian system: the effects of anesthetics..
Journal of biological rhythms. .
1993; 8(3):
179-88.
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Colwell CS, Kaufman CM, Menaker M Photic induction of Fos in the hamster suprachiasmatic nucleus is inhibited by baclofen but not by diazepam or bicucullin..
Neuroscience Lett.
1993; 163:
177-181.
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Foster, RG Argamaso, S Coleman, S Colwell, CS Lederman, A Provencio, I Photoreceptors regulating circadian behavior: a mouse model..
Journal of biological rhythms. .
1993; 8 Suppl:
S17-23.
Colwell CS, Khalsa SBS, Block GD Cellular mechanisms of entrainment..
Chronobiol. International
1992; 9:
163-179.
Colwell CS, Khalsa SBS, Block GD FMRFamide antagonizes the actions of 5-HT and light on a circadian rhythm recorded from the eye of Aplysia..
J. Comp. Physiology
1992; 170:
211-215.
Colwell, CS Menaker, M NMDA as well as non-NMDA receptor antagonists can prevent the phase-shifting effects of light on the circadian system of the golden hamster..
Journal of biological rhythms. .
1992; 7(2):
125-36.
Colwell, CS Max, M Hudson, D Menaker, M Excitatory amino acid receptors may mediate the effects of light on the reproductive system of the golden hamster..
Biology of reproduction. .
1991; 44(4):
604-8.
Colwell, CS Foster, RG Menaker, M NMDA receptor antagonists block the effects of light on circadian behavior in the mouse..
Brain research. .
1991; 554(1-2):
105-10.
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Colwell CS, Page TL Circadian rhythms in spontaneous neural activity recorded in vivo and in vitro from cockroach's central nervous system..
J. Comp. Physiology
1990; 166:
643-649.
Colwell CS, Ralph M, Menaker M Do NMDA receptors mediate the effects of light on circadian behavior in the golden hamster..
Brain Research
1990; 523:
117-120.
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Colwell CS Interactive effects of serotonin and light on the circadian rhythm of neural activity recorded from the eye of Aplysia..
J. Comp. Physiology
1990; 167:
841-845.
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